CA2683224A1 - System and methods thereof for treatment of ocular disorders - Google Patents

System and methods thereof for treatment of ocular disorders Download PDF

Info

Publication number
CA2683224A1
CA2683224A1 CA002683224A CA2683224A CA2683224A1 CA 2683224 A1 CA2683224 A1 CA 2683224A1 CA 002683224 A CA002683224 A CA 002683224A CA 2683224 A CA2683224 A CA 2683224A CA 2683224 A1 CA2683224 A1 CA 2683224A1
Authority
CA
Canada
Prior art keywords
stent
implant
eye
glaucoma
anterior chamber
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002683224A
Other languages
French (fr)
Other versions
CA2683224C (en
Inventor
Hosheng Tu
Gregory T. Smedley
David S. Haffner
Barbara A. Niksch
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaukos Corp
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23079551&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2683224(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Individual filed Critical Individual
Publication of CA2683224A1 publication Critical patent/CA2683224A1/en
Application granted granted Critical
Publication of CA2683224C publication Critical patent/CA2683224C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M27/00Drainage appliance for wounds or the like, i.e. wound drains, implanted drains
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007Methods or devices for eye surgery
    • A61F9/00781Apparatus for modifying intraocular pressure, e.g. for glaucoma treatment

Abstract

The invention relates generally to medical devices and methods for reducing the intraocular pressure in an animal eye and, more particularly, to stent type devices for permitting aqueous outflow from the eye's anterior chamber and associated methods thereof for the treatment of glaucoma. Some aspects provide a self-trephining glaucoma stent and methods thereof which advantageously allow for a "one-step" procedure in which the incision and placement of the stent are accomplished by a single device and operation. This desirably allows for a faster, safer, and less expensive surgical procedure.

Description

SYSTEM AND METHODS THEREOF FOR TREATMENT OF OCULAR DISORDERS
Backaround of the Invention Fietd of the Invention The invention relates generally to medical devices and methods for reducing the intraocular pressure ' in an animal eye and, more particulady, to shunt type devices for perinitting aqueous outfbw from the eye's anterior chamber and associated methods thereof for tle treatment of glaucoma.
Art Detcriotion of the Related The human eye is a specialized sensory organ capable of light reception and able to receive visual images: The trabecular meshwork serves as a drainage channel and Is located in anterbr chamber angle formed between the iris and the c,omea The trabecular meshwork maintains a balanced pressure in the anterior chamber of the eye by draining aquem humor from the anterior chamber.
About two percent of people In fhe United States have glaucoma Glaucoma is a group of eye diseases encompassing a broad spectrum of ciinicai presentations,. etiobgies, and treatment modalitf~es.
Glaucoma causes pathological changes in the optic nerve, visible on the optic disk, and it causes corresponding visual field loss, resulting in bqndness if untreated. Lowering intraocular pressure is the major treatment goal in al1 glaucomas.
1n glaucomas associated with an elevatlon in eye pressure (intraocular hypertension), the source of resistance to outflow is mainly in the trabecular meshwork. The tissue of the trabecular meshwork albws the aqueous humor ("aqueous') to enter Schlemm's canat, which then empties into aqueous collector channels im the posterior waU of Schlemm's canal and then into aqueous veins, which form the episclerat venous system.
Aqueous humor is a transparent nquid ihat fills the region between the comea, at the frord of the eye, and ft lens. The aqueous humor Is continuously secreted by the citiary body around the lens, so there is a constant flow of aqueous humor from the ciliary body to the eye's front chamber. The eye's pressure is determined by a balance between the production of aqueous and its exit through the trabecufar meshwork (major mute) or uveal sclerat outflow (minor route). The trabecular meshwork is located between the outer rim of the iris and the back of the comea, in the anterior chamber angle. The portlon of the trabecular meshwork adjacent to Schlemm's canal (the juxtacaniliculau meshwork) causes most of the resistance to aqueous. outfbw.
Glaucoma is grossly classified into two categories: closed-angle glaucoma, also known as angle closure glaucoma, and open-angle glaucoma. Closed-angle glaucoma is caused by closure of the anterior = chamber angle by contact between the iris and the inner surface of the trabecular meshwork. Closure of this anatomical angle prevents normai drainage of aqueous humor from the anterior chamber of the eye.
Open-angle glaucoma is any glaucoma in which the angle of the anterior chamber remains open, but the exit of aqueous through the trabecular meshwork is diminished. The exact cause for diminished filtration is unknown for most cases of open-angle glaucoma. Primary open-angle glaucoma is the most common of the glaucomas, and it is often asymptomatic in the early to moderately advanced stage. Patients may suffer substantial, irreversible vision loss prior to diagnosis and treatment.
However, there are secondary open-angle glaucomas which may include edema or swelling of the trabecular spaces (e.g., from corticosteroid use), abnormal pigment dispersion, or diseases such as hyperthyroidism that produce vascular congestion.
Current therapies for glaucoma are directed at decreasing intraocular pressure. Medical therapy includes topical ophthalmic drops or oral medications that reduce the production or increase the outtlow of aqueous. However, these drug therapies for glaucoma are sometimes associated with significant side effects, such as headache, blurred vision, allergic reactions, death from cardiopulmonary complications, and potential interactions with other drugs. When drug therapy fails, surgical therapy is used. Surgical therapy for open-angle glaucoma consists of laser trabeculoplasty, trabeculectomy, and implantation of aqueous shunts after failure of trabeculectomy or if trabeculectomy is unlikely to succeed.
Trabeculectomy is a major surgery that is widely used and is augmented with topically applied antlcancer drugs, such as 5-ffurouracil or mitomycin-C
to decrease scarring and increase the likelihood of surgical success.
Approximately 100,000 trabeculectomiea are performed on Medicare-age patients per year in the United States. This number would likely increase if the morbidity associated with trabeculectomy could be decreased. The current morbidity associated with trabeculectomy consists of failure (10-15%); infection (a life long risk of 2-5%); choroidal hemorrhage, a severe intemaf hemorrhage from low intraocular pressure, resulting in visual loss (1%); cataract formation; and hypotony maculopathy (potentially reversible visual loss from low intraocular pressure).
For these reasons, surgeons have tried for decades to develop a workable surgery for the trabecular meshwork.
The surgical techniques that have been tried and practiced are goniotomyltrabeculotomy and other mechanical disruptions of the trabecular meshwork, such as trabeculopuncture, goniophotoablation, laser trabecular ablation, and goniocurretage: These are all major operations and are briefly described below.
Goniotomy/Trabecufotomy. Goniotomy and trabeculotomy are simple and directed techniques of microsurgical dissectron with mechanical disruption of the trabecular meshwork. These initially had early favorable responses in the treatment of open-angle glaucoma. However, long-term review of surgical results showed only limited success in adults. In retrospect, these procedures probably failed due to cellular repair and fibrosis mechanisms and a process of "filling in." Filling in is a detrimental effect of collapsing and closing in of the created opening in the trabecular meshwork. Once the created openings close, the pressure builds back up and the surgery fails.
Trabeculopuncture: Q-switched Neodynium (Nd) YAG lasers also have been investigated as an optically invasive technique for creating full-thickness holes in trabecular meshwork. However, the relatively small hole created by this trabeculopuncture technique exhibits a filling-in effect and fails.
GoniophotoabtatioM.aser Trabecular Ablation: Goniophotoablation is disclosed by Beriin in U.S.
Patent No. 4,846,172 and involves the use of an excimer laser to treat glaucoma by ablating the trabecular meshwork. This was demonstrated not to succeed by clinical trial. Hill et al.
used an Erbium:YAG laser to = create full-thickness holes through trabecular meshwork (Hill et al., Lasers in Surgery and Medicine 11:341-346, 1991). This technique was investigated in a primate model and a limited human clinical trial at the University of Catifomia, Irvine. Although morbidity was zero in both trials, success rates did not warrant further human trials. Failure was again from filling in of surgically created defects in the trabecular meshwork by repair mechanisms. Neither of these is a viable surgical technique for the treatment of glaucoma.
Goniocurretage: This is an ab intemo (from the inside), mechanically disruptive technique that uses an instrument similar to a cyclodialysis spatula with a microcurrette at the tip. Initial results were simNar to trabeculotomy: it failed due to repair mechanisms and a process of filling in.
Although trabeculectomy is the most commonly performed flitering surgery, viscocanulostomy (VC) and non-penetrating trabeculectomy (NPT) are two new variaations of filtering surgery. These are ab extemo (from the outside), major ocular procedures in which Schlemm's canal is surgically exposed by making a large and very deep scleral flap: In the VC pnxedure, Schlemm's canal is cannulated and viscoelastic substam injected (which dilates Schlemm's canal and the aqueous couector channels). In the NPT procedure, the inner wall of Schlemm's canal is stripped off after surgically exposing the canal.
Trabeculectomy, VC, and NPT involve the formation of an opening or hole under the conjunctiva and scleral flap into the anterior chamber, such that aqueous humor is drained onto the surface of the eye or into the tissues bcated within the lateral wall of the eye. These surgica!
operations are major pnxedures vrith signficant ocular morbidity. When trabeculectomy, VC, and NPT are thought to have a low chance for success, a number of implantable drainage devices have been used to ensure that the desired ffltration and outflow of aqueous humor through the surgicW opening will continue. The risk of placing a glaucoma drainage device also includes hemorrhage, infection, and diplopia (double vision).
Examp4es of implantable shunts and surgical methods for maintaining an opening for the release of aqueous humor from the anterior chamber of the eye to the sciera or space beneath the conjunctiva have been disclosed in, for example, U.S. Patent No. 6,059,772 to Hsia et al., and U.S. Patent No. 6,050,970 to Baerveldt.
All of the above surgeries and variations thereof have numerous disadvantages and moderate success rates. They involve substantial trauma to the eye and require great surgical skill in creating a hole through the full thickness of the sclera into the subconjunctival space. The procedures are generally performed in an operating room and have a profonged recovery time for vision.
The complications of existing filtration surgery have prompted ophthalmic surgeons to find other approaches to lowering intraocular pressure.

.3-The trabecular meshwork and juxtacanilicular tissue together provide the majority of resistance to the outtlow of aqueous and, as such, are logical targets for surgical removal in the treatment of open-angle glaucoma. In addition, minimal amounts of tissue are altered and existing physiologic outflow pathways are utilized.

As reported in Arch. Ophthalm. (2000) 118: 412, glaucoma remains a leading cause of blindness, and filtration surgery remains an effective, important option in controlling the disease. However, modifying existing filtering surgery techniques in any profound way to increase their effectiveness appears to have reached a dead end. The article further states that the time has come to search for new surgical approaches that to may provide better and safer care for patients with glaucoma.

Therefore, there is a great clinical need for a method of treating glaucoma that is faster, safer, and less expensive than currently available modalities.

Summan- of the Invention The trabecular meshwork and juxtacanilicular tissue together provide the majority of resistance to the outflow of aqueous and, as such, are logical targets for surgical approach in the treatment of glaucoma. Various embodiments of glaucoma shunts are disclosed herein for aqueous to exit through the trabecular meshwork (major route) or uveal scleral outflow (minor route) or other route effective to reduce intraocular pressure (IOP).

Glaucoma surgical morbidity may be greatly decreased if one were to bypass the focal resistance to outflow of aqueous only at the point of resistance, and to utilize remaining, healthy aqueous outflow mechanisms. This is in part because episcieral aqueous humor exerts a backpressure that prevents intraocular pressure from going too low, and one could thereby avoid hypotony. Thus, such a surgery may reduce the risk of hypotony-related maculopathy and choroidal hemorrhage. Furthermore, visual recovery would be very rapid, and the risk of infection would be very small, reflecting a reduction in incidence from 2-5% to about 0.05%.

US 6,638,239 issued October 28, 2003 entitled APPARATUS AND METHOD
FOR TREATING GLAUCOMA, and US 6,736,791, issued May 18, 2004, entitled 3o GLAUCOMA TREATMENT DEVICE, disclose devices and methods of placing a trabecular shunt ub interno, i.e., from inside the anterior chamber through the trabecular meshwork, into Schlemm's canal. The invention encompasses both ab interno and ab externo glaucoma shunts or stents and methods thereof.

Techniques performed in accordance with aspects herein may be referred to generally as "trabecular bypass surgery." Advantages of this type of surgery include lowering intraocular pressure in a manner which is simple, effective, disease site-specific, and can potentially be perfonned on an outpatient basis.

Generally, trabecular bypass surgery (TBS) creates an opening, a slit, or a hole through trabecular meshwork with minor microsurgery. TBS has the advantage of a to much lower risk of choroidal hemorrhage and infection than prior techniques, and it uses existing physiologic outflow mechanisms. In some aspects, this surgery can potentially be performed under topical or local anesthesia on an outpatient basis with rapid visual recovery. To prevent "filling in" of the hole, a biocompatible elongated device is placed within the hole and serves as a stent. U.S. 6,638,239 issued October 28, is 2003, discloses trabecular bypass surgery.

As described in U.S. 6,638,239, issued October 28, 2003, and U.S. 6,736,791, issued May 18, 2004, a trabecular shunt or stent for transporting aqueous humor is provided. The trabecular stent includes a hollow, elongate tubular element, having an inlet section and an outlet section. The outlet section may optionally include two 20 segments or elements, adapted to be positioned and stabilized in side Schelmm's canal.
In one embodiment, the device appears as a"T" shaped device.

In one aspect of the invention, a delivery apparatus (or "applicator") is used for placing a trabecular stent through a trabecular meshwork of an eye. Certain embodiments of such a delivery apparatus are disclosed in copending U.S.
Application 25 No. 10/101,548, published September 19, 2002 as US 2002/0133168 Al (Inventors:
Gregory T. Smedley, Irvine, California, Morteza Gharib, Pasadena, California, Hosheng Tu, Newport Beach, California; Attorney Docket No.: GLAUKO. 012A), filed March 18, 2002, entitled APPLICATOR AND METHODS FOR PLACING A
TRABECULAR SHUNT FOR GLAUCOMA TREATMENT. The stent has an inlet 30 section and an outlet section. The delivery apparatus includes a handpiece, an elongate tip, a holder and an actuator. The handpiece has a distal end and a proximal end. The elongate tip is connected to the distal end of the handpiece. The elongate tip has a distal portion and is configured to be placed through a corneal incision and into an anterior chamber of the eye. 'fhe holder is attached to the distal portion of the elongate tip. The holder is configured to hold and release the inlet section of the trabecular stent. The actuator is on the handpiece and actuates the holder to release the inlet section of the trabecular stent from the holder. When the trabecular stent is deployed from the delivery apparatus into the eye, the outlet section is positioned in substantially opposite directions inside Schlemm's canal. In one embodiment, a deployment mechanism within the delivery apparatus includes a push-pull type plunger.

-o Some aspects of the invention relate to devices for reducing intraocular pressure by providing outflow of aqueous from an anterior chamber of an eye. The device generally comprises an elongated tubular member and cutting means. The tubular member is adapted for extending through a trabecular meshwork of the eye. The tubular member generaily comprises a lumen having an inlet port and at least one outlet port 1s for -o-providing a flow pathway. The cutting means is mechanically connected to or is an integral part of the tubular member for creating an incision in the trabecular meshwork for receiving at least a portion of the tubular member.
In one nspect, a seif-trephining glaucoma stent is provided for reducing andlor balancing intraocular pressure in an eye. The stent generally comprises a snorkel and a curved blade. The snorkel generally comprises an upper seat for stabilizing said stent within the eye, a shank and a lumen. The shank is mechanically connected to the seat and is adapted for extending through a trabecular meshwork of the eye. The lumen extends through the snorkel and has at least one inlet flow port and at least one outlet flow port. The blade is mechanically connected to the snorkel. The blade generally comprises a cutting tip proximate a distal-most point of the blade for making an incision in the trabecular meshwork for receiving the shank.
ln another aspect, the invention provides an implant for reducing intraocular pressure by providing outflow of aqueous humor from the anterior chamber of an eye, comprising: a seat for stabilizing the implant within the eye; a shank having a longitudinal axis and being connected to the seat and adapted to extend through a tissue of the eye; a lumen extending through the seat and shank and having at least one inlet port and at least one outlet port; an outlet section at the outlet port end of the shank having at least two outlet channels; wherein the implant is configured to be placed in the eye such that the outlet section resides in a physiologic outflow pathway of the eye, the shank extends through the tissue of the eye and the seat resides in the anterior chamber of the eye, so that aqueous humor can, in use, flow from the anterior chamber into the lumen through the inlet port and then through the outlet port and the outlet channels into the physiologic outflow pathway.
[n another aspect, the invention provides an implant for treating glaucoma, the implant comprising: an inlet portion configured to be positioned in the anterior chamber of an eye; and an outlet portion in fluid communication with the inlet portion, the outlet portion configured to be positioned at least partially in a physiologic outflow pathway of the eye;
wherein the outlet portion comprises a head portion comprising a first outlet opening along a surface of said head portion, said first outlet opening being in fluid communication with said outlet and inlet portions; and wherein a maximum dimension of said head portion is no greater that about a factor of two compared to a minimum distance between a distal end of said head portion and a proximal portion of said head portion.

In another aspect, the invention provides a system for treating an ocular disorder, comprising: an implant having an inlet portion and an outlet portion, a lumen extending between the inlet portion and the outlet portion and communicating with inlet and outlet ports, the implant sized so that in use aqueous humor flows from an anterior chamber of an eye into the lumen through the inlet port and then through the outlet port and into a uveal scleral outflow path of the eye; and a delivery device configured to advance the implant from within the anterior chamber, with the outlet portion leading the inlet portion, to a location where the outlet port communicates with the uveal scleral outflow path and the inlet port communicates with the anterior chamber.
Some aspects of the invention relate to methods of implanting a trabecular stent device in an eye. In one aspect, the device has a snorkel mechanically connected to a blade.
The blade is advanced through a trabecular meshwork of the eye to cut the trabecular meshwork and form an incision therein. At least a portion of the snorkel is inserted in the incision to implant the device in the eye.
In one aspect, the invention provides a method of lowering intraocular pressure within an eye of a mammal, comprising: providing a delivery device having at least a non-linear portion; providing an implant having at least one inlet and at least one outlet connected to the inlet by at least one pathway through the implant; inserting the non-linear portion of the delivery device into an anterior chamber of the eye; using the delivery device to move tha implant through a portion of the anterior chamber and into eye tissue to a position where the inlet is disposed within the anterior chamber and the outlet is disposed to drain fluid to a physiologic outflow pathway of the eye.
In another aspect, the invention provides use of a delivery device and an implant for lowering intraocular pressure within an eye of a mammal, wherein: the delivery device has at least a non-linear portion and is configured to position the implant so that it fluidicly communicates with a physiologic outflow pathway of the eye, and the implant has at least one inlet and at least one outlet connected to the inlet by at least one pathway through the implant, and the implant further has a cutting end configured to penetrate eye tissue.
In yet another aspect, the invention provides use of a delivery device and an implant that drains aqueous humor from an anterior chamber of an eye to a uveal scleral outflow path of the eye for implanting the implant into eye tissue from a location within the anterior chamber.

Some aspects provide a self-trephining glaucoma stent and methods thereof which advantageously allow for a "one-step" procedure in which the incision and placement of the stent are accomplished by a single device and operation. This desirably allows for a faster, safer, and less expensive surgical procedure. In any of the embodiments, fiducial markings, indicia, or the like and/or positioning of the stent device in a preloaded applicator may be used for proper orientation and alignment of the device during implantation.
Among the advantages of trabecuiar bypass surgery is its simplicity. The microsurgery may potentially be performed on an outpatient basis with rapid visual recovery and greatly decreased morbidity. There is a lower risk of infection and choroidal hemorrhage, and there is a faster recovery, than with previous techniques.
For purposes of summarizing the invention, certain aspects, advantages and novel features of the invention have been described herein above. Of course, it is to be understood that not necessarily all such advantages may be achieved in accordance with any particular embodiment of the invention. Thus, the invention may be embodied or carried out in a manner that achieves or optimizes one advantage or group of advantages as taught or suggested herein without necessarily achieving other advantages as may be taught or suggested herein.
All of these embodiments are intended to be within the scope of the invention herein disclosed. These and other embodiments of the invention will become readily apparent toa those skilled in the art from the following detailed description of the preferred embodiments having reference to the attached figures, the invention not being limited to any particular preferred embodiment(s) disclosed.

Brief DescrioNon of the Orawings Having thus summarized the general nature of the invention and some of its features and advantages, certain preferred embodiments and modifications thereof wiii become apparent to those skilled in the art from the detailed description herein having reference to the figures that follow, of which:
FIG. 1 is a coronal cross-sectional view of an eye;
FIG. 2 is an enlarged cross-sectionai view of an anterior chamber angle of the eye of FIG. 1;
FIG. 3 is a simplified partiai view of an eye iNustrating the implantation of a glaucoma stent having features and advantages in accordance with one embodiment of the invention;
FIG. 4 is a side elevation view of the stent of FIG. 3;
FIG. 5 is a top plan view of the stent of FIG. 3;
FIG. 6 is a bottom plan view of the stent of FIG. 3;
FIG. 7 Is a front end view of the stent of FIG. 3 (along line 7-7 of FIG. 4);
FIG. 8 is a rear end view of the stent of FIG. 3(abng line 8-8 of FIG. 4};
FIG. 9 is an enlarged top plan view of a cutting tlp of the stent of FIG. 3;
15, FIG. 10 is a top plan view of one exemptary embodiment of a snorkel top seating surface;
FIG. 11 is a top plan view of another exemplary embodiment of a snorkei top seating surface;
FIG. 12 is a top plan view of yet another exemplary embodiment of a snorkel top seating surface;
FIG. 13 is a top plan view of stiN another exempiary embodiment of a snorkel top seating surface;
FIG. 14 is a simptified partlat view of an eye iilustrating the implantation of a glaucoma stent having features and advantages in ac.cordance with aneother embodiment of the invention;
FIG. 15 is a simplified partial view of an eye iiiustrating the implantation of a glaucoma stent having features and advantages in acxordance with a further embodiment of the invention;
FiG.16 is a side elevation view of a glaucoma stent having features and advantages in accordance with one embodiment of the invention;
FIG.17 is a top plan view of the stent of FIG. 16;
FIG.18 is a bottom plan view of the stent of FIG. 16;
FIG. 19 is a front end view along line 19-19 of FIG.16;
FIG. 20 is a rear end view along line 20-20 of FIG. 16;
FIG. 21 is a side elevation view of a glaucoma stent having features and advantages in accordance with one embodiment of the invention;
= FIG. 22 is a top plan view of the stent of FIG. 21;
FIG. 23 is a bottom plan view of the stent of FIG. 21;
FIG. 24 is a front end view along line 24-24 of FIG. 21;
FIG. 25 is a rear end view along line 25-25 of FIG. 21;

FIG. 26 is a front eievation view of a glaucoma stent having features and advantages in accordance with one embodiment of the invention;
FIG. 27 is a side elevation view along line 27-27 of FIG. 26;
FIG. 28 is a rear end view along line 28-28 of FIG. 26;
FIG. 29 is a simplified partiai view of an eye iliustrating the temporal implantation of a glaucoma stent using a delivery apparatus having features and advantages in accordance with one embodiment of the invention;
FIG. 30 is an oblique elevational view of an articulating arm stent delivery/retrieval apparatus having features and advantages in accordance with one embodiment of the invention;
FIG. 31 is a simplified partlai view of an eye iuustrating the implantation of a glaucoma stent using a delivery apparatus crossing through the eye anterior chamber FIG. 32 is a simpiified partiat view of an eye illustrating the impiantation of a glaucoma stent having features and advantages In accordance with one embodiment of the invention;
FIG. 33 is a detailed enlarged view of the barbed pin of FIG. 32;
FIG. 34 is a simplified partiat view of an eye illustrating the impiantation of a glaucoma stent having features and advantages in acconiance with one embodiment of the invention;
FIG. 35 is a simplified partiat view of an eye iliustrating the implantation of a glaucoma stent having features and advantages in accordance with one embodiment of the inventiorr, FIG. 36 is a simplifled partiat view of an eye iilustrating the imptantation of a glaucoma stent having features and advantages in accordance with one embodiment of the inventiw FIG. 37 is a simpi'fied parbat view of an eye illustrating the implantation of a glaucoma stent having features and advantages in accordance with one embodiment of the inventwn;.
FIG. 38 is a simplified partiai view of an eye illustrating the impiantation of a glaucoma stent having features and advantages in accordance with one embodiment of the invention;
FIG. 39 is a simplified partial view of an eye illustrating the implantation of a glaucoma stent having features and advantages in accordance with one embodiment of the invenaon;
FIG. 40 is a simplified partial view of an eye illustrating the implantation of a glaucoma stent having features and advantages in accordance with one embodiment of the invention;
FIG. 41 is a simplified partial view of an eye illustrating the implantation of a glaucoma stent having features and advantages in accordance with one embodiment of the invention;
FIG. 42 is a simplified partial view of an eye illustrating the implantation of a glaucoma stent having features and advantages in accordance with one embodiment of the invention;
FIG. 43 is a simplified partial view of an eye illustrating the implanta6on of a valved tube stent device having features and advantages in accordance with one embodiment of the invention;

FIG. 44 is a simplified partial view of an eye illustrating the implantation of an osmotic membrane device having features and advantages in accordance with one embodiment of the invention;
FIG. 45 is a simplified partiai view of an eye iiiustrating the implantation of a glaucoma stent using ab extemo procedure having features and advantages in accordance with one embodiment of the invention;
FIG. 46 is a simplified partial view of an eye iliustrating the implantation of a glaucoma stent having features and advantages in accordance with a modified embodiment of the invention; and FIG. 47 is a simplified partial view of an eye iltustrating the impiantation of a drug release implant having features and advantages in accordance with one embodiment of the invention.
Detailed Descriotion of the Preferred Embodimentf The preferred embodiments of the invention described herein relate particuiariy to surgical and therapeutic treatment of glaucoma through reduction of intraocular pressure, While the descripti~on sets forth various embodiment specific details, it wiu be appreciated that the description is iitustrative only and should not be construed in any way as limiting the invention. Furthermore, various applications of the invention, and modifications thereto, which may occur to those who are skilled in the art, are also encompassed by the generai concepts described herein.
FIG. I is a cross-secbonal view of an eye 10, while FIG. 2 is a close-up view showing the reiative anatomical locations of a trabecular meshwork 21, an anterior chamber 20, and Schlemm's canal 22. A
sclera 11 is a thick coitagenous tissue which covers the entire eye 10 except a portion which is covered by a comea 12.
Referring to FIGS.1 and 2, the comea 12 is a thin transparent tissue that focuses and tran,smits ight:
into the eye and through a pupil 14, which is a circular hole in the center of an iris 13 (colored portion of the eyej. The comea 12 merges Into the sclera 11 at a juncture referred to as a limbus 15. A ciiiary body 16 extends along the interior of the sclera 11 and is coextensive with a choroid 17. The choroid 17 is a vascular layer of the eye 10, located between the sciera 11 and a re6na 18, An optic nerve 19 transmits visual information to the brain and is the anatomic structure that is pmgcessively destroyed by glaucoma.
StiN refening to FIGS. 1 and 2, the anterior chamber 20 of the eye 10, which is bound anterioriy by the comea 12 and posterioriy by the iris 13 and a lens 26, is filled with aqueous humor (hereinafter referred to as "aqueous'). Aqueous is produced primarily by the ciliary body 16, then moves anteriorly through the pupil 14 and reaches an anterior chamber angle 25, formed between the iris 13 and the comea 12.
As best illustrated by the drawing of FIG. 2, in a normal eye, aqueous is removed from the anterior = chamber 20 through the trabecular meshwork 21. Aqueous passes through the trabecular meshwork 21 into Schlemm's canal 22 and thereafter through a plurality of aqueous veins 23, which merge with blood-carrying veins, and into systemic venous circulation. Intraocular pressure is maintained by an intricate balance between secretion and outflow of aqueous in the manner described above.
Glaucoma is, in most cases, characterized by an excessive buildup of aqueous in the anterior chamber 20 which leads to an increase in intraocular pressure. Fluids are relatively incompressible, and thus intraocular pressure is distributed reiativeiy uniformly throughout the eye 10.
As shown in FIG. 2, the trabecular meshwork 21 is adjacent a smali portion of the sclera 11. Exterior to the sclera 11 is a conjunctiva 24. Traditional procedures that create a hole or opening for impianang a device through the tissues of the conjunctiva 24 and sclera 11 involve extensive surgery by an ab extemo procedure, as compared to surgery for implanting a device, as described herein, which uitimateiy resides entireiy within the confines of the sciera 11 and comea 12.
SeN treohinino Giaucoma Stent FIG. 3 generally illustrates the use of one embodiment of a trabecular stenting device 30 for establishing an outflow pathway, passing through the trabecular meshwork 21, which is discussed in greater detal below. FIGS. 4-9 are different views of the stent 30. Advantageously, and as discussed In further detaii later herein, the selt tn:phining-stent allows a one-step procedure to make an incision in the trabecuiar mesh 21 and piace the stent or implant 30 at the desired or predetermined position within the eye 10. Desirably, this faciiitates and simplifies the overall surgical procedure.
In the illustrated embodiment of FIGS. 3-9, the shunt or stent 30 generally comprises a snorkei 32 and a main body pordon or blade 34. The snorkel 32 and blade 34 are mechanically connected to or in mechanicaF communication with one another. The stent 30 andlor the body portion 34 have a generally longitudinai axis 36.
In the illustrated embodiment of FIGS. 3-9, the stent 30 comprises an integra[
unit~: In modified embodiments, the stent 30 may comprise an assembly of individuai pieces or componentx For exampie; tht, stent 30 may comprise an assembly of the snorkel 32 and blade 34.
In the iltustrated embodiment of FIGS. 3-9, the snorkel 32 is in the form of a generally elongate tubular member and generally comprises an upper seat, head or cap portion 38, a shank portion 40 and a lumen or passage 42 extending therethrough. The seat 38 is mechanically connected to or in mechanicai communication with the shank 40 which is also mechanically connected to or in mechanical communication with the blade 34. The snorkel 32 andlor the lumen 42 have a generally longitudinal axis 43.
In the illustrated embodiment of FIGS. 3-9, the seat 38 is generally circular in shape and has an upper surface 44 and a lower surface 46 which, as shown in FIG. 3, abuts or rests against the trabecular meshwork 21 to stabilize the glaucoma stent 30 within the eye 10. In modified embodiments, the seat 38 may efficaciously be shaped in other suitable manners, as required or desired, giving due consideration to the goals of stabilizing the glaucoma stent 30 within the eye 10 andlor of achieving one or more of the benefits and advantages as taught or suggested herein. For example, the seat 38 may be shaped in other polygonal or non-polygonal shapes and/or comprise one or more ridges which extend radially outwards, among other suitable retention devices.

In the illustrated embodiment of FIGS. 3-9, and as best seen in the top view of FIG. 5, the seat top surface 44 comprises fiducial marks or indicia 48. These marks or indicia 48 facilitate and ensure proper orientation and alignment of the stent 30 when implanted in the eye 10. The marks or indicia 48 may comprise visual differentiation means such as color contrast or be in the form of ribs, grooves, or the like.
Altemat'rvely, or in addition, the marks 48 may provide tactile sensory feedback to the surgeon by incorporating a radiopaque detectable or ultrasound imaginable substrate at about the mark 48. Also, the seat 38 and/or the seat top surface 44 may be configured in predetermined shapes aligned with the blade 34 and/or kxVitudinat axis 36 to provide for proper orientation of the stent device 30 within the eye 10. For example, the seat top surface 44 may be oval or ellipsoidal (FIG. 10), rectangular (FIG. 11), hexagonat (FIG.
12), among other suitabte shapes (e.g. F{G.13).
In the illustrated embodiment of FIGS. 3-9, and as indicated above, the seat bottom surface 46 abuts or m,sts against the trabecular meshwork 21 to stabilize and retain the glaucoma stent 30 within the eye 10.
For stabilization purposes, the seat bottom surface 46 may comprise a stubbed surface, a ribbed surface, a surface with pillars, a textured surface, or the like.
In the illustrated embodiment of FIGS. 3-9, the snorkel shank 40 is generally cyGndrfcat in shape.
With the stent 30 implanted, as shown in FIG. 3, the shank 40 is generally positioned in an incision or cavity 50 formed in the trabecular meshworlc 21 by the self-trephining stent 30.
Advantageously, and as discussed further below, this single step of forming the cavity 50 by the stent 30 itself and placing the stent 30 in the desired position facilitates and expedites the overaN surgicat pmcedure. In modified embodiments. the snorkel shank 40 may efficaciously be shaped In other suitabte manners, as required or desired. For example, the shank 40 may be in the shape of other polygonal or non-polygonal shapes, such as, ovat, ellposoidal, and the like:
In the illustrated embodiment of FIGS. 3-9, and as best seen in FIG. 3, the shank 40 has an outer surface 52 in contact with the trabecular meshwork 21 surrounding the cavity 50. For stabilization purposes, the shank outer surface 52 may comprise a stubbed surface, a ribbed surface, a surface with pillars, a textured surface, or the like.
In the illustrated embodiment of FIGS. 3-9, the snorkel lumen 42 has an inlet port, opening or orifice 54 at the seat top surface 44 and an outlet port, opening or orifice 56 at the junction of the shank 40 and blade 34. The lumen 42 is generally cylindrical in shape, that is, it has a generally circular cross-section, and its ports 54, 56 are generally circular in shape. In modified embodiments, the lumen 42 and ports 54, 56 may be efficaciously shaped in other manners, as required or desired, giving due consideration to the goals of providing sufficient aqueous outflow and/or of achieving one or more of the benefits and advantages as taught or suggested herein. For example, the lumen 42 and/or one or both ports 54, 56 may be shaped in the form of ovals, ellipsoids, and the like, or the lumen 42 may have a tapered or stepped configuration.

Referring in particular to F1G. 3, aqueous from the anterior chamber 20 flows into the lumen 42 through the inlet port 54 (as generally indicated by arrow 58) and out of the outtet port 56 and into Schlemm's canal 22 (as generally indicated by arrows 60) to lower and/or balance the intraocular pressure (IOP). In another embodiment, as discussed in further detail below, one or more of the outlet ports may be configured to face in the general direction of the stent longitudinal axis 36. In modified embodiments, the snorkel 32 may comprise more than one lumen, as needed or desired, to facilitate muitiple aqueous outfiow transportation into Schlemm's canal 22.
In the illustrated embodiment of FIGS. 3-9, the blade longitudinal axis 36 and the snorkel longitudinal axis 43 are generally perpendicular to one another. Stated differentiy, the projections of the axes 36, 43 on a common plane which is not perpendicular to either of the axes 36, 43 intersect at 90 . The blade longitudinal axis 36 and the snorkel longitudinal axis 43 may intersect one another or may be offset from one another.
In the illustrated embodiment of FIGS. 3-9, the main body portion or blade 34 is a generally curved elongated sheet- or plate-like stnacture with an upper curved surface 62 and a lower curved surface 64 whicft defines a trough or open face channel 66. The perimeter of the blade 34 is generaUy defined by a curved proximal edge 68 proximate to the snorkel 32, a curved distal edge 70 spaced from the proximal edge 68 by a pair of generally straight lateral edges 72, 74 with the first lateral edge 72 extending beyond the second lateral edge 74 and intersecting with the distal edge 70 at a distal-most point 76 of the blade 34 proximate a blade culting t;p 78.
In the illustrated embodiment of FIGS: 3-9, and as shown in the enlarged view of FIG. 9, the cutting tip 78 comprises a first cutting edge 80 on ihe dtstal edge 70 and a second cuttN edge 82 on the lateral edga 72. The cutting edges 80, 82 preferably extend from the distal-most point 76 of the blade 34 and comprise at least a respective portion of the distal edge 70 and lateral edge 72. The respectivve cutting edges 80, 82 are formed at the sharp edges of respective beveled or tapered surfaces 84, 86. In one embodiment, the remainder of the distal edge 70 and lateral edge 72 are dull or rounded. In one embodiment, the tip 78 proximate to the distal-most end 76 is curved slightly inwards, as indicated generally by the arrow 88 in FIG. 5 and arrow 88 (pointed perpendicular and into the plane of the paper) in FIG.
9, relative to the adjacent curvature of the blade 34.
In modified embodiments, suitable cutting edges may be provided on selected portions of one or more selected blade edges 68, 70, 72, 74 with efficacy, as needed or desired, giving due consideration to the goals of providing suitable cutting means on the stent 30 for effectively cutCGng through the trabecular meshwork 21 (FIG. 3) and/or of achieving one or more of the benefits and advantages as taught or suggested herein.
Referring in particular to FIG. 9, in one embodiment, the ratio between the lengths of the cutting edges 80, 82 is about 2:1. In another embodiment, the ratio between the lengths of the cutting edges 80, 82 is about 1:1. In yet another embodiment, the ratio between the lengths of the cutting edges 80, 82 is about 1:2. In modified embodiments, the lengths of the cutting edges 80, 82 may be efficaciously selected in other manners, as required or desired, giving due consideration to the goals of providing suitable cutting means on the stent 30 for effectively cutting through the trabecular meshwork 21 (FIG.
3) and/or of achieving one or more of the benefits and advantages as taught or suggested herein.
S6tf referring in particular to FIG. 9, in one embodiment, the ratio between the lengths of the cutting edges 80, 82 is in the range from about 2:1 to about 1:2. In another embodiment, the ratio between the lengths of the cutting edges 80, 82 is in the range from about 5:1 to about 1:5. In yet another embodiment, the ratio between the lengths of the cut6ng edges 80, 82 is in the range from about 10:1 to about 1:10. In modified embodiments, the lengths of the cutting edges 80, 82 may be efficaciously selected in other manners, as required or desired, giving due consideration to the goals of providing suitable cutting means on the stent 30 for effectively cutfing through the trabecular meshwork 21 (FIG.
3) and/or of achieving one or more of the benefifs and advantages as taught or suggested herein.
As shown in the top view of FIG. 9, the cutting edge 80 (and/or the distal end 70) and the cutting edge 82 (and/or the lateral edge 72) intersect at an angle 9. Stated differentfy, 0 is the angle between the projections of the cutting edge 80 (and/or the distal end 70) and the cutting edge 82 (andlor the lateral edge 72) on a common plane which is not perpendicular to either of these edges.
Referring to in pardcular to FIG. 9, in one embodiment, the angle 9 is about 50 . In another embodiment, the angle 8 is in the range from about 40 to about 60 . In yet another embodiment, the angle 0 is in the range from about 30 to about 70'. In modified embodiments; the angle 0 may be ef6caciously.
selected In other manners, as required or desired, gmng due consideration to the goals of providing suitable cutting means on the stent 30 for effectively cutting through the trabecular meshwork 21 (FIG. 3) and/or of achieving one or more of the benefits and advantages as taught or suggested herein.
The stent 30 of the embodiments disclosed herein can be dimensioned in a wide variety of manners.
Referring in particular to FIG. 3, the depth of Schlemm's canal 22 Is typically about less than 400 microns ( m). Accordingly, the stunt blade 34 is dimensioned so that the height of the blade 34 (referred to as H4, in FIG. 4) is typically less than about 400 m. The snorkel shank 40 is dimensioned so that it has a length (referred to as L4, in FIG. 4) typically in the range from about 150 m to about 400 m which is roughly the typical range of the thickness of the trabecular meshwork 21.
Of course, as the skilled artisan will appreciate, that with the stent 30 implanted, the blade 34 may rest at any suitable position within Schlemm's canal 22. For example, the blade 34 may be adjacent to a front wall 90 of Schlemm's canal 22 (as shown in FIG. 3), or adjacent to a back wall 92 of Schlemm's canal 22, or at some intermediate location therebetween, as needed or desired. Also, the snorkel shank 40 may extend into Schlemm's canal 22. The length of the snorkel shank 40 and/or the dimensions of the blade 34 may be efficaciously adjusted to achieve the desired implant positioning.

raoncated by a-Hide variety of techniques. These include, without fimitation, by molding, thermo-forming, or other micro-machining techniques, antong other suitable techniques.
The trabecular stenting device 30 preferably comprises a biocompatible material such that inflammation arising due to irritation betvreert the outer surface of the device 30 and the surrounding tissue is minimized. Biocompatible materials which may be used for the device 30 preferably incfude, but are not limited to, titanium, titanium alloys, medical grade silicone, e.g., SilasticTM, available irom Dow Coming Corporation of Midland, Michigan; and poiyurethane, e.g., PellethaneTM, also available from Dow Coming Corporation.
In other embodiments, the stent device 30 may comprise other types of biocompatible material, such as, by way of example, polyvinyl ak.ohol, polyvinyi pyrolidone, collagen, heparinized coMagen, polytetrallkuoroethylene, expanded polytetrafluoroethyleene, ftuorinated polymer, fluorinated elastomer, flexible fused siAca, polyoletin, polyester, polysilicai, andtor a mixturo of the aforementkxted biocompatibie materia{s, and the {ike. In stiN other embodiments, composite biacompatibk material may be used, wherein a surface material may be used in additbn to one or more of the atorementioned materials. For example, such a surface material may include pohrtetrafluoroethylene (PTFE) (such as TefkmTM), polyimide, hydnogel, heparin, therapeutic drugs (such as beta-adrenergic antagonists and other anti-glaucoma drugs, or antibiotics), and the ',ike.
in an exemplary embodiment of the trabecular meshwork surgery, the patient is placed In the supine positlon, prepped, draped and anesthetized as necessary. In one embodiment, a smaq (less than about 1 mm) incision, which may be sel# sealing ls made through the comea 12. The comeal incision can be made in a number of ways, for example, by using a micro-knife, among other tools.
An applicator or delivery apparatus is used to advance the glaucoma stent 30 through the comeal incision and to the trabecular meshwork 21. Some embodiments of such a delivery apparatus are disclased in copending U.S. Application No. 10/101,548, published September 19, 2002 as (tnventors: Gregory T. Smedley, Irvine, California, Morteza Gharib, Pasadena, California, Hosheng Tu, Newport Beach, California; Attorney Docket No.: GLAUKO412A), filed March 18, 2002, entitled APPLICATOR AND METHODS FOR PLACINGA TRABECULAR SHUNT FOR GLAUCOMA
TREATMENT. Some embodiments of a delivery apparatus are also discussed in further detail later herein. Gonioscopic, microscopic, or endoscopic guidance may be used during the trabecular meshwork surgery.

'JVith the device 30 held by the delivery apparatus, the blade 34 of the selt trephining glaucoma stent device 30 is used to cut andlor displace the material of the trabecular meshwork 21. The snorkel shank 40 may also facilitate in removal of this material during implantation. The delivery apparatus is withdrawn once the device 30 has been implanted in the eye 10. As shown in FIG. 3, once proper implantation has been accomplished the snorkel seat 38 rests on a top surface 94 of the trabecular meshwork 21, the snorkel shank 40 extends thnwgh the cavity 50 (created by the device 30) in the trabecular meshwork 21, and the blade extends inside Schlemm's canal 22.
Advantageously, the embodiments of the setf-trephining stent device of the invention allow for a "one-step' procedure to make an incision in the trabecular meshwork and to subsequently implant the stent in the proper orientation and alignment within the eye to allow outflow of aqueous from the anterior chamber through the stent and into Schlemm's canal to lower and/or balance the intraocular pressure (IOP). Desirably, this provides for a faster, safer, and less expensive surgical pmcedure.
Many comptications can arise in trabecular meshwork surgerles, wherein a knife is first used to create an incision in the trabecular meshwork, folbwed by removal of the knife and subsequent installation of the stent. For instance, the knffe may cause some bleeding which clouds up the surg'icat site. This may require more effort and time to clean the surgical site prior to placement of the stent. Moreover, this may cause the intraocular pressure (IOP) to rise or to fall undesireably. Thus, undesirably, such a muitiple step procedure may demand crisis management which slows down the surgery, makes it less safe, and more expensive.
FIG. 14 is a simplified partial view of an eye 10 illustrattng the implantation of a self-trephining glaucoma stent device 30a having features and advantages in accordance with one embodiment. The stent 30a is generaAy similar to the stent 30 of FtG3. 3-9 except that its snorkel 32a comprises a longer shank 40a 21W- which extends into Schlemm's canal 22 and a lumen 42a which bifurcates into two output channels 45s.
In the illustrated embodiment of FIG. 14, the shank 40a terminates at the blade 34. Aqueous flows from the anterior chamber 20 into the lumen 42a through an inleE port 54a (as generaNy Indicated by arrow 58#: Aqueous then flows through the output channels 45a and out of respective outiet ports 56a and into Schlemm's canal 22 (as generally indicated by arrows 60a). The outlet channels 45a extend radially outwards in generally opposed directions and the outlet ports 56a are configured to face in the general direction of the stent longitudinal axis 36 so that they open into Schlemm's canal 22 and are in proper orientation to allow aqueous outflow into Schlemm's canal 22 for lowering and/or balancing the intraocular pressure (IOP). As indicated above, fiducial marks or indicia and/or predetermined shapes of the snorkel seat 38 allow for proper orientation of the blade 34 and also the output channels 45a and respective ports 56a within Schlemm's canal.
In the illustrated embodiment of FIG. 14, two outflow channels 45a are provided. In another embodiment, only one outflow channel 45a is provided. In yet another embodiment, more than two outfiow channels 45a are provided. In modified embodiments, the lumen 42a may extend all the way through to the blade 34 and provide an outlet port as discussed above with reference to the embodiment of FIGS. 3-9.

FIG. 15 Is a simplified parpal view of an eye 10 illustrating the implantation of a self-trephining glaucoma stent device 30b having features and advantages in accordance with one embodiment. The stent 30b is generally similar to the stent 30 of FIGS. 3-9 except that its snorkel 32b comprises a longer shank 40b which extends into Schlemm's canal 22 and a lumen 42b which bifurcates into two output channels 45b.
In the illustrated embodiment of FIG. 15, the shank 40b extends through the blade 34. Aqueous flows from the anterior chamber 20 into the lumen 42b through an inlet port 54b (as generally indicated by arrow 58b). Aqueous then flows through the output channels 45b and out of respective outiet ports 56b and into Schlemm's canal 22 (as generally indicated by arrows 60b). The outlet channels 45b extend radially outwards in generally opposed directions and the outlet ports 56b are configured to face in the general din3ction of the stent longitudinal axis 36 so that they open into Schlemm's canal 22 and are in proper orientation to allow aqueous outflow into Schlemm's canal 22 for kywering and/or balancing the intraocular pressure (IOP). As indicated above, fiduciai marks or indicia andlor predetermined shapes of the snorkel seat 38 allow for proper orientation of the blade 34 and also the output channels 45b and respecctive ports 56b within Schlemm's canal.
In the illustrated embodiment of FIG. 15, two outftow channels 45b are provided. In another embodiment, only one outflow channel 45b is provided. In yet another embodiment, more than two outflow channels 45b are provided. In modified embodiments, the lumen 42b may extend all the way through to the blade 34 and provide an outlet port as discussed above with reference to the embodiment of FIG3~. 3-9.
FlGS.16-20 show different views of a self-trephining glaucoma stent device 30c having features and advantages in accordance with one embodiment, The stent 30c is generally similar to the stent 30 of FIGS. 3.
9 except that it has a modified blade configurat'ronr. The stent 30c comprises a blade 34c which is a generally curved ekwgated sheet- or plate-like sWcture with an upper curved surface 62c and a lower curved surface 64c which defines a trough or open face channel 66c. The perimeter of the blade 34c is generally defined by a curved proximal edge 68c proximate to the snorkel 32, a curved distal edge 70c spaced fnom the proximal edge 68c by a pair of generally straight lateral edges 72c, 74c which are generally paranel to one another and have about the same length.
In the illustrated embodiment of FIGS. 16-20, the blade 34c comprises a cutting tip 78c. The cutting tip 78c preferably includes cutting edges formed on selected po-tions of the distal edge 70c and adjacent portions of the lateral edges 72c, 74c for cutting through the trabecular meshwork for placement of the snorkel 32. The cutting edges are sharp edges of beveled or tapered surfaces as discussed above in reference to FIG. 9. The embodiment of FIGS. 16-20 may be efficaciously modified to incorporate the snorkel configuration of the embodiments of FIGS. 14 and 15.
FIGS. 21-25 show different views of a self-trephining glaucoma stent device 30d having features and advantages in accordance with one embodiment. The stent 30d is generally similar to the stent 30 of FIGS.
3-9 except that it has a modified blade configuration. The stent 30d comprises a blade 34d which is a generally curved elongated sheet- or plate-like structure with an upper curved surface 62d and a lower curved surface 64d which defines a trough or open face channel 66d. The perimeter of the blade 34d is generally defined by a curved proximal edge 68d proximate to the snorkel 32, a pair of inwardly converging curved distal edges 70d', 70d" spaced from the proximaf edge 68d by a pair of generaUy straight respective lateral edges 72d, 74d which are generally parallel to one another and have about the same length. The distal edges 70d', 70d" intersect at a distal-most point 76d of the blade 34d proximate a blade cutting tip 78d.
In the illustrated embodiment of FIGS. 21-25, the cutting tip 78d preferably includes cutting edges formed on the distal edges 70d', 70d" and extending from the distal-most point 76d of the blade 34d. In one embodiment, the cutting edges extend along only a portion of n3spective distal edges 70d', 70d'. In another embodiment, the cutting edges extend along substantially the entire length of respective distal edges 70d', 70d`. In yet another embodiment, at least portions of the lateral edges 72d, 74d proximate to respectivve distaf edges 70d, 70d' have cutting edges. In a further embodiment, the tip 78d proximate to the distal-most enc!
76d is curved slightly inwards, as indicated generaNy by the arrow 88d in F1G.
21 and anvw 88d (pointecf perpendicular and into the plane of the paper) in FIG. 22, relatlve to the adjacent curvature of the blade 34d.
In the embodiment of FIGS. 21-25, the cutting edges are sharp edges of beveled or tapered surfaces as discussed above in reference to FIG. 9. The embodiment of F{GS. 21-25 may be efficaciously modified to incorporate the snorkel configuration of the embodiments of FIGS. 14 and 15.
FIGS. 26-28 show different views of a se{f-trephining glaucoma stent device 30e having features and advantages in acconiance with one embodiment. The stent device 30e generally comprises a snorkel 329 211-- mechanically connected to or in mechanical communication with a blade or cutting tip 34. The snorkel 32s has a seat, head or cap portion 38e mechanically connected to or in mechanical communication with a shank 40e, as discussed above. The shank 40e has a distal end or base 47e. The snorkel 32e further has a lumen 42e which bifun;ates into a pair of oudet channels 45e, as discussed above in connection with FIGS. 14 and 15. Other lumen and inlet and outlet port configurations as taught or suggested herein may also be efficaciously used, as needed or desired.
In the illustrated embodiment of FIGS. 26-28, the blade 34e extends downwardly and outwardly from the shank distal end 47e. The blade 34e is angled relative to a generally longitudinal axis 43e of the snorket 32e, as best seen in FIGS. 27 and 28. The blade 34e has a distal-most point 76e. The blade or cutting tip 34e has a pair of side edges 70e', 70e", including cutting edges, terminating at the distal-most point 76e, as best seen in FIG. 26. In one embodiment, the cutting edges are sharp edges of beveled or tapered surfaces as discussed above in reference to FIG. 9.
Referring to FIGS. 26-28, in one embodiment, the blade 34e includes cutting edges formed on the edges 70e, 70e" and extending from the distal-most point 76e of the blade 34d.
In one embodiment, the cutting edges extend along only a portion of respective distal edges 70e', 70e". In another embodiment, the cutting edges extend along substantially the entire length of respective distal edges 70e', 70e'. In yet another embodiment, the blade or cutting tip 34e comprises a bent tip of needle, for example, a 30 gauge needle.
In general, any of the blade configurations disclosed herein may be used in conjunction with any of the snorkel configurations disclosed herein or incorporated by reference herein to provide a self trephining glaucoma stent device for making an incision in the trabecular meshwork for receiving the corresponding snorkel to provide a pathway for aqueous outflow from the eye anterior chamber to Schlemm's canal, thereby effectively lowering andlor balancing the intraocular pressure (IOP). The seff-trephining ability of the device, advantageously, allows for a'one-step' procedure in which the incision and placement of the snorkel are accomplished by a single device and operation. In any of the embodiments, fiducial markings or indicia, andlor preselected configuration of the snorkel seat, andlor positioning of the stent device in a preloaded applicator may be used for proper orientation and alignment of the device during implantation.
Deliverv Apparatus In many cases, a surgeon works from a temporal incision when performing cataract or goniometry surgery. FIG. 29 illustrates a temporal implant procedure, wherein a delivery apparatus or "applicator' 100 having a curved tip 102 is used to deliver a stent 30 to a temporal side 27 of the eye 10. An incision 28 is made in the comea 10, as discussed above. The apparatus 100 is then used to introduce the stent 30 through the incision 28 and implant it within the eye 10.
Still refen-ing in particular to FIG. 29, in one embodiment, a similarly curved instrument would be used to make the incision through the trabecular meshwork 21. In other embodiments, a self-trephining stent device 30 may be used to make this incision through the trabecular meshwork 21, as discussed above. The temporal implantation procedure illustrated in FIG. 29 may be employed with the any of the various stent embodiments taught or suggested herein.
FIG. 30 illustrates one embodiment of an apparatus comprising an artculating stent applicator or retrieval device 100a. In this embodiment, a proximal arm 106 is attached to a distal arm 108 at a joint 112.
This joint 112 is movable such that an angle formed between the proximal arm 106 and the distal arm 108 can change. One or more claws 114 can extend from the distal arm 108, in the case of a stent retrieval device.
Similarly, this articulation mechanism may be used for the trabecular stent applicator, and thus the articulating appiicator or retrievai device 100a may be either an applicator for the trabecular stent, a retrieval device, or both, in various embodiments. The embodiment of FIG. 30 may be employed with the any of the various stent embodiments taught or suggested herein.
FIG. 31 shows another illustrative method for placing any of the various stent embodiments taught or suggested herein at the implant site within the eye 10. A delivery apparatus 100b generally comprises a syringe portion 116 and a cannula porfion 118. The distal section of the cannula 118 has at least one irrigating hole 120 and a distal space 122 for holding the stent device 30.
The proximal end 124 of the lumen of the distal space 122 is sealed from the remaining lumen of the cannula portion 118. The delivery herein.
In one aspect of the invention, a delivery apparatus (or "appticator"} is used for placing a trabecular stent thmwgh a trabecular meshwork of an eye. Certain embodiments of st,ch a deGvery apparatus are g disclosed in copending U.S. Application No. 101101,548, published September 19, 2002 as US
200210133168 Al (Inventors: Gregory T. Smedley, Irvine, Caiifomia, Ntorteza Gharib, Pasadena, Caiifornia, Hosheng Tu, Newport Beach. California; Attorney Docket No.:
GLAUKO.012A), fled ivtarch 18, :002, cntitlCd APPLICATOR AND METHODS FOR PLACING A TRIBECULAR
SHUNT FOR GL:IUCOMA 'TREATMENT.

The stent has an inlet section and an outlet section. The defivery apparatus includes a handpieca, an e"ate tip, a holder and an actuator. The handpiece has a distal end and a proximat end: The ebngate tip is connected to the distal end of the handpiece. The elongate tip has a distal pordort and is conflgured to be piaced through a comeat incision and into an antedor chamber of the eye.
The holder is attached to tht distal portion of the elongate tip. The holder is configured to hold and release the inlet section of the trabecular stent. The actuator is on the handpiece and actuates the holder to release the inlet sectian of the trabecular stent from the holder. When the trabecular stent is deployed from the delivery apparatus into the eye, the outM section is positbned in substantiaUy opposite directions inside Schlemm's cana! In one embodiment, a deployment mechanism within the delivery apparatus inciudes a push-puY type plunger:
In some embodiments, the holder comprises a clamp. In some embodiments, the apparaw further comprises a spring within the handpiece that is conftgured to be loaded when the stent is being heid by the holder, the spring being at least partiaAy unloaded upon actuating the actuator, aUowing for release of the stent from the holder.
In various embodiments, the clamp compnses a plurality of claws configured to exert a ctamping force onto the inlet section of the stent. The holder may also comprise a plurality of 8anges.
In some embodiments, the distal porton of the elongate tip is made of a flexible materiai. This can be a flexible wire. The distal portion can have aletlection range, preferably of about 45 degrees from `te ',ong axis of the handpiece.
10 The delivery apparatus can further comprise an inigation port in the elongate tip.
Some aspects include a method of placing a trabecular stent through a trabecular meshwork of an eye, the stent having an inlet section and an outlet section, inctuding advancing a delivery apparatus holding ,he trabecular stent through an anterior chamber of the eye and into the trabecular meshwork, placing paR of ;ne stent through the trabecular meshwork and into a Schtemm's canal of the eye; and releasing the Stent 'rom the delivery apparatus.

In various embodiments, the method includes using a delivery apparatus that comprises a handpiece having a distal end and a proximal end; an elongate tip connected to the distal end of the handpiece, the elongate tip having a distai portion and being configured to be placed through a comeal incision and into an anterior chamber of the eye; a holder attached to the distal portion of the elongate 6p, the holder configured to hold and release the inlet section of the trabecular stent; and an actuator on the handpiece that actuates the holder to release the inlet section of the trabecular stent from the holder.
In one aspect, the trabecular stent is removably attached to a delivery apparatus (also known as "appticator"). When the trabecular stent is deployed from the delivery apparatus into the eye, the outlet section is positioned in substantially opposite directions inside Schlemm's canal. In one embodiment, a deployment mechanism within the delivery apparatus includes a push-pull type plunger. In some embodiments, the delivery appticator may be a guidewire, an expandable basket, an inffatabie bafloon, or the like.
Other Emb ments ScrewtBarb Anchored Stent+
FIGS. 32 and 33 illustrate a glaucoma stent device 30f having features and advantages in accordance Wth one embodiment. This embodiment of the trabecular stent 30f includes a barbed or threaded screw-like extension or pin 126 with barbs 128 for anchoring. The barbed pin 126 extends from a distal or base portion 130 of the stent 301.
in use, the stent 30f (FIG. 32) is advanced thmugh the trabeculac meshwork 21 and acro.Ss.
2Q Schlemm's canal 22. The barbed (or threaded) extension 126 penetrates into the back wafl 92 of Schlemm's canal 22 up to the shoulder or base 130 that then rests on the back wa1192 of the canal 22. The combination of a shoulder 130 and a barbed pin 126 of a particutar length timits the penetration depth of the barbed pin 126 to a predeterrnined or presetected distance. In one embodiment, the length of the pin126 is about 0.5 mm or less. Advantageously, this barbed configuration provides a secure anchoring of the stent 30f: As discussed above, correct orientation of the stent 30f is ensured by appropriate fiducial marks, indicia or the like and by positioning of the stent in a preloaded applicator.
Referring to FIG. 32, the aqueous flows from the anterior chamber 20, through the lumen 42f, then out through two side-ports 56f to be directed in both directions along Schlemm's canal 22. Altematively, flow could be directed in only one direction through a single side-port 56f. In other embodiments, more then two outlet ports 56f, for example, six to eight ports (like a pin wheel configuration), may be efficaciously used, as needed or desired.
Stiil refemng to FIG. 32, in one embodiment, the stent 30f is inserted through a previously made incision in the trabecular meshwork 21. In other embodiments, the stent 30f may be combined with any of the blade configurations taught or suggested herein to provide self-trephining capability. In these cases, the incision through the trabecular meshwork 21 is made by the self=trephining stent device which has a blade at its base or proximate to the base.
Deeply Threaded Stent:
FIG. 34 illustrates a glaucoma stent device 30g having features and advantages in accordance with one embodiment. The stent 30g has a head or seat 38g and a shank or main body portion 40g with a base or distal end 132. This embodiment of the trabecular stent 30g includes a deep thread 134 (with threads 136) on the main body 40g of the stent 30g below the head 38g. The threads may or may not extend all the way to the base 132.
In use, the stent 30g (FIG. 34) is advanced through the meshwork 21 through a rotating motion, as with a conventional screw. Advantageously, the deep threads 136 provide retention and stabilization of the stent 30g in the trabecular meshwork 21.
Refering to FIG. 34, the aqueous flows from the anterior chamber 20, through the lumen 42g, then out through two side-ports 56g to be directed in both directions along Schlemm's canal 22. Alternathrely, flow could be directed in only one direction through a single side-port 56g. In other embodiments, more then two outiet ports 56g may be efficaciously used, as needed or desired.
One suitable apphcator or delivery apparatus for this stent 30g (FIG. 34) includes a preset rotation, for exampte, via a wound torsion spring or the like. The rotation is initiated by a release trigger on the applicator. A final twist of the applicator by the surgeon and observatton of suitable fiducial marks, indicia or the like ensure proper alignment of the skie ports 56g with Schlemm's canal 22.
Referring to FIG. 34, in one embodiment, the stert 30g is inserted through a previously mads incision in the trabecular meshwork 21. In other embodiments, the stent 30g may be combined with any of the blade configurations taught or suggested herein to provide self-trephining capabiiity, In these cases, the incision through the trabecular meshwork 21 is made by the seif-trephining stent device which has a blade at its base or proximate to the base.
Rivet Style Stent:
FIG. 35 illustrates a glaucoma stent device 30h having features and advantages in accordance with one embodiment. The stent has a base or distal end 138. This embodiment of the trabecular stent 30h has a pair of flexible ribs 140. In the unused state, the ribs are initially generally straight (that is, extend in the general direction of arrow 142).
Referring to FIG. 35, upon insertion of the stent 30h through the trabecular meshwork 21, the ends 144 of respective ribs 140 of the stent 30h come to rest on the back wall 92 of Schlemm's canal 22. Further advancement of the stent 30h causes the ribs 140 to deform to the bent shape as shown in the drawing of FIG. 35. The ribs 140 are designed to first buckle near the base 138 of the stent 30h. Then the buckling point moves up the ribs 140 as the shank part 40h of the stent 30h is further advanced through the trabecular meshwork 21. - 24 -The lumen 42h (FIG. 35) in the stent 30h is a simple straight hole. The aqueous flows from the anterior chamber 20, through the lumen 42h, then out around the ribs 140 to the collector channels further along Schlemm's canal 22 in either direction.
Referring to FIG. 35, in one embodiment, the stent 30h is inserted through a previously made 5. incision in the trabecular meshwork 21. In other embodiments, the stent 30h may be combined with any of the blade configurations taught or suggested herein to provide self-trephining capability. In these cases, the incision through the trabecular meshwork 21 is made by the self-trephining stent device which has a blade at its base or proximate to the base.
Grommet Style Stent:
FIG. 36 illustrates a glaucoma stent device 301 having features and advantages in accordance with one embodiment. This embodiment of the trabecular stent 301 includes a head or seat 381, a tapered base portion 146 and an intemiediate narrower waist portion or shank 401.
In use, the stent 301 (FIG. 36) is advanced through the trabecular meshwork 21 and the base 146 Is pushed into Schlemm's canal 22. The stent 301 is pushed slightly further, if necessary, untii the meshwork 21 stretched by the tapered base 146 relaxes back and then contracts to engage the smaller diameter portion waist 401 of the stent 30i. Advantageously, the combination of the larger diameter head or seat 38i and base 146 of the stent 301 constrains undesirable stent movement. As discussed above, correct orientation of the stent 30i is ensured by appropriate fiducial marks, indicia or the like and by positieoning of the stent in a preloaded applicatoF.
Referring to FIG. 36, the aqueous flows from the anterior chamber 20, through the lumen 42t; then=
out through two side-ports 561 to be directed in both directions along Schlemm's canat 22. Altematively, flow could be directed In only one direction through a single side-port 561. In other embodiments, more then two outlet ports 561 may be efficaciously used, as needed or desired.
Still referring to FIG. 36, in one embodiment, the stent 301 is inserted through a previously made incision in the trabecular meshwork 21. In other embodiments, the stent 301 may be combined with any of the blade configurations taught or suggested herein to provide self-trephining capability. In these cases, the incision through the trabecular meshwork 21 is made by the self-trephining stent device which has a blade at its base or proximate to the base.
Blointeractive Stent:
FIG. 37 illustrates a glaucoma stent device 30j having features and advantages in accordance with one embodiment. This embodiment of the trabecular stent 30j utilizes a region of biointeractive material 148 that provides a site for the trabecular meshwork 21 to firmly grip the stent 30j by ingrowth of the tissue into the biointeractive material 148. As shown in FIG. 37, preferably the biointeractive layer 148 is applied to those surfaces of the stent 30j which would abut against or come in contact with the trabecular meshwork 21.

In one embodiment, the biointeractive layer 148 (FIG. 37) may be a region of enhanced porosity with a growth promoting chemical. In one embodiment, a type of bio-glue 150 that dissolves over time is used to hold the stent secure during the time between insertion and sufficient ingrowth for stabilization. As discussed above, correct orientation of the stent 30j is ensured by appropriate fiducial marks, indicia or the like and by positioning of the stent in a preloaded applicator.
Refemng to FIG. 37, the aqueous flows from the anterior chamber 20, through the lumen 42j, then out through two side-ports 56j to be directed in both directions along Schlemm's canal 22. Aftematively, flow could be directed in only one direction through a single side-port 56j. In other embodiments, more then two outlet ports 56j may be efficaciously used, as needed or desired.
Stilt referring to FIG. 37, in one embodiment, the stent 30j is inserted through a previously made incision in the trabecular meshwork 21. In other embodiments, the stent 30j may be combined with any of the blade configurations taught or suggested herein to provide self-trephining capability. In thess cases, the incision through the trabecular meshwork 21 is made by the setf-trephining stent device which has a blade at its base or paoximate to the base.
Glued or Welded Stent:
FIG. 38 i8ustrates a glaucoma stent device 30k having features and advantages in accordance with one embodiment. This embodiment of the trabecular stent 30k is secured in place by using a permanent (non-dissohring) bio-glue 152 or a"welding' process (e.g. heat) to form a weld 152. The stent 30k has a head or seat 38k and a lower surface 46k.
20s The stent 30k is advanced through the trabecular meshwork 21 untii the head or seat 38k comes to rest on the trabecular meshwork 21, that is, the head lower surface 46k abuts against the trabecular meshwork 21, and the glue or weld. 152 is applied or formed therebetween, as shown in FIG. 38. As discussed above, correct orientation of the stent 30k is ensured by appropriate fiducial marks, indicia or the like and by positioning of the stent in a preloaded applicator.
Referring to FIG. 38, the aqueous flows from the anterior chamber 20, through the lumen 42k, then out through two side-ports 56k to be directed in both directions along Schlemm's canal 22. Altematively, flow could be directed in only one direction through a single side-port 56k. In other embodiments, more then two outlet ports 56k may be efficaciously used, as needed or desired.
Still referring to FIG. 38, in one embodiment, the stent 30k is inserted through a previously made incision in the trabecular meshwork 21. In other embodiments, the stent 30k may be combined with any of the blade configurations taught or suggested herein to provide self trephining capability. In these cases, the incision through the trabecular meshwork 21 is made by the self-trephining stent device which has a blade at its base or proximate to the base.

Hydrophiiic Latching Stent:
FIG. 39 illustrates a glaucoma stent device 30m having features and advantages in accordance with one embodiment. This embodiment of the trabecular stent 30m is fabricated from a hydrophific materiai that expands with absorption of water. Desirably, this would enable the device 30m to be inserted through a smaller incision in the trabecular meshwork 21. The subsequent expansion (illustrated by the smaller arrows 154) of the stent 30m would advantageously enable it to latch in place in the trabecular meshwork 21. As discussed above, con-ect orientation of the stent 30m is ensured by appropriate fiducial marks, indicia or the like and by positioning of the stent in a preloaded applicator.
Referring to FIG. 39, the aqueous flows from the anterior chamber 20, through the lumen 42m, then out through two side-ports 56m to be directed in both directions along Schtemm's canal 22. Aitematively, flow could be directed in only one direction through a single side-poit 56m. In other embodiments, more then two outlet ports 56m may be efficaciously used, as needed or desired.
Stiii referring to FIG. 39, in one embodiment, the stent 30m is inserted through a previously made incision in the trabecular meshwork 21. In other embodiments, the stent 30m may be combined with any of the blade conflgurations taught or suggested herein to provide self-trephining capability. In these cases, the incision through the trabecular meshwork 21 is made by the self-trephining stent device which has a blade at its base or proximate to the base.
Photodynamic Stent:
FIG. 40 iiiustnates a glaucoma stent device 30n having features and advantages in accordance with one embodiment. This embodiment of the trabecular stent 30n is fabricated from a photodynamic material that expaWs on exposure to right.
It is commonly known that there is a diumai variation in the aqueous humor producti~on by the eye ---it is higher during the day than it is at night. The lumen 42n of the stent 30n responds to light entering the comea during the day by expanding and allowing higher ftow of aqueous through the lumen 42n and into Schlemm's canal 22. This expansion is generally indicated by the smaller arrows 156 (FIG. 40) which show the lumen 42n (and ports) expanding or opening in response to light stimuius.
(The light or radiation energy E
is generally given by E= hv, where h is Planck's constant and v is the frequency of the light provided.) At night, in darkness, the lumen diameter decreases and reduces the flow allowed through the lumen 42n. In one embodiment, an excitation wavelength that is different from that commonly encountered is provided on an as-needed basis to provide higher flow of aqueous to Schlemm's canal 22.
This photodynamic implementation is shown in FIG. 40 for the self-latching styie of stent 30n, but can be efficaciously used with any of the other stent embodiments, as needed or desired. As discussed above, correct orientation of the stent 30n is ensured by appropriate fiducial marks, indicia or the like and by positioning of the stent in a preloaded applicator.

Referring to FIG. 40, the aqueous flows from the anterior chamber 20, through the lumen 42n, then out through two side-ports 56n to be directed in both directions along Schlemm's canal 22. Aitemaatively, flow could be directed in only one direction through a single side-port 56n. In other embodiments, more then two outlet ports 56n may be efficaciously used, as needed or desired.
Stiii referring to FIG. 40, in one embodiment, the stent 30n is inserted through a previously made incision in the trabecular meshwork 21. In other embodiments, the stent 30n may be combined vrith any of the blade configurations taught or suggested herein to provide self-trephining capability. In these cases, the incision through the trabecular meshwork 21 is made by the self trephining stent device which has a blade at its base or proximate to the base.
Collector Channel Alignment Stent:
FIG. 41 illustrates a glaucoma stent device 30p having features and advantages in accordance with one embodiment. This figure depicts an embodiment of a stent 30p that directs aqueous fr= the anterior chamber 20 directly into a collector channe129 which empties into aqueous veins. The stent 30p has a base or distal end 160.
In the illustrated embodiment of FIG. 41, a removabte alignment pin 158 is utiiized to align the stent lumen 42p with the collector channel 29. In use, the pin 158 extends through the stent iunien 42p and protrudes through the base 160 and extends into the collector channel 29 to center andlor align the stent 30p over the co0ector channel 29. The stent 30p is then pressed firmly against the back wat 92 of Schlemm's - canal 22. A permanent bio-gfue 162 is used between the stent base and the back waU 92 of Schiemm's canal 22 to seat and securely hold the stent 30p in place. Once positioned, the pin 158 is withdrawn from the lumen 42p to aNow the aqueous to flow directly from the anterior chamber 20 into the collector duct 29. The collector ducts are nominally 20 to 100 micrometers ( m) in diameter and are visualized with a suitabie microscopy method (such as uitrasound biomicroscopy (UBM)) or laser imaging to provide guidance for piacement of the stent 30p.
Referring to FIG. 41, in one embodiment, the stent 30p is inserted through a previously made incision in the trabecular meshwork 21. In other embodiments, the stent 30p may be combined with any of the blade configurations taught or suggested herein to provide self-trephining capability. In these cases, the incision through the trabecular meshwork 21 is made by the self-trephining stent device which has a blade at its base or proximate to the base.
Barbed Stent (Anterior Chamber to Collector Channel):
FIG. 42 illustrates a glaucoma stent device 30q having features and advantages in accordance with one embodiment. This figure depicts an embodiment of a stent 30q that directs aqueous from the anterior chamber 20 dinectiy into a collector channel 29 which empties into aqueous veins. The stent 30q has a base or distal end 166 and the channe129 has wali(s)164.

In the illustrated embodiment of FIG. 42, a barbed, small-diameter extension or pin 168 on the stent base 166 is guided into the collector channel 29 and anchors on the wall(s) 164 of the channel 29. The pin 168 has barbs 170 which advantageously provide anchoring of the stent 30q. The collector ducts 29 are nominally 20 to 100 micrometers ( m) in diameter and are visualized with a suitable microscopy method (such as ultrasound biomicroscopy (UBM)) or laser imaging to provide guidance for placement of the stent.
Refening to FIG. 42, in one embodiment, the stent 30q is inserted through a previously made incision in the trabecular meshwork 21. In other embodiments, the stent 30q may be combined with any of the blade configurations taught or suggested herein to provide self-trephining capabiiity. In these cases, the incision through the trabecular meshwork 21 is made by the self-trephining stent device which has a blade at its base or proximate to the base.
Valved Tube Stent (Anterior Chamber to Chorold):
FIG. 43 illustrates a valved tube stent device 30r having features and advantages in accordance with one embodiment. This is an embodiment of a stent 30r that pnovides a channel for fiow between the anterior chamber 20 and the highly vascular choroid 17. Clinically, the choroid 17 can be at pressures lower than those desired for the eye 10. Therefore, this stent 30r includes a valve with an opening pressure equal to the desired pressure difference between the choroid 17 and the anterior chamber 10 or a constriction that provide the desired pressure drop.
Osmotic Membrane (Anterior Chamber to Choroid):
FIG. 44 illustrates a osmotic membrane device 30s having features and advantages in accondance with one embodiment This embodiment provides a channei. for flow between the anterior chamber 20 ant the highly vascular choroid 17. The osmotic membrane 30s is used to replace a portion of the endothelial layer of the choroid 17. Since the choroid 17 is highly vascular with blood vessels, the concentration of water on the choroid side is lower than in the anterior chamber 20 of the eye 10.
Therefore, the osmotic gradient drives water from the anterior chamber 20 into the choroid 17.
Ciinically, the choroid 17 (FIG. 44) can be at pressures lower than those desired for the eye 10.
Therefore, desirably, both osmotic pressure and the physical pressure gradient are in favor of fbw into the choroid 17. Flow controi is provided by proper sizing of the area of the membrane, - the larger the membrane area is the larger the flow rate will be. This advantageously enables tailoring to tune the flow to the desired physiological rates.
Ab Extemo Insertion of Stent via Small Puncture:
FIG. 45 illustrates the implantation of a stent 30t using an ab extemo procedure having features and advantages in accordance with one embodiment. In the ab extemo procedure of FIG. 45, the stent 30t is inserted into Schlemm's canal 21 with the aid of an applicator or delivery apparatus 100c that creates a small puncture into the eye 10 from outside.

Referring to FIG. 45, the stent 30t is housed in the applicator 100c, and pushed out of the applicator 100c once the applicator tip is in position within the trabecular meshwork 21.
Since the tissue surrounding the trabecular meshwork 21 is optically opaque, an imaging technique, such as ultrasound biomicroscopy (UBM) or a laser imaging technique, is utilized. The imaging provides guidance for the insertion of the applicator tip and the deployment of the stent 30t. This technique can be used with a large variety of stent embodiments with slight modifications since the trabecular meshwork 21 is punctured from the scieral side rather than the anterior chamber side in the ab extemo insertion.
FIG. 46 a glaucoma stent device 30u having features and advantages in accordance with a modified embodiment. This grommet-style stent 30u for ab extemo insention is a modification of the embodiment of FIG, 36. In the embodiment of FIG. 46, the upper part or head 38u is tapered while the lower part or base 172 is flat, as opposed to the embodiment of FIG. 36. The stent 30u is inserted from the outside of the eye 10 through a puncture in the sciera. Many of the other embodiments of stents taught or suggested herein can be modified for similar implantation.
This ultra microscopic device 30u (FIG. 46) can be used with (1) a targeting Lasik-type laser, or with (2) contact on eyes or with (3) combined ultrasourd microscope or (4) other device insertor handpiece.
Targeted Drug Delivery to the Trabecular Meshwork:
FIG. 47 illustrates a targeted drug delivery implant 30v having features and advantages in accordance with one embodiment. This drawing is a depiction of a targeted drug delivery concepE. The slow release implant 30v is implanted within the trabecular meshwork 21.
A drug that is designed to target the trabecular meshwork 21 to increase its porosity, or improve ihe active transport across the endothelial layer of Schlemm's canal 22 can be stored in this smaN implant 30v (FIG. 47). Advantageously, slow release of the drug promotes the desired physiology at minimai dosage levels since the drug is released into the very structure that it is designed to modify.
While the components and techniques of the invention have been described with a certain degree of panticularity, it is manifest that many changes may be made in the specific designs, constructions and methodology herein above described without departing from the spirit and scope of this disclosure. It should be understood that the invention is not limited to the embodiments set forth herein for purposes of exemplification, but is to be defined only by a fair reading of the appended claims, including the full range of equivalency to which each element thereof is entitled.

Claims (25)

1. A system for treating an ocular disorder, comprising:
an implant having an inlet portion and an outlet portion, a lumen extending between the inlet portion and the outlet portion and communicating with inlet and outlet ports, the implant sized so that in use aqueous humor flows from an anterior chamber of an eye into the lumen through the inlet port and then through the outlet port and into a uveal scleral outflow path of the eye; and a delivery device configured to advance the implant from within the anterior chamber, with the outlet portion leading the inlet portion, to a location where the outlet port communicates with the uveal scleral outflow path and the inlet port communicates with the anterior chamber.
2. The system of claim 1, wherein the implant is sized so that in use it contacts a choroid of the eye.
3. The system of claims 1 or 2, wherein the outlet portion has a head portion, and wherein the outlet port is located along a surface of the head portion.
4. The system of claim 3, wherein said surface is generally curvilinear.
5. The system of claim 3, wherein the head portion has a bulbous shape.
6. The system of any one of claims 1 to 5, wherein the inlet portion comprises a seat to stabilize the implant within the eye.
7. The system of any one of claims 1 to 6, wherein a shank extends between said inlet portion and said outlet portion.
8. The system of any one of claims 1 to 7, wherein the implant further comprises a cutting member.
9. The system of claim 8, wherein the cutting member has a cutting tip configured to make an incision in eye tissue for receiving at least a portion of the implant.
10. The system of any one of claims 1 to 9, wherein the implant further comprises at least one anchor to anchor the implant within the eye.
11. The system of any one of claims 1 to 10, wherein the implant further comprises a flow controller to regulate the flow of aqueous humor through the implant.
12. The system of claim 11, wherein the flow controller comprises a valve.
13. The system of claim 11, wherein the flow controller comprises a constriction within the lumen of the implant.
14. The system of any one of claims 1 to 13, wherein the implant comprises a therapeutic agent.
15. The system of any one of claims 1 to 14, wherein the delivery device comprises a distal portion configured to hold the implant, and wherein the distal portion is non-linear and is configured to position the implant at said location in the eye.
16. The system of claim 15, wherein the distal portion of the delivery device is configured to extend within the anterior chamber and is angled to position the implant at said location in the eye.
17. The system of any one of claims 1 to 14, wherein the delivery device comprises a proximal portion and a distal portion configured to hold the implant, and wherein the proximal portion is movably attached to the distal portion.
18. The system of claim 17, wherein the proximal portion is attached to the distal portion at a movable joint.
19. The system of any one of claims 1 to 14, wherein the delivery device comprises a proximal portion and a distal portion configured to hold the implant, and wherein an angle formed between the proximal portion and the distal portion can change.
20. The system of any one of claims 1 to 14, wherein the delivery device comprises a handpiece and an elongate tip connected to a distal end of the handpiece, and wherein the elongate tip comprises a distal portion configured to hold the implant.
21. The system of claim 20, wherein the delivery device further comprises a holder attached to the distal portion of the elongate tip, and wherein the holder is configured to hold and release at least part of the implant.
22. The system of claim 21, wherein the delivery device further comprises an actuator on the handpiece, and wherein the actuator is configured to actuate the holder to release the implant from the holder.
23. The system of any one of claims 20 to 22, wherein the distal portion of the elongate tip is made of a flexible material.
24. The system of any one of claims 20 to 23, wherein the distal portion of the elongate tip has a deflection range.
25. The system of any one of claims 1 to 24, wherein the implant comprises a body made of a flexible material.
CA2683224A 2001-04-07 2002-04-08 System and methods thereof for treatment of ocular disorders Expired - Lifetime CA2683224C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US28197301P 2001-04-07 2001-04-07
US60/281,973 2001-04-07
CA2442652A CA2442652C (en) 2001-04-07 2002-04-08 Glaucoma stent and methods thereof for glaucoma treatment

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA2442652A Division CA2442652C (en) 2001-04-07 2002-04-08 Glaucoma stent and methods thereof for glaucoma treatment

Publications (2)

Publication Number Publication Date
CA2683224A1 true CA2683224A1 (en) 2002-10-17
CA2683224C CA2683224C (en) 2014-12-02

Family

ID=23079551

Family Applications (2)

Application Number Title Priority Date Filing Date
CA2442652A Expired - Lifetime CA2442652C (en) 2001-04-07 2002-04-08 Glaucoma stent and methods thereof for glaucoma treatment
CA2683224A Expired - Lifetime CA2683224C (en) 2001-04-07 2002-04-08 System and methods thereof for treatment of ocular disorders

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CA2442652A Expired - Lifetime CA2442652C (en) 2001-04-07 2002-04-08 Glaucoma stent and methods thereof for glaucoma treatment

Country Status (9)

Country Link
US (11) US7135009B2 (en)
EP (4) EP2982354A1 (en)
JP (4) JP4264704B2 (en)
AT (1) ATE390106T1 (en)
AU (3) AU2002258754B2 (en)
CA (2) CA2442652C (en)
DE (1) DE60225815T2 (en)
ES (1) ES2304438T3 (en)
WO (1) WO2002080811A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11116625B2 (en) 2017-09-28 2021-09-14 Glaukos Corporation Apparatus and method for controlling placement of intraocular implants

Families Citing this family (210)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8313454B2 (en) 1997-11-20 2012-11-20 Optonol Ltd. Fluid drainage device, delivery device, and associated methods of use and manufacture
BR0010055A (en) 1999-04-26 2002-04-09 Gmp Vision Solutions Inc Bypass device and use thereof
US7229469B1 (en) 1999-10-02 2007-06-12 Quantumcor, Inc. Methods for treating and repairing mitral valve annulus
US7135009B2 (en) 2001-04-07 2006-11-14 Glaukos Corporation Glaucoma stent and methods thereof for glaucoma treatment
US7867186B2 (en) * 2002-04-08 2011-01-11 Glaukos Corporation Devices and methods for treatment of ocular disorders
US7708711B2 (en) 2000-04-14 2010-05-04 Glaukos Corporation Ocular implant with therapeutic agents and methods thereof
US6638239B1 (en) 2000-04-14 2003-10-28 Glaukos Corporation Apparatus and method for treating glaucoma
US9603741B2 (en) 2000-05-19 2017-03-28 Michael S. Berlin Delivery system and method of use for the eye
US6962573B1 (en) 2000-10-18 2005-11-08 Wilcox Michael J C-shaped cross section tubular ophthalmic implant for reduction of intraocular pressure in glaucomatous eyes and method of use
US6881198B2 (en) * 2001-01-09 2005-04-19 J. David Brown Glaucoma treatment device and method
US7488303B1 (en) 2002-09-21 2009-02-10 Glaukos Corporation Ocular implant with anchor and multiple openings
US7431710B2 (en) 2002-04-08 2008-10-07 Glaukos Corporation Ocular implants with anchors and methods thereof
US7678065B2 (en) 2001-05-02 2010-03-16 Glaukos Corporation Implant with intraocular pressure sensor for glaucoma treatment
AU2002305400A1 (en) 2001-05-03 2002-11-18 Glaukos Corporation Medical device and methods of use for glaucoma treatment
US7331984B2 (en) 2001-08-28 2008-02-19 Glaukos Corporation Glaucoma stent for treating glaucoma and methods of use
US8491549B2 (en) 2001-11-21 2013-07-23 Iscience Interventional Corporation Ophthalmic microsurgical system
WO2003073968A2 (en) 2002-02-28 2003-09-12 Gmp Vision Solutions, Inc. Device and method for monitoring aqueous flow within the eye
US7186232B1 (en) 2002-03-07 2007-03-06 Glaukoa Corporation Fluid infusion methods for glaucoma treatment
US7951155B2 (en) 2002-03-15 2011-05-31 Glaukos Corporation Combined treatment for cataract and glaucoma treatment
EP1487388A2 (en) * 2002-03-22 2004-12-22 Iscience Corporation Ophthalmic microfiducial device and method for use
US9301875B2 (en) 2002-04-08 2016-04-05 Glaukos Corporation Ocular disorder treatment implants with multiple opening
US7192412B1 (en) * 2002-09-14 2007-03-20 Glaukos Corporation Targeted stent placement and multi-stent therapy
US7160264B2 (en) * 2002-12-19 2007-01-09 Medtronic-Xomed, Inc. Article and method for ocular aqueous drainage
US8012115B2 (en) * 2003-02-18 2011-09-06 S.K. Pharmaceuticals, Inc. Optic nerve implants
RU2361552C2 (en) * 2003-02-18 2009-07-20 Хампар КАРАГЕОЗЯН Ways and devices for drainage of liquids and ophthalmotonus pressure dropping
US20040193095A1 (en) * 2003-03-29 2004-09-30 Shadduck John H. Implants for treating ocular hypertension, methods of use and methods of fabrication
US20040225250A1 (en) 2003-05-05 2004-11-11 Michael Yablonski Internal shunt and method for treating glaucoma
US7381180B2 (en) * 2003-10-31 2008-06-03 Medtronic, Inc. Implantable devices and methods for treating fecal incontinence
US7585271B2 (en) * 2003-11-01 2009-09-08 Thd Spa Implantable devices and methods for treating urinary incontinence
US7291125B2 (en) 2003-11-14 2007-11-06 Transcend Medical, Inc. Ocular pressure regulation
US7544176B2 (en) 2005-06-21 2009-06-09 Becton, Dickinson And Company Glaucoma implant having MEMS flow module with flexing diaphragm for pressure regulation
US7364564B2 (en) 2004-03-02 2008-04-29 Becton, Dickinson And Company Implant having MEMS flow module with movable, flow-controlling baffle
US20050194303A1 (en) * 2004-03-02 2005-09-08 Sniegowski Jeffry J. MEMS flow module with filtration and pressure regulation capabilities
US7384550B2 (en) 2004-02-24 2008-06-10 Becton, Dickinson And Company Glaucoma implant having MEMS filter module
US20050232972A1 (en) 2004-04-15 2005-10-20 Steven Odrich Drug delivery via punctal plug
KR20070036044A (en) * 2004-04-29 2007-04-02 아이싸이언스 인터벤셔날 코포레이션 Apparatus and method for ocular treatment
EP1786489A2 (en) * 2004-05-27 2007-05-23 Clarity Corporation Glaucoma shunt
US20050283108A1 (en) * 2004-06-10 2005-12-22 Savage James A Apparatus and method for non-pharmacological treatment of glaucoma and lowering intraocular pressure
JP2008504938A (en) 2004-07-02 2008-02-21 レイザー,エリオット Treatment medium delivery apparatus and method for delivering treatment medium to eyes using the delivery apparatus
CA2592459C (en) * 2004-12-16 2017-08-22 Iscience Interventional Corporation Ophthalmic implant for treatment of glaucoma
WO2006080191A1 (en) * 2005-01-26 2006-08-03 Hoya Corporation Intraocular lens insertion device
US9186274B2 (en) * 2005-02-23 2015-11-17 Camras Vision Inc. Method and apparatus for reducing intraocular pressure
US7641627B2 (en) * 2005-02-23 2010-01-05 Camras Carl B Method and apparatus for reducing intraocular pressure
JP4836046B2 (en) 2005-02-24 2011-12-14 Hoya株式会社 Intraocular lens insertion device
US8574239B2 (en) * 2005-09-28 2013-11-05 Hoya Corporation Intraocular lens insertion device
US20070106200A1 (en) * 2005-11-08 2007-05-10 Brian Levy Intraocular shunt device and method
US10219942B1 (en) * 2005-12-03 2019-03-05 S. Gregory Smith Eye implant devices and method and device for implanting such devices for treatment of glaucoma
JP4877643B2 (en) 2005-12-08 2012-02-15 Hoya株式会社 Intraocular lens insertion device
ES2762239T3 (en) 2006-01-17 2020-05-22 Alcon Inc Glaucoma treatment device
US9084662B2 (en) 2006-01-17 2015-07-21 Transcend Medical, Inc. Drug delivery treatment device
BRPI0709672B8 (en) 2006-03-31 2021-06-22 3088922 Inc ocular implant insertable into an ocular lumen and method of delivering a therapeutic agent to an eye
US20070293807A1 (en) * 2006-05-01 2007-12-20 Lynch Mary G Dual drainage pathway shunt device and method for treating glaucoma
AU2007267695A1 (en) * 2006-05-23 2007-12-06 Entrigue Surgical, Inc. Sinus tube
US7909789B2 (en) * 2006-06-26 2011-03-22 Sight Sciences, Inc. Intraocular implants and methods and kits therefor
US8852256B2 (en) 2010-11-15 2014-10-07 Aquesys, Inc. Methods for intraocular shunt placement
US8852137B2 (en) 2010-11-15 2014-10-07 Aquesys, Inc. Methods for implanting a soft gel shunt in the suprachoroidal space
US8974511B2 (en) 2010-11-15 2015-03-10 Aquesys, Inc. Methods for treating closed angle glaucoma
US8721702B2 (en) * 2010-11-15 2014-05-13 Aquesys, Inc. Intraocular shunt deployment devices
US20120123316A1 (en) 2010-11-15 2012-05-17 Aquesys, Inc. Intraocular shunts for placement in the intra-tenon's space
US9095411B2 (en) 2010-11-15 2015-08-04 Aquesys, Inc. Devices for deploying intraocular shunts
US8828070B2 (en) 2010-11-15 2014-09-09 Aquesys, Inc. Devices for deploying intraocular shunts
US8308701B2 (en) 2010-11-15 2012-11-13 Aquesys, Inc. Methods for deploying intraocular shunts
US8801766B2 (en) 2010-11-15 2014-08-12 Aquesys, Inc. Devices for deploying intraocular shunts
US20080108933A1 (en) * 2006-06-30 2008-05-08 Dao-Yi Yu Methods, Systems and Apparatus for Relieving Pressure in an Organ
US8663303B2 (en) 2010-11-15 2014-03-04 Aquesys, Inc. Methods for deploying an intraocular shunt from a deployment device and into an eye
US8758290B2 (en) 2010-11-15 2014-06-24 Aquesys, Inc. Devices and methods for implanting a shunt in the suprachoroidal space
US10085884B2 (en) 2006-06-30 2018-10-02 Aquesys, Inc. Intraocular devices
US8187266B2 (en) 2006-09-29 2012-05-29 Quantumcor, Inc. Surgical probe and methods for targeted treatment of heart structures
JP5748407B2 (en) * 2006-11-10 2015-07-15 グローコス コーポレーション Uveal sclera shunt
WO2008068911A1 (en) * 2006-12-01 2008-06-12 Yugen Kaisha Conan Instillation device for microscopic ophthalmic surgery
EP2161004B1 (en) 2007-05-30 2017-12-27 Hoya Corporation Intraocular lens inserting tool
JP5236638B2 (en) 2007-05-30 2013-07-17 Hoya株式会社 Intraocular lens insertion device
WO2008154502A1 (en) * 2007-06-07 2008-12-18 Yale University Uveoscleral drainage device
JP5086713B2 (en) 2007-07-11 2012-11-28 Hoya株式会社 Intraocular lens insertion device
EP2173289A4 (en) * 2007-07-17 2010-11-24 Transcend Medical Inc Ocular implant with hydrogel expansion capabilities
US20090043242A1 (en) * 2007-08-07 2009-02-12 Becton, Dickinson And Company Instruments and methods for implanting corneal implant via extra-and intra-cameral routes
JP5524841B2 (en) 2007-09-07 2014-06-18 キュー エル ティー インク. Lacrimal implant and related methods
EP2205193A2 (en) 2007-09-07 2010-07-14 QLT Plug Delivery, Inc. Lacrimal implant detection
AU2008300013A1 (en) 2007-09-07 2009-03-19 Qlt Inc. Drug cores for sustained release of therapeutic agents
US8734377B2 (en) 2007-09-24 2014-05-27 Ivantis, Inc. Ocular implants with asymmetric flexibility
US20170360609A9 (en) 2007-09-24 2017-12-21 Ivantis, Inc. Methods and devices for increasing aqueous humor outflow
US20090082862A1 (en) 2007-09-24 2009-03-26 Schieber Andrew T Ocular Implant Architectures
US7740604B2 (en) 2007-09-24 2010-06-22 Ivantis, Inc. Ocular implants for placement in schlemm's canal
US8512404B2 (en) 2007-11-20 2013-08-20 Ivantis, Inc. Ocular implant delivery system and method
US8808222B2 (en) 2007-11-20 2014-08-19 Ivantis, Inc. Methods and apparatus for delivering ocular implants into the eye
WO2009096855A1 (en) * 2008-01-28 2009-08-06 Milux Holding Sa Blood clot removal device, system, and method
US8109896B2 (en) * 2008-02-11 2012-02-07 Optonol Ltd. Devices and methods for opening fluid passageways
MX2010008998A (en) * 2008-02-18 2010-11-26 Qlt Plug Delivery Inc Lacrimal implants and related methods.
JP2011513002A (en) 2008-03-05 2011-04-28 イバンティス インコーポレイテッド Method and apparatus for treating glaucoma
CN104623741A (en) 2008-04-30 2015-05-20 马缇医疗股份有限公司 Composite lacrimal insert and related methods
NZ588938A (en) 2008-05-09 2013-03-28 Mati Therapeutics Inc Sustained release delivery of active agents to treat glaucoma and ocular hypertension
US9877973B2 (en) 2008-05-12 2018-01-30 University Of Utah Research Foundation Intraocular drug delivery device and associated methods
US9095404B2 (en) 2008-05-12 2015-08-04 University Of Utah Research Foundation Intraocular drug delivery device and associated methods
CN102026599A (en) 2008-05-12 2011-04-20 犹他大学研究基金会 Intraocular drug delivery device and associated methods
US10064819B2 (en) 2008-05-12 2018-09-04 University Of Utah Research Foundation Intraocular drug delivery device and associated methods
JP5254669B2 (en) 2008-06-05 2013-08-07 Hoya株式会社 Intraocular lens insertion device and cartridge
JP5470753B2 (en) 2008-06-17 2014-04-16 Hoya株式会社 Intraocular lens insertion device
ES2640867T3 (en) 2008-06-25 2017-11-07 Novartis Ag Eye implant with ability to change shape
JP5323420B2 (en) 2008-08-21 2013-10-23 Hoya株式会社 Intraocular lens insertion device
US9125720B2 (en) 2008-10-13 2015-09-08 Alcon Research, Ltd. Capsularhexis device with flexible heating element
US8353856B2 (en) 2008-11-05 2013-01-15 Abbott Medical Optics Inc. Glaucoma drainage shunts and methods of use
CN102238926B (en) 2008-12-05 2015-09-16 伊万提斯公司 For ocular implants being transported to the method and apparatus in eyes
US8137344B2 (en) 2008-12-10 2012-03-20 Alcon Research, Ltd. Flexible, automated capsulorhexis device
JP5413918B2 (en) 2009-01-07 2014-02-12 Hoya株式会社 Intraocular lens insertion device
US8157797B2 (en) 2009-01-12 2012-04-17 Alcon Research, Ltd. Capsularhexis device with retractable bipolar electrodes
EP2548538B1 (en) 2009-01-28 2020-04-01 Alcon Inc. Implantation systems for ocular implants with stiffness qualities
US20100191168A1 (en) 2009-01-29 2010-07-29 Trustees Of Tufts College Endovascular cerebrospinal fluid shunt
FR2941618B1 (en) * 2009-02-04 2011-03-11 Bruno Fayet ASSEMBLY FOR INSERTING A PROBE IN THE LACRYMAL CHANNEL BY PUSHING THE EYE SIDE
AU2010215745A1 (en) 2009-02-23 2011-09-01 Qlt Inc. Lacrimal implants and related methods
AU2010229789B2 (en) * 2009-03-26 2014-11-13 Johnson & Johnson Surgical Vision, Inc. Glaucoma shunts with flow management and improved surgical performance
US10206813B2 (en) 2009-05-18 2019-02-19 Dose Medical Corporation Implants with controlled drug delivery features and methods of using same
EP4289416A3 (en) * 2009-05-18 2024-01-03 Dose Medical Corporation Drug eluting ocular implant
US8814854B2 (en) 2009-06-03 2014-08-26 Alcon Research, Ltd. Capsulotomy repair device and method for capsulotomy repair
AU2010271218B2 (en) * 2009-07-09 2017-02-02 Alcon Inc. Ocular implants and methods for delivering ocular implants into the eye
AU2010271274B2 (en) 2009-07-09 2015-05-21 Alcon Inc. Single operator device for delivering an ocular implant
EP2490621A4 (en) 2009-10-23 2013-04-03 Ivantis Inc Ocular implant system and method
US8771216B2 (en) 2009-11-06 2014-07-08 University Hospitals Of Cleveland Fluid communication device and method of use thereof
EP2512389B1 (en) * 2009-12-16 2015-09-02 Allergan, Inc. Intracameral devices for sustained delivery
US8343106B2 (en) 2009-12-23 2013-01-01 Alcon Research, Ltd. Ophthalmic valved trocar vent
US8529492B2 (en) 2009-12-23 2013-09-10 Trascend Medical, Inc. Drug delivery devices and methods
MX2012006598A (en) 2009-12-23 2012-06-19 Alcon Res Ltd Ophthalmic valved trocar cannula.
US8529622B2 (en) 2010-02-05 2013-09-10 Sight Sciences, Inc. Intraocular implants and related kits and methods
EP2555708B1 (en) 2010-04-08 2015-03-18 Hoya Corporation Ocular implant insertion apparatus
US9241755B2 (en) 2010-05-11 2016-01-26 Alcon Research, Ltd. Capsule polishing device and method for capsule polishing
DE102010029396B4 (en) * 2010-05-27 2012-04-19 Gudrun Brümmer-Schillke Eye implant for regulation of intraocular pressure
US8545430B2 (en) 2010-06-09 2013-10-01 Transcend Medical, Inc. Expandable ocular devices
JP5511530B2 (en) * 2010-06-10 2014-06-04 Hoya株式会社 Intraocular lens insertion device
WO2011163505A1 (en) 2010-06-23 2011-12-29 Ivantis, Inc. Ocular implants deployed in schlemm's canal of the eye
US9149388B2 (en) 2010-09-29 2015-10-06 Alcon Research, Ltd. Attenuated RF power for automated capsulorhexis
US20160256319A1 (en) 2010-11-15 2016-09-08 Aquesys, Inc. Intraocular shunt placement in the suprachoroidal space
US8585629B2 (en) 2010-11-15 2013-11-19 Aquesys, Inc. Systems for deploying intraocular shunts
US8657776B2 (en) 2011-06-14 2014-02-25 Ivantis, Inc. Ocular implants for delivery into the eye
WO2013011511A1 (en) 2011-07-18 2013-01-24 Mor Research Applications Ltd. A device for adjusting the intraocular pressure
US9974685B2 (en) 2011-08-29 2018-05-22 Mati Therapeutics Drug delivery system and methods of treating open angle glaucoma and ocular hypertension
CA2846384C (en) 2011-08-29 2020-12-15 Qlt Inc. Sustained release delivery of active agents to treat glaucoma and ocular hypertension
EP4193907A1 (en) 2011-09-13 2023-06-14 Glaukos Corporation Intraocular physiological sensor
US9808373B2 (en) 2013-06-28 2017-11-07 Aquesys, Inc. Intraocular shunt implantation
US10080682B2 (en) 2011-12-08 2018-09-25 Aquesys, Inc. Intrascleral shunt placement
US8765210B2 (en) 2011-12-08 2014-07-01 Aquesys, Inc. Systems and methods for making gelatin shunts
US8852136B2 (en) 2011-12-08 2014-10-07 Aquesys, Inc. Methods for placing a shunt into the intra-scleral space
US9610195B2 (en) 2013-02-27 2017-04-04 Aquesys, Inc. Intraocular shunt implantation methods and devices
US8663150B2 (en) 2011-12-19 2014-03-04 Ivantis, Inc. Delivering ocular implants into the eye
EP2814555B1 (en) * 2012-02-13 2017-09-27 Iridex Corporation Reduction of intraocular pressure in the eye using a tubular clip
US10213533B2 (en) * 2012-03-05 2019-02-26 Keith A. Walter Medical tools with aspiration tips suitable for cataract surgeries and related methods
EP4302734A3 (en) 2012-03-20 2024-03-20 Sight Sciences, Inc. Ocular delivery systems and methods
CA2868341C (en) 2012-03-26 2021-01-12 Glaukos Corporation System and method for delivering multiple ocular implants
US9358156B2 (en) 2012-04-18 2016-06-07 Invantis, Inc. Ocular implants for delivery into an anterior chamber of the eye
US10085633B2 (en) 2012-04-19 2018-10-02 Novartis Ag Direct visualization system for glaucoma treatment
US9241832B2 (en) 2012-04-24 2016-01-26 Transcend Medical, Inc. Delivery system for ocular implant
US8858491B2 (en) * 2012-05-23 2014-10-14 Alcon Research, Ltd. Pre-biased membrane valve
EP3228286A1 (en) 2012-09-17 2017-10-11 Novartis AG Expanding ocular impant devices
WO2014078288A1 (en) 2012-11-14 2014-05-22 Transcend Medical, Inc. Flow promoting ocular implant
US10617558B2 (en) 2012-11-28 2020-04-14 Ivantis, Inc. Apparatus for delivering ocular implants into an anterior chamber of the eye
US10159600B2 (en) 2013-02-19 2018-12-25 Aquesys, Inc. Adjustable intraocular flow regulation
US9125723B2 (en) 2013-02-19 2015-09-08 Aquesys, Inc. Adjustable glaucoma implant
USD707818S1 (en) 2013-03-05 2014-06-24 Alcon Research Ltd. Capsulorhexis handpiece
US9730638B2 (en) 2013-03-13 2017-08-15 Glaukos Corporation Intraocular physiological sensor
US10517759B2 (en) 2013-03-15 2019-12-31 Glaukos Corporation Glaucoma stent and methods thereof for glaucoma treatment
US9592151B2 (en) 2013-03-15 2017-03-14 Glaukos Corporation Systems and methods for delivering an ocular implant to the suprachoroidal space within an eye
US9987163B2 (en) 2013-04-16 2018-06-05 Novartis Ag Device for dispensing intraocular substances
US20150057583A1 (en) * 2013-08-24 2015-02-26 Alcon Research, Ltd. Trabecular meshwork stimulation device
US9226851B2 (en) 2013-08-24 2016-01-05 Novartis Ag MEMS check valve chip and methods
JP6574780B2 (en) 2013-11-14 2019-09-11 アクエシス, インコーポレイテッド Intraocular shunt inserter
US9044301B1 (en) * 2013-11-25 2015-06-02 Innfocus, Inc. Methods, systems and devices for treating glaucoma
US9737696B2 (en) 2014-01-15 2017-08-22 Tufts Medical Center, Inc. Endovascular cerebrospinal fluid shunt
EP3998100A1 (en) 2014-01-15 2022-05-18 Tufts Medical Center, Inc. Endovascular cerebrospinal fluid shunt system
USD737438S1 (en) 2014-03-04 2015-08-25 Novartis Ag Capsulorhexis handpiece
US20150342875A1 (en) 2014-05-29 2015-12-03 Dose Medical Corporation Implants with controlled drug delivery features and methods of using same
EP4242614A3 (en) 2014-07-01 2023-11-29 Injectsense, Inc. Hermetically sealed implant sensors with vertical stacking architecture
EP3164061A4 (en) 2014-07-01 2018-01-10 Injectsense, Inc. Methods and devices for implantation of intraocular pressure sensors
WO2016011056A1 (en) 2014-07-14 2016-01-21 Ivantis, Inc. Ocular implant delivery system and method
US10201451B2 (en) 2014-08-29 2019-02-12 Camras Vision Inc. Device and method for reducing intraocular pressure
US10342702B2 (en) 2014-08-29 2019-07-09 Camras Vision Inc. Apparatus and method for reducing intraocular pressure
JP6586172B2 (en) 2014-10-31 2019-10-02 セレバスク, エルエルシーCereVasc, LLC Method and system for treating hydrocephalus
EP3240510A4 (en) 2014-12-31 2018-09-19 Microoptx Inc. Glaucoma treatment devices and methods
WO2016154066A2 (en) 2015-03-20 2016-09-29 Glaukos Corporation Gonioscopic devices
US10299958B2 (en) 2015-03-31 2019-05-28 Sight Sciences, Inc. Ocular delivery systems and methods
UA122570C2 (en) 2015-06-03 2020-12-10 Аквісіс, Інк. Ab externo intraocular shunt placement
EP4265231A3 (en) 2015-08-14 2023-12-20 Alcon Inc. Ocular implant with pressure sensor
WO2017040853A1 (en) 2015-09-02 2017-03-09 Glaukos Corporation Drug delivery implants with bi-directional delivery capacity
JP6646987B2 (en) 2015-09-16 2020-02-14 Hoya株式会社 Intraocular lens insertion device
JPWO2017047714A1 (en) 2015-09-16 2018-07-05 Hoya株式会社 Intraocular lens insertion device
US11564833B2 (en) 2015-09-25 2023-01-31 Glaukos Corporation Punctal implants with controlled drug delivery features and methods of using same
US10524958B2 (en) 2015-09-30 2020-01-07 Alievio, Inc. Method and apparatus for reducing intraocular pressure
WO2017059272A1 (en) 2015-09-30 2017-04-06 Microoptx Inc. Dry eye treatment devices and methods
WO2017070288A1 (en) * 2015-10-21 2017-04-27 The Regents Of The University Of Colorado, A Body Corporate Intraocular devices and methods for correction of aphakia, restoration of accommodation, and treatment of glaucoma
CN108136164B (en) 2015-10-30 2020-12-08 西瑞维斯克公司 Systems and methods for treating hydrocephalus
TW201722377A (en) 2015-12-16 2017-07-01 諾華公司 Devices and methods for a cannula-delivered treatment material application device
EP3426315A1 (en) 2016-03-11 2019-01-16 The Johns Hopkins University Partially degradable stents for controlled reduction of intraocular pressure
CA3022830A1 (en) 2016-04-20 2017-10-26 Harold Alexander Heitzmann Bioresorbable ocular drug delivery device
RU2018142990A (en) 2016-06-02 2020-06-05 Эквисис, Инк. INTERNAL EYE DELIVERY OF MEDICINES
WO2018003854A1 (en) 2016-06-28 2018-01-04 Hoya株式会社 Intraocular lens insertion tool
US10674906B2 (en) 2017-02-24 2020-06-09 Glaukos Corporation Gonioscopes
EP3668460A4 (en) * 2017-08-17 2021-05-05 Aspip Inc. Method, device, and system for treatment of elevated intraocular pressure
WO2019068026A1 (en) 2017-09-29 2019-04-04 Glaukos Corporation Intraocular physiological sensor
AU2018346229A1 (en) 2017-10-06 2020-04-30 Glaukos Corporation Systems and methods for delivering multiple ocular implants
USD846738S1 (en) 2017-10-27 2019-04-23 Glaukos Corporation Implant delivery apparatus
US11246753B2 (en) 2017-11-08 2022-02-15 Aquesys, Inc. Manually adjustable intraocular flow regulation
EP3762083A1 (en) 2018-03-08 2021-01-13 CereVasc, Inc. Systems and methods for minimally invasive drug delivery to a subarachnoid space
US11135089B2 (en) 2018-03-09 2021-10-05 Aquesys, Inc. Intraocular shunt inserter
US10952898B2 (en) 2018-03-09 2021-03-23 Aquesys, Inc. Intraocular shunt inserter
US10369049B1 (en) * 2018-08-17 2019-08-06 Iridex Corporation Probes having fiber taper and fluid collection channel for ophthalmic laser treatment
US11672701B2 (en) 2018-10-25 2023-06-13 Amo Groningen B.V. Bleb control glaucoma shunts
US11925580B2 (en) 2019-06-14 2024-03-12 Iantrek, Inc. Implantable biologic stent and system for biologic material shaping and preparation in the treatment of glaucoma
WO2021003304A1 (en) 2019-07-01 2021-01-07 Berlin Michael S Image guidance methods and apparatus for glaucoma surgery
JP7336910B2 (en) 2019-08-05 2023-09-01 株式会社日清製粉ウェルナ Liquid cheese food containing indigestible dextrin
US11504270B1 (en) 2019-09-27 2022-11-22 Sight Sciences, Inc. Ocular delivery systems and methods
US20210228334A1 (en) * 2020-01-29 2021-07-29 Brockman-Hastings LLC Device for securing an intraocular device in an eye
CA3183402A1 (en) * 2020-05-20 2021-11-25 Iantrek, Inc. System for shaping and implanting biologic intraocular stent for increased aqueous outflow and lowering of intraocular pressure
JP2024503989A (en) 2021-01-11 2024-01-30 アルコン インコーポレイティド Systems and methods for viscoelastic delivery

Family Cites Families (691)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US538291A (en) * 1895-04-30 Type-writer cabinet
US2031754A (en) 1932-11-04 1936-02-25 Ernest J Sweetland Extensible coupling
US2127903A (en) 1936-05-05 1938-08-23 Davis & Geck Inc Tube for surgical purposes and method of preparing and using the same
US2269963A (en) 1940-06-01 1942-01-13 Wappler Frederick Charles Implanting device
US3159161A (en) 1962-11-14 1964-12-01 Ness Richard Alton Fistulizing canaliculus
US3416530A (en) 1966-03-02 1968-12-17 Richard A. Ness Eyeball medication dispensing tablet
US3439675A (en) 1966-06-14 1969-04-22 Becton Dickinson Co Deformable needle assembly
US3915172A (en) 1970-05-27 1975-10-28 Ceskoslovenska Akademie Ved Capillary drain for glaucoma
US3717151A (en) 1971-03-11 1973-02-20 R Collett Flesh penetrating apparatus
US3788327A (en) * 1971-03-30 1974-01-29 H Donowitz Surgical implant device
SE353590B (en) 1971-10-01 1973-02-05 J Kaller
US3948871A (en) 1972-04-21 1976-04-06 George H. Butterfield And Son Composition for hard type contact lens with wettable surface
US3863623A (en) 1972-06-19 1975-02-04 Medical College Of Georgia Fou Method for microscintigraphic evaluation studies
US3948271A (en) 1972-11-07 1976-04-06 Taichiro Akiyama Drain for the eardrum and apparatus for introducing the same
US3976077A (en) 1975-02-03 1976-08-24 Kerfoot Jr Franklin W Eye surgery device
JPS5255402Y2 (en) 1975-04-22 1977-12-14
US4037604A (en) 1976-01-05 1977-07-26 Newkirk John B Artifical biological drainage device
US4043346A (en) 1976-03-10 1977-08-23 Baylor College Of Medicine Catheter
US4030480A (en) 1976-05-13 1977-06-21 Ernst Jochen Meyer Ocular decompression process
US4168697A (en) * 1977-01-17 1979-09-25 Cantekin Erdem I Middle ear ventilating tube and method
US4113088A (en) 1977-06-06 1978-09-12 Binkhorst Richard D Sterile package
US4175563A (en) 1977-10-05 1979-11-27 Arenberg Irving K Biological drainage shunt
US4299227A (en) 1979-10-19 1981-11-10 Lincoff Harvey A Ophthalmological appliance
US4402681A (en) 1980-08-23 1983-09-06 Haas Joseph S Artificial implant valve for the regulation of intraocular pressure
US4366582A (en) 1980-12-01 1983-01-04 Faulkner Gerald D Posterior chamber intraocular lens
NO147900C (en) 1981-03-12 1983-07-06 Finn Skjaerpe MICROSURGICAL INSTRUMENT.
US4457757A (en) 1981-07-20 1984-07-03 Molteno Anthony C B Device for draining aqueous humour
US4428746A (en) 1981-07-29 1984-01-31 Antonio Mendez Glaucoma treatment device
US4449529A (en) 1981-11-18 1984-05-22 Becton Dickinson And Company Automatic retractable lancet assembly
DE3206834A1 (en) 1982-02-26 1983-09-15 Walter Dr. 4000 Düsseldorf Messingschlager DRAINAGE TUBE FOR USE IN AN OPERATIONAL ACCESS TO A BODY RECOVERY
US4501276A (en) * 1982-07-16 1985-02-26 Illinois Tool Works Inc. Fetal electrode apparatus
US4554918A (en) 1982-07-28 1985-11-26 White Thomas C Ocular pressure relief device
JPS5985153A (en) * 1982-11-08 1984-05-17 Hitachi Ltd Redundancy controller
US4521210A (en) 1982-12-27 1985-06-04 Wong Vernon G Eye implant for relieving glaucoma, and device and method for use therewith
FR2553658A1 (en) 1983-10-19 1985-04-26 Neidich Warren Implant valve for curing glaucoma
US4560383A (en) 1983-10-27 1985-12-24 Leiske Larry G Anterior chamber intraocular lens
US4578058A (en) 1984-04-02 1986-03-25 Grandon Stanley C Intraocular catheter apparatus and method of use
US4634418A (en) 1984-04-06 1987-01-06 Binder Perry S Hydrogel seton
US4787885A (en) 1984-04-06 1988-11-29 Binder Perry S Hydrogel seton
DE3447642C1 (en) 1984-12-28 1986-09-18 Bernhard M. Dr. 5600 Wuppertal Cramer Steerable guidewire for catheters
US4604087A (en) 1985-02-26 1986-08-05 Joseph Neil H Aqueous humor drainage device
US4642090A (en) 1985-03-04 1987-02-10 Utrata Peter J Disposable combination scalpel blade and incision irrigator for ophthalmological use
US4820626A (en) * 1985-06-06 1989-04-11 Thomas Jefferson University Method of treating a synthetic or naturally occuring surface with microvascular endothelial cells, and the treated surface itself
US4718907A (en) 1985-06-20 1988-01-12 Atrium Medical Corporation Vascular prosthesis having fluorinated coating with varying F/C ratio
US4632842A (en) 1985-06-20 1986-12-30 Atrium Medical Corporation Glow discharge process for producing implantable devices
US4883864A (en) 1985-09-06 1989-11-28 Minnesota Mining And Manufacturing Company Modified collagen compound and method of preparation
US4733665C2 (en) 1985-11-07 2002-01-29 Expandable Grafts Partnership Expandable intraluminal graft and method and apparatus for implanting an expandable intraluminal graft
US4692142A (en) 1986-02-24 1987-09-08 Dignam Bernard J Sutureless infusion cannula for ophthalmic surgery
NZ215409A (en) 1986-03-07 1989-02-24 Anthony Christopher Be Molteno Implant for drainage of aqueous humour in glaucoma
CH670760A5 (en) * 1986-06-02 1989-07-14 Sulzer Ag
US4722724A (en) 1986-06-23 1988-02-02 Stanley Schocket Anterior chamber tube shunt to an encircling band, and related surgical procedure
US4826478A (en) 1986-06-23 1989-05-02 Stanley Schocket Anterior chamber tube shunt to an encircling band, and related surgical procedure
US4867173A (en) 1986-06-30 1989-09-19 Meadox Surgimed A/S Steerable guidewire
US4863457A (en) 1986-11-24 1989-09-05 Lee David A Drug delivery device
US4782819A (en) 1987-02-25 1988-11-08 Adair Edwin Lloyd Optical catheter
US4846793A (en) * 1987-03-18 1989-07-11 Endocon, Inc. Injector for implanting multiple pellet medicaments
DE3715699A1 (en) 1987-05-12 1988-12-01 Foerster Ernst CATHETER AND ENDOSCOPE FOR THE TRANSPAPILLARY DISPLAY OF THE GALLEN BLADDER
US4846172A (en) 1987-05-26 1989-07-11 Berlin Michael S Laser-delivery eye-treatment method
US4900300A (en) 1987-07-06 1990-02-13 Lee David A Surgical instrument
US4886488A (en) 1987-08-06 1989-12-12 White Thomas C Glaucoma drainage the lacrimal system and method
AU2308988A (en) 1987-08-06 1989-03-01 Thomas C. White Glaucoma drainage in the lacrimal system
EP0375676A1 (en) 1987-08-19 1990-07-04 BERG, Olle A drainage tube for sinus maxillaris, a means for its insertion and a means for making a hole for its positioning
US4870953A (en) 1987-11-13 1989-10-03 Donmicheal T Anthony Intravascular ultrasonic catheter/probe and method for treating intravascular blockage
US4997652A (en) * 1987-12-22 1991-03-05 Visionex Biodegradable ocular implants
US4853224A (en) 1987-12-22 1989-08-01 Visionex Biodegradable ocular implants
US5053044A (en) 1988-01-11 1991-10-01 Devices For Vascular Intervention, Inc. Catheter and method for making intravascular incisions
US4800870A (en) 1988-03-11 1989-01-31 Reid Jr Ben A Method and apparatus for bile duct exploration
US4936825A (en) 1988-04-11 1990-06-26 Ungerleider Bruce A Method for reducing intraocular pressure caused by glaucoma
CA1334168C (en) 1988-04-26 1995-01-31 Louis M. De Santis Antiglaucoma compositions containing combinations of .alpha.-2 agonists and .beta. blockers
US5005577A (en) * 1988-08-23 1991-04-09 Frenkel Ronald E P Intraocular lens pressure monitoring device
AU4191989A (en) 1988-08-24 1990-03-23 Marvin J. Slepian Biodegradable polymeric endoluminal sealing
US5681275A (en) 1988-10-07 1997-10-28 Ahmed; Abdul Mateen Ophthalmological device with adaptable multiple distribution plates
US5785674A (en) 1988-10-07 1998-07-28 Mateen; Ahmed Abdul Device and method for treating glaucoma
US5116327A (en) 1989-06-05 1992-05-26 Helix Medical, Inc. Hysterectomy drain appliance
US4991602A (en) 1989-06-27 1991-02-12 Flexmedics Corporation Flexible guide wire with safety tip
SG49267A1 (en) 1989-08-14 1998-05-18 Photogenesis Inc Surgical instrument and cell isolation and transplantation
US5817075A (en) 1989-08-14 1998-10-06 Photogenesis, Inc. Method for preparation and transplantation of planar implants and surgical instrument therefor
US4986810A (en) 1989-09-01 1991-01-22 Neal Semrad Toggle catheter
US5169386A (en) 1989-09-11 1992-12-08 Bruce B. Becker Method and catheter for dilatation of the lacrimal system
FR2651668B1 (en) * 1989-09-12 1991-12-27 Leon Claude MICROSCOPE-ENDOSCOPE ASSEMBLY USEFUL IN PARTICULAR IN SURGERY.
US5053040A (en) 1989-11-09 1991-10-01 Goldsmith Iii Manning M Method of performing a myringotomy
USRE35390E (en) 1989-11-17 1996-12-03 Smith; Stewart G. Pressure relieving device and process for implanting
US4946436A (en) 1989-11-17 1990-08-07 Smith Stewart G Pressure-relieving device and process for implanting
US5164188A (en) 1989-11-22 1992-11-17 Visionex, Inc. Biodegradable ocular implants
US5180632A (en) * 1989-12-18 1993-01-19 Carapace Orthopedic casting material having reduced tack and reduced slip
US4968296A (en) * 1989-12-20 1990-11-06 Robert Ritch Transscleral drainage implant device for the treatment of glaucoma
US5092837A (en) * 1989-12-20 1992-03-03 Robert Ritch Method for the treatment of glaucoma
DE4030004A1 (en) 1990-01-05 1992-03-26 Heino Dr Hermeking INSTRUMENT WITH HOOK PLATE FOR IMPLANTING AN ARTIFICIAL LENS
US5221255A (en) 1990-01-10 1993-06-22 Mahurkar Sakharam D Reinforced multiple lumen catheter
US5073163A (en) 1990-01-29 1991-12-17 Lippman Myron E Apparatus for treating glaucoma
RU2022539C1 (en) 1990-01-29 1994-11-15 Мир Сергеевич Ремизов Method of treating glaucoma
US5180362A (en) 1990-04-03 1993-01-19 Worst J G F Gonio seton
US5129895A (en) 1990-05-16 1992-07-14 Sunrise Technologies, Inc. Laser sclerostomy procedure
US5041081A (en) * 1990-05-18 1991-08-20 Odrich Ronald B Ocular implant for controlling glaucoma
US5127901A (en) * 1990-05-18 1992-07-07 Odrich Ronald B Implant with subconjunctival arch
US5397300A (en) 1990-05-31 1995-03-14 Iovision, Inc. Glaucoma implant
US5178604A (en) 1990-05-31 1993-01-12 Iovision, Inc. Glaucoma implant
US5476445A (en) 1990-05-31 1995-12-19 Iovision, Inc. Glaucoma implant with a temporary flow restricting seal
WO1992000112A1 (en) 1990-06-25 1992-01-09 Ungerleider Bruce A Apparatus for reducing intraocular pressure
US5725529A (en) 1990-09-25 1998-03-10 Innovasive Devices, Inc. Bone fastener
US5688261A (en) 1990-11-07 1997-11-18 Premier Laser Systems, Inc. Transparent laser surgical probe
US5273530A (en) * 1990-11-14 1993-12-28 The University Of Rochester Intraretinal delivery and withdrawal instruments
US5454796A (en) 1991-04-09 1995-10-03 Hood Laboratories Device and method for controlling intraocular fluid pressure
US5312394A (en) 1991-04-29 1994-05-17 Hugh Beckman Apparatus and method for surgically performing a filtering operation on an eye for glaucoma
US5246451A (en) 1991-04-30 1993-09-21 Medtronic, Inc. Vascular prosthesis and method
US5358492A (en) 1991-05-02 1994-10-25 Feibus Miriam H Woven surgical drain and method of making
US6007511A (en) 1991-05-08 1999-12-28 Prywes; Arnold S. Shunt valve and therapeutic delivery system for treatment of glaucoma and methods and apparatus for its installation
US5300020A (en) * 1991-05-31 1994-04-05 Medflex Corporation Surgically implantable device for glaucoma relief
US5171213A (en) 1991-08-14 1992-12-15 Price Jr Francis W Technique for fistulization of the eye and an eye filtration prosthesis useful therefor
US5326345A (en) 1991-08-14 1994-07-05 Price Jr Francis W Eye filtration prostheses
US5500013A (en) 1991-10-04 1996-03-19 Scimed Life Systems, Inc. Biodegradable drug delivery vascular stent
GB2260585A (en) 1991-10-09 1993-04-21 Avdel Systems Ltd Self-plugging blind rivet
US5290310A (en) 1991-10-30 1994-03-01 Howmedica, Inc. Hemostatic implant introducer
US5360399A (en) 1992-01-10 1994-11-01 Robert Stegmann Method and apparatus for maintaining the normal intraocular pressure
US5207685A (en) * 1992-02-11 1993-05-04 Cinberg James Z Tympanic ventilation tube and related technique
US5334137A (en) 1992-02-21 1994-08-02 Eagle Vision, Inc. Lacrimal fluid control device
US5346464A (en) 1992-03-10 1994-09-13 Camras Carl B Method and apparatus for reducing intraocular pressure
US5284476A (en) * 1992-03-20 1994-02-08 Koch Paul S Nuclear hydrolysis cannula
US5415666A (en) 1992-03-23 1995-05-16 Advanced Surgical, Inc. Tethered clamp retractor
AU4282793A (en) 1992-04-10 1993-11-18 State Of Oregon Acting By And Through The Oregon State Board Of Higher Education On Behalf Of The Oregon Health Sciences University A microneedle for injection of ocular blood vessels
US5368601A (en) 1992-04-30 1994-11-29 Lasersurge, Inc. Trocar wound closure device
US5370641A (en) 1992-05-22 1994-12-06 O'donnell, Jr.; Francis E. Laser trabeculodissection
US5663205A (en) 1992-05-22 1997-09-02 Senju Pharmaceutical Co. Ltd. Pharmaceutical composition for use in glaucoma treatment
DE4219299C2 (en) 1992-06-12 1994-03-24 Leica Mikroskopie & Syst microscope
US5767079A (en) 1992-07-08 1998-06-16 Celtrix Pharmaceuticals, Inc. Method of treating ophthalmic disorders using TGF -β
US5290295A (en) * 1992-07-15 1994-03-01 Querals & Fine, Inc. Insertion tool for an intraluminal graft procedure
US6197056B1 (en) * 1992-07-15 2001-03-06 Ras Holding Corp. Segmented scleral band for treatment of presbyopia and other eye disorders
WO1994002081A1 (en) 1992-07-16 1994-02-03 Wong Vernon G Eye implant suitable for relief of glaucoma
JP3739411B2 (en) 1992-09-08 2006-01-25 敬二 伊垣 Vascular stent, manufacturing method thereof, and vascular stent device
US5318513A (en) * 1992-09-24 1994-06-07 Leib Martin L Canalicular balloon fixation stent
US5370607A (en) 1992-10-28 1994-12-06 Annuit Coeptis, Inc. Glaucoma implant device and method for implanting same
WO1994013234A1 (en) 1992-12-17 1994-06-23 Michael Andrew Coote Implant device and method for treatment of glaucoma
US5338291A (en) 1993-02-03 1994-08-16 Pudenz-Schulte Medical Research Corporation Glaucoma shunt and method for draining aqueous humor
DE4304838C2 (en) * 1993-02-17 1996-01-25 Daimler Benz Ag Device for determining the usage fees of the web
SG49754A1 (en) 1993-03-16 1998-06-15 Photogenesis Inc Method for preparation and transplantation of volute grafts and surgical instrument therefor
US5342370A (en) 1993-03-19 1994-08-30 University Of Miami Method and apparatus for implanting an artifical meshwork in glaucoma surgery
IL105828A (en) 1993-05-28 1999-06-20 Medinol Ltd Medical stent
US5731294A (en) 1993-07-27 1998-03-24 Hybridon, Inc. Inhibition of neovasularization using VEGF-specific oligonucleotides
US6184250B1 (en) 1993-08-03 2001-02-06 Alcon Laboratories, Inc. Use of cloprostenol and fluprostenol analogues to treat glaucoma and ocular hypertension
US5653724A (en) * 1993-08-18 1997-08-05 Imonti; Maurice M. Angled phacoemulsifier tip
US5735892A (en) 1993-08-18 1998-04-07 W. L. Gore & Associates, Inc. Intraluminal stent graft
FR2710269A1 (en) 1993-09-22 1995-03-31 Voir Vivre Implantable device for the treatment of edemas.
FI934513A (en) 1993-10-13 1995-04-14 Leiras Oy Anordning Foer injection with implant
US5639278A (en) 1993-10-21 1997-06-17 Corvita Corporation Expandable supportive bifurcated endoluminal grafts
US5695479A (en) 1993-11-01 1997-12-09 Jagpal; Ravindar Instrument, system, kit and method for catheterization procedures
US5443505A (en) 1993-11-15 1995-08-22 Oculex Pharmaceuticals, Inc. Biocompatible ocular implants
US5479222A (en) 1993-11-15 1995-12-26 Volk; Donald A. Indirect ophthalmoscopy lens system and adapter lenses
US5445637A (en) 1993-12-06 1995-08-29 American Cyanamid Company Method and apparatus for preventing posterior capsular opacification
AU686315B2 (en) 1994-02-07 1998-02-05 Kabushikikaisya Igaki Iryo Sekkei Stent device and stent supply system
US5743868A (en) 1994-02-14 1998-04-28 Brown; Reay H. Corneal pressure-regulating implant device
US6135977A (en) 1994-02-16 2000-10-24 Possis Medical, Inc. Rheolytic catheter
US5516522A (en) * 1994-03-14 1996-05-14 Board Of Supervisors Of Louisiana State University Biodegradable porous device for long-term drug delivery with constant rate release and method of making the same
US6165210A (en) 1994-04-01 2000-12-26 Gore Enterprise Holdings, Inc. Self-expandable helical intravascular stent and stent-graft
AU704591B2 (en) 1994-04-04 1999-04-29 William R. Freeman Use of phosphonylmethoxyalkyl nucleosides for the treatment of raised intraocular pressure
US5716394A (en) * 1994-04-29 1998-02-10 W. L. Gore & Associates, Inc. Blood contact surfaces using extracellular matrix synthesized in vitro
IL109499A (en) * 1994-05-02 1998-01-04 Univ Ramot Implant device for draining excess intraocular fluid
FR2721499B1 (en) 1994-06-22 1997-01-03 Opsia Trabeculectomy implant.
US5725546A (en) 1994-06-24 1998-03-10 Target Therapeutics, Inc. Detachable microcoil delivery catheter
US6405732B1 (en) 1994-06-24 2002-06-18 Curon Medical, Inc. Method to treat gastric reflux via the detection and ablation of gastro-esophageal nerves and receptors
US6177427B1 (en) 1994-06-28 2001-01-23 Alcon Laboratories, Inc. Treatment of glaucoma and ocular hypertension
US5704907A (en) 1994-07-22 1998-01-06 Wound Healing Of Oklahoma Method and apparatus for lowering the intraocular pressure of an eye
US6102045A (en) 1994-07-22 2000-08-15 Premier Laser Systems, Inc. Method and apparatus for lowering the intraocular pressure of an eye
US5520631A (en) 1994-07-22 1996-05-28 Wound Healing Of Oklahoma Method and apparatus for lowering the intraocular pressure of an eye
US5665114A (en) 1994-08-12 1997-09-09 Meadox Medicals, Inc. Tubular expanded polytetrafluoroethylene implantable prostheses
SE9402816D0 (en) 1994-08-24 1994-08-24 Pharmacia Ab Method and meams for drug administration
FR2724057B1 (en) * 1994-08-26 1996-10-18 Alcatel Nv METHOD FOR PRODUCING A MARK ON A PARTICULARLY SEMICONDUCTOR WAFER INCLUDING AN UNDERGROUND STRUCTURE
US5462558A (en) 1994-08-29 1995-10-31 United States Surgical Corporation Suture clip applier
DE4433104C1 (en) 1994-09-16 1996-05-02 Fraunhofer Ges Forschung Device for measuring mechanical properties of biological tissue
US5702419A (en) 1994-09-21 1997-12-30 Wake Forest University Expandable, intraluminal stents
US6063396A (en) * 1994-10-26 2000-05-16 Houston Biotechnology Incorporated Methods and compositions for the modulation of cell proliferation and wound healing
US6063116A (en) * 1994-10-26 2000-05-16 Medarex, Inc. Modulation of cell proliferation and wound healing
US5643321A (en) 1994-11-10 1997-07-01 Innovasive Devices Suture anchor assembly and methods
JP3642812B2 (en) * 1994-11-17 2005-04-27 株式会社町田製作所 Medical observation device
US5601094A (en) 1994-11-22 1997-02-11 Reiss; George R. Ophthalmic shunt
US5602143A (en) 1994-12-08 1997-02-11 Allergan Method for reducing intraocular pressure in the mammalian eye by administration of guanylate cyclase inhibitors
US6228873B1 (en) * 1994-12-09 2001-05-08 The Regents Of The University Of California Method for enhancing outflow of aqueous humor in treatment of glaucoma
US5725493A (en) * 1994-12-12 1998-03-10 Avery; Robert Logan Intravitreal medicine delivery
US5433701A (en) * 1994-12-21 1995-07-18 Rubinstein; Mark H. Apparatus for reducing ocular pressure
US5891084A (en) 1994-12-27 1999-04-06 Lee; Vincent W. Multiple chamber catheter delivery system
US5556400A (en) 1994-12-27 1996-09-17 Tunis; Scott W. Methods of preparing and inserting flexible intraocular lenses and a configuration for flexible intraocular lenses
US5558630A (en) 1994-12-30 1996-09-24 Fisher; Bret L. Intrascleral implant and method for the regulation of intraocular pressure
GB2296663A (en) 1995-01-03 1996-07-10 Ahmed Salih Mahmud Drainage device for alleviating excess ophthalmic fluid pressure
WO1996020742A1 (en) 1995-01-06 1996-07-11 Wong Vernon G Improve eye implant for relief of glaucoma
JPH10513455A (en) 1995-02-10 1998-12-22 ザ ユニバーシティ オブ トロント イノベーションズ ファウンデーション Deprenyl compounds for the treatment of glaucoma
US5792099A (en) 1995-02-14 1998-08-11 Decamp; Dennis Syringe and cannula for insertion of viscoelastic material into an eye and method of using same
US6059772A (en) 1995-03-10 2000-05-09 Candela Corporation Apparatus and method for treating glaucoma using a gonioscopic laser trabecular ablation procedure
BE1009278A3 (en) 1995-04-12 1997-01-07 Corvita Europ Guardian self-expandable medical device introduced in cavite body, and medical device with a stake as.
US5626558A (en) 1995-05-05 1997-05-06 Suson; John Adjustable flow rate glaucoma shunt and method of using same
CN1283324C (en) * 1995-05-14 2006-11-08 奥普通诺尔有限公司 Intraocular implant, delivery device, and method of implantation
US5968058A (en) 1996-03-27 1999-10-19 Optonol Ltd. Device for and method of implanting an intraocular implant
IL113723A (en) * 1995-05-14 2002-11-10 Optonol Ltd Intraocular implant
WO1996037167A1 (en) 1995-05-25 1996-11-28 Raychem Corporation Stent assembly
US5723005A (en) * 1995-06-07 1998-03-03 Herrick Family Limited Partnership Punctum plug having a collapsible flared section and method
AU5776696A (en) 1995-06-08 1997-01-09 Bard Galway Limited Bifurcated endovascular stent
US6194415B1 (en) 1995-06-28 2001-02-27 Allergan Sales, Inc. Method of using (2-imidazolin-2-ylamino) quinoxoalines in treating neural injury
US5913852A (en) 1995-07-21 1999-06-22 Nemours Foundation Drain cannula
US5934285A (en) 1995-07-27 1999-08-10 Michiel S. Kritzinger Method for reducing irregular astigmatism and debris/epithelium in the interface during lamellar corneal flap/cap surgery
US5766243A (en) * 1995-08-21 1998-06-16 Oasis Medical, Inc. Abrasive polished canalicular implant
US5662600A (en) 1995-09-29 1997-09-02 Pudenz-Schulte Medical Research Corporation Burr-hole flow control device
US6099558A (en) 1995-10-10 2000-08-08 Edwards Lifesciences Corp. Intraluminal grafting of a bifuricated artery
US5547993A (en) 1995-10-24 1996-08-20 Mitsubishi Chemical Corporation Therapeutic agent for glaucoma
US5836939A (en) 1995-10-25 1998-11-17 Plc Medical Systems, Inc. Surgical laser handpiece
US5741292A (en) 1995-10-26 1998-04-21 Eagle Vision Punctum dilating and plug inserting instrument with push-button plug release
US5651783A (en) 1995-12-20 1997-07-29 Reynard; Michael Fiber optic sleeve for surgical instruments
US5722948A (en) 1996-02-14 1998-03-03 Gross; Fredric J. Covering for an ocular device
US5798380A (en) 1996-02-21 1998-08-25 Wisconsin Alumni Research Foundation Cytoskeletal active agents for glaucoma therapy
US6299895B1 (en) 1997-03-24 2001-10-09 Neurotech S.A. Device and method for treating ophthalmic diseases
US5807302A (en) * 1996-04-01 1998-09-15 Wandel; Thaddeus Treatment of glaucoma
JP3792775B2 (en) * 1996-04-08 2006-07-05 有限会社エム・エル・シー Lacrimal intubation device
US5830179A (en) 1996-04-09 1998-11-03 Endocare, Inc. Urological stent therapy system and method
US6629981B2 (en) 2000-07-06 2003-10-07 Endocare, Inc. Stent delivery system
US5865831A (en) 1996-04-17 1999-02-02 Premier Laser Systems, Inc. Laser surgical procedures for treatment of glaucoma
NL1002898C2 (en) 1996-04-18 1997-10-21 Cordis Europ Catheter with marker sleeve.
US5932299A (en) 1996-04-23 1999-08-03 Katoot; Mohammad W. Method for modifying the surface of an object
US6530896B1 (en) * 1996-05-13 2003-03-11 James B. Elliott Apparatus and method for introducing an implant
US5670161A (en) 1996-05-28 1997-09-23 Healy; Kevin E. Biodegradable stent
US5669501A (en) 1996-06-05 1997-09-23 Xomed Surgical Products, Inc. Package and method for delivering a medical implant
US5681323A (en) 1996-07-15 1997-10-28 Arick; Daniel S. Emergency cricothyrotomy tube insertion
US5755682A (en) 1996-08-13 1998-05-26 Heartstent Corporation Method and apparatus for performing coronary artery bypass surgery
US5830139A (en) 1996-09-04 1998-11-03 Abreu; Marcio M. Tonometer system for measuring intraocular pressure by applanation and/or indentation
US6120460A (en) 1996-09-04 2000-09-19 Abreu; Marcio Marc Method and apparatus for signal acquisition, processing and transmission for evaluation of bodily functions
US5655548A (en) 1996-09-16 1997-08-12 Circulation, Inc. Method for treatment of ischemic heart disease by providing transvenous myocardial perfusion
RU2143250C1 (en) 1996-09-25 1999-12-27 Астахов Сергей Юрьевич Method for treating patients suffering from a combination of glaucoma and cataract
US5733256A (en) 1996-09-26 1998-03-31 Micro Medical Devices Integrated phacoemulsification system
US5886822A (en) * 1996-10-08 1999-03-23 The Microoptical Corporation Image combining system for eyeglasses and face masks
US6007510A (en) 1996-10-25 1999-12-28 Anamed, Inc. Implantable devices and methods for controlling the flow of fluids within the body
US6881197B1 (en) 1996-10-25 2005-04-19 Anamed, Inc. Sutureless implantable device and method for treatment of glaucoma
US5925342A (en) 1996-11-13 1999-07-20 Allergan Method for reducing intraocular pressure in the mammalian eye by administration of potassium channel blockers
US5807244A (en) 1996-11-15 1998-09-15 Barot; Jagdish Shantilal Single use disposable iris retractor
US5941250A (en) 1996-11-21 1999-08-24 University Of Louisville Research Foundation Inc. Retinal tissue implantation method
AUPO394496A0 (en) 1996-11-29 1997-01-02 Lions Eye Institute Biological microfistula tube and implantation method and apparatus
FR2757068B1 (en) 1996-12-13 1999-04-23 Jussmann Alberto SELF-FIXING DRAIN
DE19651951C2 (en) 1996-12-16 2002-06-27 Adeva Medical Ges Fuer Entwick Shunt valve
US6261256B1 (en) 1996-12-20 2001-07-17 Abdul Mateen Ahmed Pocket medical valve & method
GB9700390D0 (en) 1997-01-10 1997-02-26 Biocompatibles Ltd Device for use in the eye
US5713844A (en) * 1997-01-10 1998-02-03 Peyman; Gholam A. Device and method for regulating intraocular pressure
US6780165B2 (en) 1997-01-22 2004-08-24 Advanced Medical Optics Micro-burst ultrasonic power delivery
DE19705815C2 (en) 1997-02-15 1999-02-11 Heidelberg Engineering Optisch Medical device for microsurgery on the eye
FR2759577B1 (en) 1997-02-17 1999-08-06 Corneal Ind DEEP SCLERECTOMY IMPLANT
US6071286A (en) 1997-02-19 2000-06-06 Mawad; Michel E. Combination angioplasty balloon/stent deployment device
US5893837A (en) 1997-02-28 1999-04-13 Staar Surgical Company, Inc. Glaucoma drain implanting device and method
US6059812A (en) 1997-03-21 2000-05-09 Schneider (Usa) Inc. Self-expanding medical device for centering radioactive treatment sources in body vessels
JP3827429B2 (en) 1997-04-03 2006-09-27 オリンパス株式会社 Surgical microscope
US5882327A (en) 1997-04-17 1999-03-16 Jacob; Jean T. Long-term glaucoma drainage implant
US6050970A (en) 1997-05-08 2000-04-18 Pharmacia & Upjohn Company Method and apparatus for inserting a glaucoma implant in an anterior and posterior segment of the eye
US5752928A (en) 1997-07-14 1998-05-19 Rdo Medical, Inc. Glaucoma pressure regulator
US5980928A (en) 1997-07-29 1999-11-09 Terry; Paul B. Implant for preventing conjunctivitis in cattle
US5830171A (en) 1997-08-12 1998-11-03 Odyssey Medical, Inc. Punctal occluder
EP0898947A3 (en) 1997-08-15 1999-09-08 GRIESHABER & CO. AG SCHAFFHAUSEN Method and apparatus to improve the outflow of the aqueous humor of an eye
US6004302A (en) 1997-08-28 1999-12-21 Brierley; Lawrence A. Cannula
US6274138B1 (en) 1997-09-03 2001-08-14 Incyte Genomics, Inc. Human mitochondrial malate dehydrogenase
US6159458A (en) 1997-11-04 2000-12-12 Insite Vision Sustained release ophthalmic compositions containing water soluble medicaments
US6203513B1 (en) 1997-11-20 2001-03-20 Optonol Ltd. Flow regulating implant, method of manufacture, and delivery device
US8313454B2 (en) * 1997-11-20 2012-11-20 Optonol Ltd. Fluid drainage device, delivery device, and associated methods of use and manufacture
US6036682A (en) 1997-12-02 2000-03-14 Scimed Life Systems, Inc. Catheter having a plurality of integral radiopaque bands
EP1039847A1 (en) 1997-12-15 2000-10-04 Prolifix Medical, Inc. Vascular stent for reduction of restenosis
US5927585A (en) 1997-12-17 1999-07-27 Senco Products, Inc. Electric multiple impact fastener driving tool
US6050999A (en) 1997-12-18 2000-04-18 Keravision, Inc. Corneal implant introducer and method of use
US6589198B1 (en) 1998-01-29 2003-07-08 David Soltanpour Implantable micro-pump assembly
US6682500B2 (en) 1998-01-29 2004-01-27 David Soltanpour Synthetic muscle based diaphragm pump apparatuses
US7780623B2 (en) 1998-01-29 2010-08-24 Soltanpour David P Implantable pump apparatuses
US6168575B1 (en) * 1998-01-29 2001-01-02 David Pyam Soltanpour Method and apparatus for controlling intraocular pressure
US6224570B1 (en) 1998-02-06 2001-05-01 Possis Medical, Inc. Rheolytic thrombectomy catheter and method of using same
US6030416A (en) 1998-02-13 2000-02-29 Pharmacia & Upjohn Ab Medical implants of stretch-crystallizable elastomers and methods of implantation
EP1071414A1 (en) 1998-04-24 2001-01-31 Mitokor Compounds and methods for treating mitochondria-associated diseases
US6371960B2 (en) 1998-05-19 2002-04-16 Bausch & Lomb Surgical, Inc. Device for inserting a flexible intraocular lens
US6231853B1 (en) 1998-06-01 2001-05-15 Incyte Pharmaceuticals, Inc. Human glutathione peroxidase-6
US6306114B1 (en) 1998-06-16 2001-10-23 Eagle Vision, Inc. Valved canalicular plug for lacrimal duct occlusion
US6077299A (en) * 1998-06-22 2000-06-20 Eyetronic, Llc Non-invasively adjustable valve implant for the drainage of aqueous humor in glaucoma
US6319274B1 (en) 1998-06-22 2001-11-20 John H. Shadduck Devices and techniques for light-mediated stimulation of trabecular meshwork in glaucoma therapy
US6402734B1 (en) 1998-07-02 2002-06-11 Jeffrey N. Weiss Apparatus and method for cannulating retinal blood vessels
US6591838B2 (en) 1998-07-06 2003-07-15 Scimed Life Systems, Inc. Implant system and method for bulking tissue
US6378526B1 (en) 1998-08-03 2002-04-30 Insite Vision, Incorporated Methods of ophthalmic administration
US6309374B1 (en) 1998-08-03 2001-10-30 Insite Vision Incorporated Injection apparatus and method of using same
US6146387A (en) 1998-08-26 2000-11-14 Linvatec Corporation Cannulated tissue anchor system
DE19840047B4 (en) 1998-09-02 2004-07-08 Neuhann, Thomas, Prof.Dr.med. Device for the targeted improvement and / or permanent guarantee of the permeability for eye chamber water through the trabecular mechanism in the Schlemm's Canal
KR100300527B1 (en) 1998-09-03 2001-10-27 윤덕용 Remote pressure monitoring device of sealed type and manufacture method for the same
EP1112043B1 (en) 1998-09-10 2006-04-05 Percardia, Inc. Tmr shunt
US6290728B1 (en) 1998-09-10 2001-09-18 Percardia, Inc. Designs for left ventricular conduit
US6264668B1 (en) 1998-09-16 2001-07-24 Arnold S. Prywes Ophthalmologic instrument for producing a fistula in the sclera
EP1447058A1 (en) 1998-09-30 2004-08-18 Bard Peripheral Vascular, Inc. Delivery mechanism for implantable stent
US6241721B1 (en) 1998-10-09 2001-06-05 Colette Cozean Laser surgical procedures for treatment of glaucoma
SE9803481D0 (en) 1998-10-13 1998-10-13 Pharmacia & Upjohn Ab Photocurable siloxane polymers
US6254612B1 (en) 1998-10-22 2001-07-03 Cordis Neurovascular, Inc. Hydraulic stent deployment system
US6454787B1 (en) 1998-12-11 2002-09-24 C. R. Bard, Inc. Collagen hemostatic foam
GB9827415D0 (en) 1998-12-11 1999-02-03 Wild Andrew M Surgical apparatus and method for occluding a body passageway
US6363938B2 (en) 1998-12-22 2002-04-02 Angiotrax, Inc. Methods and apparatus for perfusing tissue and/or stimulating revascularization and tissue growth
US6074395A (en) 1999-02-02 2000-06-13 Linvatec Corporation Cannulated tissue anchor insertion system
US6348042B1 (en) * 1999-02-02 2002-02-19 W. Lee Warren, Jr. Bioactive shunt
US6193656B1 (en) * 1999-02-08 2001-02-27 Robert E. Jeffries Intraocular pressure monitoring/measuring apparatus and method
US6231597B1 (en) 1999-02-16 2001-05-15 Mark E. Deem Apparatus and methods for selectively stenting a portion of a vessel wall
US6217895B1 (en) * 1999-03-22 2001-04-17 Control Delivery Systems Method for treating and/or preventing retinal diseases with sustained release corticosteroids
BR0010055A (en) 1999-04-26 2002-04-09 Gmp Vision Solutions Inc Bypass device and use thereof
US20050119601A9 (en) * 1999-04-26 2005-06-02 Lynch Mary G. Shunt device and method for treating glaucoma
US6699210B2 (en) 1999-04-27 2004-03-02 The Arizona Board Of Regents Glaucoma shunt and a method of making and surgically implanting the same
DE19920615A1 (en) 1999-05-05 2000-12-07 Tui Laser Ag Device for treating glaucorn of the eye
US6342058B1 (en) * 1999-05-14 2002-01-29 Valdemar Portney Iris fixated intraocular lens and instrument for attaching same to an iris
US6558342B1 (en) * 1999-06-02 2003-05-06 Optonol Ltd. Flow control device, introducer and method of implanting
US6306132B1 (en) 1999-06-17 2001-10-23 Vivant Medical Modular biopsy and microwave ablation needle delivery apparatus adapted to in situ assembly and method of use
US6221078B1 (en) 1999-06-25 2001-04-24 Stephen S. Bylsma Surgical implantation apparatus
US20080277007A1 (en) 1999-06-28 2008-11-13 California Institute Of Technology Microfabricated elastomeric valve and pump systems
US6899137B2 (en) 1999-06-28 2005-05-31 California Institute Of Technology Microfabricated elastomeric valve and pump systems
DK1065378T3 (en) 1999-06-28 2002-07-29 California Inst Of Techn Elastomeric micropump and micro valve systems
US8550119B2 (en) 1999-06-28 2013-10-08 California Institute Of Technology Microfabricated elastomeric valve and pump systems
US7144616B1 (en) 1999-06-28 2006-12-05 California Institute Of Technology Microfabricated elastomeric valve and pump systems
US6201001B1 (en) 1999-08-02 2001-03-13 Abbott Laboratories Imidazole antiproliferative agents
US7033603B2 (en) * 1999-08-06 2006-04-25 Board Of Regents The University Of Texas Drug releasing biodegradable fiber for delivery of therapeutics
WO2001013832A1 (en) 1999-08-23 2001-03-01 Conceptus, Inc. Insertion/deployment catheter system for intrafallopian contraception
US6605053B1 (en) 1999-09-10 2003-08-12 Percardia, Inc. Conduit designs and related methods for optimal flow control
US6187016B1 (en) * 1999-09-14 2001-02-13 Daniel G. Hedges Stent retrieval device
ATE283013T1 (en) 1999-10-21 2004-12-15 Alcon Inc MEDICATION DELIVERY DEVICE
US6416777B1 (en) 1999-10-21 2002-07-09 Alcon Universal Ltd. Ophthalmic drug delivery device
US6331313B1 (en) 1999-10-22 2001-12-18 Oculex Pharmaceticals, Inc. Controlled-release biocompatible ocular drug delivery implant devices and methods
US6579235B1 (en) * 1999-11-01 2003-06-17 The Johns Hopkins University Method for monitoring intraocular pressure using a passive intraocular pressure sensor and patient worn monitoring recorder
US7758624B2 (en) 2000-11-13 2010-07-20 C. R. Bard, Inc. Implant delivery device
US6287313B1 (en) 1999-11-23 2001-09-11 Sdgi Holdings, Inc. Screw delivery system and method
JP2003514616A (en) 1999-11-24 2003-04-22 グリースハーバー ウント コンパニー アーゲー シャフハウゼン Apparatus for improving the outflow of aqueous humor in a living eye
DE29920949U1 (en) 1999-11-29 2000-04-27 Bugge Mogens Suction tube for surgical purposes
US20020072673A1 (en) 1999-12-10 2002-06-13 Yamamoto Ronald K. Treatment of ocular disease
US6450937B1 (en) 1999-12-17 2002-09-17 C. R. Bard, Inc. Needle for implanting brachytherapy seeds
WO2001049227A1 (en) 2000-01-03 2001-07-12 Johns Hopkins University Surgical devices and methods of use thereof for enhanced tactile perception
WO2001049352A2 (en) 2000-01-03 2001-07-12 Johns Hopkins University Device and method for manual retinal vein catheterization
US6726676B2 (en) 2000-01-05 2004-04-27 Grieshaber & Co. Ag Schaffhausen Method of and device for improving the flow of aqueous humor within the eye
PL362931A1 (en) 2000-01-12 2004-11-02 Becton, Dickinson And Company Systems and methods for reducing intraocular pressure
US20050119737A1 (en) 2000-01-12 2005-06-02 Bene Eric A. Ocular implant and methods for making and using same
US20030212383A1 (en) 2001-01-05 2003-11-13 Dana Cote System and methods for reducing intraocular pressure
US6589203B1 (en) 2000-01-26 2003-07-08 Peter Mitrev Glaucoma drainage device implant
US6375642B1 (en) 2000-02-15 2002-04-23 Grieshaber & Co. Ag Schaffhausen Method of and device for improving a drainage of aqueous humor within the eye
US6471666B1 (en) 2000-02-24 2002-10-29 Steven A. Odrich Injectable glaucoma device
US6623283B1 (en) 2000-03-08 2003-09-23 Autosplice, Inc. Connector with base having channels to facilitate surface mount solder attachment
US7077848B1 (en) 2000-03-11 2006-07-18 John Hopkins University Sutureless occular surgical methods and instruments for use in such methods
US6613343B2 (en) 2000-04-12 2003-09-02 Pharmacia Groningen Bv Injectable intraocular accommodating lens
US6533768B1 (en) 2000-04-14 2003-03-18 The Regents Of The University Of California Device for glaucoma treatment and methods thereof
US6638239B1 (en) 2000-04-14 2003-10-28 Glaukos Corporation Apparatus and method for treating glaucoma
US7135009B2 (en) * 2001-04-07 2006-11-14 Glaukos Corporation Glaucoma stent and methods thereof for glaucoma treatment
US20020143284A1 (en) 2001-04-03 2002-10-03 Hosheng Tu Drug-releasing trabecular implant for glaucoma treatment
US20040111050A1 (en) * 2000-04-14 2004-06-10 Gregory Smedley Implantable ocular pump to reduce intraocular pressure
US7708711B2 (en) 2000-04-14 2010-05-04 Glaukos Corporation Ocular implant with therapeutic agents and methods thereof
US7867186B2 (en) 2002-04-08 2011-01-11 Glaukos Corporation Devices and methods for treatment of ocular disorders
US20030060752A1 (en) * 2000-04-14 2003-03-27 Olav Bergheim Glaucoma device and methods thereof
US20050049578A1 (en) * 2000-04-14 2005-03-03 Hosheng Tu Implantable ocular pump to reduce intraocular pressure
US20050277864A1 (en) * 2000-04-14 2005-12-15 David Haffner Injectable gel implant for glaucoma treatment
GB0010871D0 (en) 2000-05-06 2000-06-28 Duckworth & Kent Ltd Opthalmic injector
ATE464031T1 (en) 2000-05-08 2010-04-15 Optima Ltd I NON-PENETRATING FILTRATION SURGERY
US9603741B2 (en) 2000-05-19 2017-03-28 Michael S. Berlin Delivery system and method of use for the eye
CA2446143C (en) * 2000-05-19 2010-01-19 Michael S. Berlin Delivery system and method of use for the eye
US8679089B2 (en) 2001-05-21 2014-03-25 Michael S. Berlin Glaucoma surgery methods and systems
US6561974B1 (en) 2000-05-31 2003-05-13 Grieshaber & Co. Ag Schaffhausen Device for use in a surgical procedure on an eye of a living being, and method of retracting the iris
AU2001268253A1 (en) 2000-06-19 2002-01-02 Glaukos Corporation Stented trabecular shunt and methods thereof
US6582453B1 (en) 2000-07-14 2003-06-24 Opus Medical, Inc. Method and apparatus for attaching connective tissues to bone using a suture anchoring device
US6629992B2 (en) 2000-08-04 2003-10-07 Advanced Cardiovascular Systems, Inc. Sheath for self-expanding stent
US6699211B2 (en) 2000-08-22 2004-03-02 James A. Savage Method and apparatus for treatment of glaucoma
DE10042310A1 (en) 2000-08-29 2002-03-14 Aixmed Ges Fuer Medizintechnik Aqueous humor drainage device
FR2813521B1 (en) 2000-09-01 2003-06-13 Ioltechnologie Production GLAUCOME DRAIN
US6428501B1 (en) 2000-09-19 2002-08-06 K2 Limited Partnership U/A/D Surgical instrument sleeve
US6730056B1 (en) 2000-09-21 2004-05-04 Motorola, Inc. Eye implant for treating glaucoma and method for manufacturing same
US6962573B1 (en) 2000-10-18 2005-11-08 Wilcox Michael J C-shaped cross section tubular ophthalmic implant for reduction of intraocular pressure in glaucomatous eyes and method of use
US6428566B1 (en) 2000-10-31 2002-08-06 Advanced Cardiovascular Systems, Inc. Flexible hoop and link sheath for a stent delivery system
WO2002036052A1 (en) 2000-11-01 2002-05-10 Glaukos Corporation Glaucoma treatment device
FR2817912B1 (en) 2000-12-07 2003-01-17 Hispano Suiza Sa REDUCER TAKING OVER THE AXIAL EFFORTS GENERATED BY THE BLOWER OF A TURBO-JET
DE10062478A1 (en) 2000-12-14 2002-07-04 Glautec Ag Glaucoma treatment device
US6544208B2 (en) 2000-12-29 2003-04-08 C. Ross Ethier Implantable shunt device
US6881198B2 (en) 2001-01-09 2005-04-19 J. David Brown Glaucoma treatment device and method
US6595945B2 (en) * 2001-01-09 2003-07-22 J. David Brown Glaucoma treatment device and method
DE10200617A1 (en) 2001-01-17 2002-07-18 Humanoptics Ag Implant for determining pressure of fluid in the eye chamber, has transceiver for transmitting measurement values to corresponding data processor transceiver to permit continuous pressure measurement
EP2335660B1 (en) 2001-01-18 2018-03-28 The Regents of The University of California Minimally invasive glaucoma surgical instrument
US6827738B2 (en) 2001-01-30 2004-12-07 Timothy R. Willis Refractive intraocular implant lens and method
ATE337766T1 (en) 2001-02-23 2006-09-15 Refocus Ocular Inc CUTTING DEVICE FOR SCLEROTIC IMPLANTS
DE60238665D1 (en) 2001-02-27 2011-02-03 Senju Pharma Co DRUG RELIEF SYSTEM FROM A BIODEGRADABLE POLYMER
JP2004525695A (en) 2001-03-16 2004-08-26 グローコス コーポレーション Applicator and method for positioning trabecular shunt for glaucoma treatment
US6585753B2 (en) 2001-03-28 2003-07-01 Scimed Life Systems, Inc. Expandable coil stent
US6981958B1 (en) 2001-05-02 2006-01-03 Glaukos Corporation Implant with pressure sensor for glaucoma treatment
US6666841B2 (en) 2001-05-02 2003-12-23 Glaukos Corporation Bifurcatable trabecular shunt for glaucoma treatment
US7431710B2 (en) 2002-04-08 2008-10-07 Glaukos Corporation Ocular implants with anchors and methods thereof
US7488303B1 (en) 2002-09-21 2009-02-10 Glaukos Corporation Ocular implant with anchor and multiple openings
DE10118933A1 (en) 2001-04-18 2002-11-14 Glautec Ag Glaucoma treatment device
AT409586B (en) 2001-04-26 2002-09-25 Clemens Dr Vass Implant draining aqueous humor from anterior chamber of eye into Schlemm's channel, includes fixation plate for stabilization on sclera
WO2002102274A2 (en) 2001-05-01 2002-12-27 Glaukos Corporation Glaucoma device and methods thereof
US7678065B2 (en) 2001-05-02 2010-03-16 Glaukos Corporation Implant with intraocular pressure sensor for glaucoma treatment
US6533769B2 (en) 2001-05-03 2003-03-18 Holmen Joergen Method for use in cataract surgery
AU2002305400A1 (en) 2001-05-03 2002-11-18 Glaukos Corporation Medical device and methods of use for glaucoma treatment
US6547993B1 (en) * 2001-05-09 2003-04-15 The United States Of America As Represented By The Secretary Of The Navy Process for making polytetrafluoroethylene-aluminum composite and product made
DE10127666A1 (en) 2001-06-07 2003-01-09 Glautec Ag Apparatus for glaucoma treatment by means of a laser catheter includes a stent made of a material which dissolves after a certain time
US7592016B2 (en) 2001-06-28 2009-09-22 Regents Of The University Of California Methods for preparing and using implantable substance delivery devices
US8267995B2 (en) 2001-08-03 2012-09-18 David Castillejos Method and intra sclera implant for treatment of glaucoma and presbyopia
RU2197206C1 (en) 2001-08-15 2003-01-27 Свадовский Александр Игоревич Method for treating the cases of glaucoma
CA2457137A1 (en) 2001-08-16 2003-02-27 Gmp Vision Solutions, Inc. Improved shunt device and method for treating glaucoma
US7331984B2 (en) * 2001-08-28 2008-02-19 Glaukos Corporation Glaucoma stent for treating glaucoma and methods of use
IN2014DN10834A (en) 2001-09-17 2015-09-04 Psivida Inc
US6767346B2 (en) 2001-09-20 2004-07-27 Endocare, Inc. Cryosurgical probe with bellows shaft
US20030097151A1 (en) * 2001-10-25 2003-05-22 Smedley Gregory T. Apparatus and mitochondrial treatment for glaucoma
US7163543B2 (en) 2001-11-08 2007-01-16 Glaukos Corporation Combined treatment for cataract and glaucoma treatment
US20030093084A1 (en) 2001-11-13 2003-05-15 Optonol Ltd. Delivery devices for flow regulating implants
EP1448124A1 (en) 2001-11-15 2004-08-25 Optotech Ltd. Non-penetrating filtration surgery
US6802829B2 (en) 2001-11-16 2004-10-12 Infinite Vision, Llc Spray device
US8491549B2 (en) 2001-11-21 2013-07-23 Iscience Interventional Corporation Ophthalmic microsurgical system
EP1810645B1 (en) 2001-11-22 2010-07-28 Eduard Anton Haefliger Device and method for performing ophthalmologic operations
US20030105456A1 (en) 2001-12-04 2003-06-05 J.T. Lin Apparatus and methods for prevention of age-related macular degeneration and other eye diseases
US6893413B2 (en) 2002-01-07 2005-05-17 Eric C. Martin Two-piece stent combination for percutaneous arterialization of the coronary sinus and retrograde perfusion of the myocardium
US6966888B2 (en) 2002-01-13 2005-11-22 Eagle Vision, Inc. Sinus valved glaucoma shunt
US20030153863A1 (en) 2002-02-13 2003-08-14 Patel Anilbhai S. Implant system for glaucoma surgery
US6589216B1 (en) * 2002-02-20 2003-07-08 Abbott Research Group, Inc. Vaginal douches, vaginal douche applicators and methods of vaginal douching
WO2003073968A2 (en) 2002-02-28 2003-09-12 Gmp Vision Solutions, Inc. Device and method for monitoring aqueous flow within the eye
US20060200113A1 (en) * 2002-03-07 2006-09-07 David Haffner Liquid jet for glaucoma treatment
US7186232B1 (en) 2002-03-07 2007-03-06 Glaukoa Corporation Fluid infusion methods for glaucoma treatment
US7951155B2 (en) 2002-03-15 2011-05-31 Glaukos Corporation Combined treatment for cataract and glaucoma treatment
US20030229303A1 (en) 2002-03-22 2003-12-11 Haffner David S. Expandable glaucoma implant and methods of use
US6902577B2 (en) 2002-03-29 2005-06-07 Isaac Lipshitz Intraocular lens implant with mirror
US9301875B2 (en) * 2002-04-08 2016-04-05 Glaukos Corporation Ocular disorder treatment implants with multiple opening
US20040147870A1 (en) * 2002-04-08 2004-07-29 Burns Thomas W. Glaucoma treatment kit
US20030195438A1 (en) 2002-04-12 2003-10-16 Petillo Phillip J. Method and apparatus to treat glaucoma
US20040024345A1 (en) * 2002-04-19 2004-02-05 Morteza Gharib Glaucoma implant with valveless flow bias
US7041114B2 (en) 2002-05-01 2006-05-09 D.O.T. Dan Ophthalmic Technologies Ltd. Surgical tool and method for extracting tissue from wall of an organ
AU2003241530A1 (en) 2002-05-20 2003-12-12 Refocus Group, Inc. System and method for determining a position for a scleral pocket for a scleral prosthesis
CA2487733C (en) 2002-05-29 2011-07-05 University Of Saskatchewan Technologies Inc. A shunt and method treatment of glaucoma
EP1932484B1 (en) 2002-06-11 2011-04-27 Tyco Healthcare Group LP Hernia mesh tacks
US20040243227A1 (en) 2002-06-13 2004-12-02 Guided Delivery Systems, Inc. Delivery devices and methods for heart valve repair
US20030236483A1 (en) 2002-06-25 2003-12-25 Ren David H Dual drainage ocular shunt for glaucoma
CN100591372C (en) * 2002-07-19 2010-02-24 耶鲁大学 Uveoscleral drainage device
US20070219632A1 (en) 2002-08-02 2007-09-20 David Castillejos Method and intra-sclera implant for treatment of glaucoma and presbyopia
US7192412B1 (en) * 2002-09-14 2007-03-20 Glaukos Corporation Targeted stent placement and multi-stent therapy
WO2004026347A2 (en) 2002-09-17 2004-04-01 Iscience Surgical Corporation Apparatus and method for surgical bypass of aqueous humor
JP3688287B1 (en) 2002-09-18 2005-08-24 アラーガン、インコーポレイテッド Device for delivering an ophthalmic implant
US7468065B2 (en) 2002-09-18 2008-12-23 Allergan, Inc. Apparatus for delivery of ocular implants
USRE40722E1 (en) 2002-09-27 2009-06-09 Surmodics, Inc. Method and apparatus for coating of substrates
US7192484B2 (en) 2002-09-27 2007-03-20 Surmodics, Inc. Advanced coating apparatus and method
US20040076868A1 (en) 2002-10-18 2004-04-22 Peter Mardilovich Fuel cell and method for forming
AU2003291377A1 (en) * 2002-11-06 2004-06-03 Gmp Vision Solutions, Inc. Storage apparatus for surgical implant device
US7001426B2 (en) 2002-11-18 2006-02-21 The Institute For Eye Research One-piece minicapsulorhexis valve
US7160264B2 (en) 2002-12-19 2007-01-09 Medtronic-Xomed, Inc. Article and method for ocular aqueous drainage
US7544368B2 (en) 2002-12-20 2009-06-09 Life Spring Biotech Co., Ltd. Structure for modulating intraocular pressure
JP2004208898A (en) 2002-12-27 2004-07-29 Japan Science & Technology Agency Hydatoid discharging implant for glaucoma treatment
US20040162545A1 (en) 2003-02-14 2004-08-19 Brown J. David Bypass for glaucoma drainage device
US8012115B2 (en) 2003-02-18 2011-09-06 S.K. Pharmaceuticals, Inc. Optic nerve implants
RU2361552C2 (en) 2003-02-18 2009-07-20 Хампар КАРАГЕОЗЯН Ways and devices for drainage of liquids and ophthalmotonus pressure dropping
US7297154B2 (en) 2003-02-24 2007-11-20 Maxwell Sensors Inc. Optical apparatus for detecting and treating vulnerable plaque
USD490152S1 (en) 2003-02-28 2004-05-18 Glaukos Corporation Surgical handpiece
US20050209672A1 (en) 2004-03-02 2005-09-22 Cardiomind, Inc. Sliding restraint stent delivery systems
US20040193262A1 (en) 2003-03-29 2004-09-30 Shadduck John H. Implants for treating ocular hypertension, methods of use and methods of fabrication
US20040193095A1 (en) 2003-03-29 2004-09-30 Shadduck John H. Implants for treating ocular hypertension, methods of use and methods of fabrication
US20070073275A1 (en) 2003-04-16 2007-03-29 Conston Stanley R Ophthalmic microsurgical instruments
US20050038498A1 (en) 2003-04-17 2005-02-17 Nanosys, Inc. Medical device applications of nanostructured surfaces
US7025740B2 (en) 2003-04-22 2006-04-11 Ahmed A Mateen Device for treating glaucoma & method of manufacture
US20040225250A1 (en) * 2003-05-05 2004-11-11 Michael Yablonski Internal shunt and method for treating glaucoma
US20040236343A1 (en) 2003-05-23 2004-11-25 Taylor Jon B. Insertion tool for ocular implant and method for using same
ES2386994T3 (en) 2003-06-10 2012-09-10 Neomedix Corporation Tubular cutting device
CA2528060C (en) 2003-06-10 2012-12-11 Neomedix Corporation Device and methods useable for treatment of glaucoma and other surgical procedures
US7670362B2 (en) 2003-06-13 2010-03-02 Tyco Healthcare Group Lp Multiple member interconnect for surgical instrument and absorbable screw fastener
US20060069340A1 (en) 2003-06-16 2006-03-30 Solx, Inc. Shunt for the treatment of glaucoma
CA2529495C (en) 2003-06-16 2013-02-05 Solx, Inc. Shunt for the treatment of glaucoma
US20050055075A1 (en) 2003-09-08 2005-03-10 Leonard Pinchuk Methods for the manufacture of porous prostheses
US7291125B2 (en) 2003-11-14 2007-11-06 Transcend Medical, Inc. Ocular pressure regulation
AU2004296205B2 (en) 2003-12-05 2009-11-12 Innfocus, Llc Glaucoma implant device
US20070149927A1 (en) 2003-12-15 2007-06-28 Terumo Kabushiki Kaisha Catheter assembly
CA2552966C (en) 2004-01-12 2012-10-30 Iscience Surgical Corporation Injector for viscous materials
WO2005072294A2 (en) 2004-01-22 2005-08-11 Solx, Inc. Glaucoma treatment method
EP1715827B1 (en) 2004-01-23 2010-12-29 iScience Interventional Corporation Composite ophthalmic microcannula
US20050250788A1 (en) * 2004-01-30 2005-11-10 Hosheng Tu Aqueous outflow enhancement with vasodilated aqueous cavity
US20060036207A1 (en) 2004-02-24 2006-02-16 Koonmen James P System and method for treating glaucoma
US7364564B2 (en) 2004-03-02 2008-04-29 Becton, Dickinson And Company Implant having MEMS flow module with movable, flow-controlling baffle
US7544176B2 (en) 2005-06-21 2009-06-09 Becton, Dickinson And Company Glaucoma implant having MEMS flow module with flexing diaphragm for pressure regulation
US7384550B2 (en) 2004-02-24 2008-06-10 Becton, Dickinson And Company Glaucoma implant having MEMS filter module
US7803150B2 (en) 2004-04-21 2010-09-28 Acclarent, Inc. Devices, systems and methods useable for treating sinusitis
US7156821B2 (en) 2004-04-23 2007-01-02 Massachusetts Eye & Ear Infirmary Shunt with enclosed pressure-relief valve
US8114099B2 (en) 2004-04-27 2012-02-14 Tyco Healthcare Group Lp Absorbable anchor for hernia mesh fixation
US7758612B2 (en) 2004-04-27 2010-07-20 Tyco Healthcare Group Lp Surgery delivery device and mesh anchor
KR20070036044A (en) 2004-04-29 2007-04-02 아이싸이언스 인터벤셔날 코포레이션 Apparatus and method for ocular treatment
US20090043321A1 (en) 2004-04-29 2009-02-12 Iscience Interventional Corporation Apparatus And Method For Surgical Enhancement Of Aqueous Humor Drainage
US20100173866A1 (en) * 2004-04-29 2010-07-08 Iscience Interventional Corporation Apparatus and method for ocular treatment
US20080058704A1 (en) * 2004-04-29 2008-03-06 Michael Hee Apparatus and Method for Ocular Treatment
US8673341B2 (en) 2004-04-30 2014-03-18 Allergan, Inc. Intraocular pressure reduction with intracameral bimatoprost implants
AU2005253930B2 (en) 2004-05-11 2011-04-28 Oregon Health And Science University Interfacial stent and method of maintaining patency of surgical fenestrations
US7357778B2 (en) 2004-05-20 2008-04-15 Ajay Bhalla Aqueous drainage and flow regulating implant
EP1786489A2 (en) 2004-05-27 2007-05-23 Clarity Corporation Glaucoma shunt
US20050283108A1 (en) 2004-06-10 2005-12-22 Savage James A Apparatus and method for non-pharmacological treatment of glaucoma and lowering intraocular pressure
US20060293612A1 (en) 2004-06-24 2006-12-28 Boston Scientific Scimed, Inc. Apparatus and method for treating occluded vasculature
US7862531B2 (en) 2004-06-25 2011-01-04 Optonol Ltd. Flow regulating implants
US20060032507A1 (en) * 2004-08-11 2006-02-16 Hosheng Tu Contrast-enhanced ocular imaging
US8246569B1 (en) 2004-08-17 2012-08-21 California Institute Of Technology Implantable intraocular pressure drain
US20060069350A1 (en) * 2004-09-30 2006-03-30 Buenger David R Medical syringe injector pen
US7905904B2 (en) 2006-02-03 2011-03-15 Biomet Sports Medicine, Llc Soft tissue repair device and associated methods
US20060173397A1 (en) * 2004-11-23 2006-08-03 Hosheng Tu Ophthalmology implants and methods of manufacture
US7594899B2 (en) 2004-12-03 2009-09-29 Innfocus, Llc Glaucoma implant device
US7837644B2 (en) 2004-12-03 2010-11-23 Innfocus, Llc Glaucoma implant device
US20070118065A1 (en) 2004-12-03 2007-05-24 Leonard Pinchuk Glaucoma Implant Device
US20060129129A1 (en) 2004-12-10 2006-06-15 Cloud Farm Associates, L.P. Eye implant devices and method and device for implanting such devices for treatment of glaucoma
CA2592459C (en) 2004-12-16 2017-08-22 Iscience Interventional Corporation Ophthalmic implant for treatment of glaucoma
US20120010702A1 (en) 2004-12-16 2012-01-12 Iscience Interventional Corporation Ophthalmic implant for treatment of glaucoma
US7713228B2 (en) 2005-01-28 2010-05-11 Alcon, Inc. Surgical method
AR054647A1 (en) 2005-02-21 2007-07-11 Maldonado Bas Arturo DEVICE FOR WATER HUMOR DRAINAGE IN GLAUCOMA CASES
US9186274B2 (en) 2005-02-23 2015-11-17 Camras Vision Inc. Method and apparatus for reducing intraocular pressure
CA2598696A1 (en) 2005-02-23 2006-08-31 Surmodics, Inc. Implantable medical articles having laminin coatings and methods of use
US7641627B2 (en) 2005-02-23 2010-01-05 Camras Carl B Method and apparatus for reducing intraocular pressure
US20060217741A1 (en) 2005-03-28 2006-09-28 Ghannoum Ziad R Irrigation tip
US20080269730A1 (en) 2005-04-14 2008-10-30 Dotson Robert S Ophthalmic Phototherapy Device and Associated Treatment Method
US20130079759A1 (en) 2005-04-14 2013-03-28 Robert S. Dotson Ophthalmic Phototherapy Device and Associated Treatment Method
JP2008539965A (en) 2005-05-10 2008-11-20 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア Self-cleaning catheter for clinical transplantation
WO2006121066A1 (en) 2005-05-10 2006-11-16 Takuya Kataoka Ophthalmologic laser treatment instrument
US20070021653A1 (en) 2005-06-27 2007-01-25 Lars-Olof Hattenbach Device for the injection of drugs into microvessels
US20090043365A1 (en) 2005-07-18 2009-02-12 Kolis Scientific, Inc. Methods, apparatuses, and systems for reducing intraocular pressure as a means of preventing or treating open-angle glaucoma
US20080108932A1 (en) 2005-08-24 2008-05-08 Rodgers M Steven MEMS filter module with multi-level filter traps
JP2009508584A (en) 2005-09-16 2009-03-05 ビージー インプラント インコーポレイテッド Glaucoma treatment apparatus and method
US20070073390A1 (en) 2005-09-23 2007-03-29 Medlogics Device Corporation Methods and devices for enhanced adhesion between metallic substrates and bioactive material-containing coatings
EP1940316B1 (en) 2005-09-26 2015-10-21 AttenueX Technologies, Inc. Pressure attenuation device
US7717872B2 (en) 2005-09-28 2010-05-18 Rajesh Kumar Shetty Fluid shunting apparatus and methods
US7771388B2 (en) 2005-10-12 2010-08-10 Daniel Olsen Steerable catheter system
US7655831B2 (en) 2005-10-19 2010-02-02 Prywes Arnold S Method for fluid control in medical applications
US7959632B2 (en) 2005-10-20 2011-06-14 Fugo Richard J Plasma incising device including disposable incising tips for performing surgical procedures
TW200733993A (en) 2005-11-03 2007-09-16 Reseal Internat Ltd Partnership Continuously sealing one way valve assembly and fluid delivery system and formulations for use therein
US20070106200A1 (en) 2005-11-08 2007-05-10 Brian Levy Intraocular shunt device and method
WO2007062306A2 (en) 2005-11-18 2007-05-31 The Board Of Regents Of The University Of Texas System Methods for coating surfaces with antimicrobial agents
US20070161981A1 (en) 2006-01-06 2007-07-12 Arthrocare Corporation Electrosurgical method and systems for treating glaucoma
US9084662B2 (en) * 2006-01-17 2015-07-21 Transcend Medical, Inc. Drug delivery treatment device
ES2762239T3 (en) 2006-01-17 2020-05-22 Alcon Inc Glaucoma treatment device
US20070202186A1 (en) * 2006-02-22 2007-08-30 Iscience Interventional Corporation Apparatus and formulations for suprachoroidal drug delivery
US8585753B2 (en) 2006-03-04 2013-11-19 John James Scanlon Fibrillated biodegradable prosthesis
EP1832301A3 (en) 2006-03-08 2007-12-05 Sahajanand Medical Technologies PVT. ltd Coatings for implantable medical devices
WO2007121485A2 (en) * 2006-04-18 2007-10-25 Cascade Ophthalmics Intraocular pressure attenuation device
US7520876B2 (en) 2006-04-21 2009-04-21 Entellus Medical, Inc. Device and method for treatment of sinusitis
US20080039931A1 (en) 2006-04-25 2008-02-14 Surmodics, Inc. Hydrophilic shape memory insertable medical articles
US9381301B2 (en) 2006-04-26 2016-07-05 Eastern Virginia Medical School Systems and methods for monitoring and controlling internal pressure of an eye or body part
US20070293807A1 (en) 2006-05-01 2007-12-20 Lynch Mary G Dual drainage pathway shunt device and method for treating glaucoma
US7918814B2 (en) 2006-05-02 2011-04-05 Georgia Tech Research Corporation Method for drug delivery to ocular tissue using microneedle
US20070292470A1 (en) 2006-06-15 2007-12-20 Medtronic Vascular, Inc. Implantable Medical Devices and Methods for Making the Same
US20070293873A1 (en) 2006-06-19 2007-12-20 Allergan, Inc. Apparatus and methods for implanting particulate ocular implants
US8668676B2 (en) 2006-06-19 2014-03-11 Allergan, Inc. Apparatus and methods for implanting particulate ocular implants
US7458953B2 (en) 2006-06-20 2008-12-02 Gholam A. Peyman Ocular drainage device
US7909789B2 (en) 2006-06-26 2011-03-22 Sight Sciences, Inc. Intraocular implants and methods and kits therefor
US20120197175A1 (en) 2006-06-30 2012-08-02 Aquesys, Inc. Methods, systems and apparatus for relieving pressure in an organ
US8758290B2 (en) 2010-11-15 2014-06-24 Aquesys, Inc. Devices and methods for implanting a shunt in the suprachoroidal space
US8721702B2 (en) 2010-11-15 2014-05-13 Aquesys, Inc. Intraocular shunt deployment devices
US20080108933A1 (en) 2006-06-30 2008-05-08 Dao-Yi Yu Methods, Systems and Apparatus for Relieving Pressure in an Organ
US8852137B2 (en) 2010-11-15 2014-10-07 Aquesys, Inc. Methods for implanting a soft gel shunt in the suprachoroidal space
US8663303B2 (en) 2010-11-15 2014-03-04 Aquesys, Inc. Methods for deploying an intraocular shunt from a deployment device and into an eye
AU2007273119A1 (en) 2006-07-07 2008-01-17 Surmodics, Inc. Implantable medical articles having pro-healing coatings
EP2526909B1 (en) 2006-07-11 2020-06-24 Refocus Group, Inc. Apparatus for securing ocular tissue
US9039761B2 (en) 2006-08-04 2015-05-26 Allergan, Inc. Ocular implant delivery assemblies with distal caps
WO2008022048A2 (en) 2006-08-10 2008-02-21 California Institute Of Technology Microfluidic valve having free-floating member and method of fabrication
US20100262174A1 (en) 2006-08-11 2010-10-14 The Regents Of The University Of California Microsurgery for Treatment of Glaucoma
US8043235B2 (en) 2006-08-22 2011-10-25 Schwartz Donald N Ultrasonic treatment of glaucoma
US7909781B2 (en) 2006-08-22 2011-03-22 Schwartz Donald N Ultrasonic treatment of glaucoma
US20080097214A1 (en) 2006-09-05 2008-04-24 Capistrano Labs, Inc. Ophthalmic ultrasound probe assembly
EP2059282A4 (en) 2006-09-06 2014-04-09 Innfocus Inc Apparatus, methods and devices for treatment of ocular disorders
US20080109037A1 (en) 2006-11-03 2008-05-08 Musculoskeletal Transplant Foundation Press fit suture anchor and inserter assembly
US20080147083A1 (en) 2006-11-09 2008-06-19 Vold Steven D Method and device for fixation of ophthalmic tissue
JP5748407B2 (en) * 2006-11-10 2015-07-15 グローコス コーポレーション Uveal sclera shunt
US20080114440A1 (en) 2006-11-13 2008-05-15 Sage Medical Technologies, Inc Methods and devices for deploying an implant in curved anatomy
US20080147168A1 (en) 2006-12-04 2008-06-19 Terrance Ransbury Intravascular implantable device having detachable tether arrangement
FR2909883B1 (en) 2006-12-18 2012-11-30 Commissariat Energie Atomique MULTI-ARM SENSOR AND SYSTEM FOR DEEP ELECTRICAL NEUROSTIMULATION COMPRISING SUCH A PROBE
WO2008083118A1 (en) 2006-12-26 2008-07-10 Qlt Plug Delivery, Inc. Drug delivery implants for inhibition of optical defects
AR058947A1 (en) 2007-01-08 2008-03-05 Consejo Nac Invest Cient Tec IMPLANTABLE MICROAPARATE IN THE EYE TO RELIEF GLAUCOMA OR CAUSING DISEASE OF EYE OVERPRESSION
US20080200923A1 (en) 2007-01-09 2008-08-21 Richard Beckman Insertion tool for ocular implant and method for using same
EP2124857B1 (en) 2007-01-09 2017-03-29 Fovea Pharmaceuticals Apparatus for intra-ocular injection
DE102007004906A1 (en) 2007-01-25 2008-07-31 Universität Rostock eye implant
US8066768B2 (en) 2007-01-29 2011-11-29 Werblin Research & Development Corp. Intraocular lens system
US20080188860A1 (en) 2007-02-07 2008-08-07 Vold Steven D Ophthalmic surgical apparatus
WO2008096821A1 (en) 2007-02-08 2008-08-14 Kaneka Corporation Injector for eye
USD606190S1 (en) 2007-02-08 2009-12-15 Aderans Research Institute, Inc. Device for delivering cellular material and physiologic fluids to a subject
US20080208176A1 (en) 2007-02-27 2008-08-28 Ih-Houng Loh Instrument for injecting an ophthalmic device into an eye
WO2008112935A1 (en) 2007-03-13 2008-09-18 University Of Rochester Intraocular pressure regulating device
US20080243247A1 (en) 2007-03-26 2008-10-02 Poley Brooks J Method and apparatus for prevention and treatment of adult glaucoma
US20080243156A1 (en) 2007-03-30 2008-10-02 Thomas John Ophthalmic surgical instrument & surgical methods
US20080255545A1 (en) 2007-04-10 2008-10-16 Mansfield John M Apparatus and method for treating the inside of an eye
US7931660B2 (en) 2007-05-10 2011-04-26 Tyco Healthcare Group Lp Powered tacker instrument
WO2008154502A1 (en) * 2007-06-07 2008-12-18 Yale University Uveoscleral drainage device
WO2008151328A2 (en) 2007-06-08 2008-12-11 Cornell University Microprobes
EP2173289A4 (en) 2007-07-17 2010-11-24 Transcend Medical Inc Ocular implant with hydrogel expansion capabilities
US20090043242A1 (en) 2007-08-07 2009-02-12 Becton, Dickinson And Company Instruments and methods for implanting corneal implant via extra-and intra-cameral routes
JP5524841B2 (en) 2007-09-07 2014-06-18 キュー エル ティー インク. Lacrimal implant and related methods
US7740604B2 (en) 2007-09-24 2010-06-22 Ivantis, Inc. Ocular implants for placement in schlemm's canal
US8734377B2 (en) 2007-09-24 2014-05-27 Ivantis, Inc. Ocular implants with asymmetric flexibility
US20090082862A1 (en) 2007-09-24 2009-03-26 Schieber Andrew T Ocular Implant Architectures
US8945103B2 (en) 2007-10-30 2015-02-03 Iridex Corporation Contact probe for the delivery of laser energy
US8083759B2 (en) 2007-11-02 2011-12-27 Refocus Ocular, Inc. Apparatuses and methods for forming incisions in ocular tissue
US20090177138A1 (en) 2007-11-07 2009-07-09 Brown Reay H Shunt Device for Glaucoma Treatment
US9849027B2 (en) 2007-11-08 2017-12-26 Alimera Sciences, Inc. Ocular implantation device
USD592746S1 (en) 2007-11-08 2009-05-19 Alimera Sciences Ocular implantation device
US20090124973A1 (en) 2007-11-09 2009-05-14 D Agostino Eduardo Insertion mechanism for use with a syringe
US8512404B2 (en) 2007-11-20 2013-08-20 Ivantis, Inc. Ocular implant delivery system and method
US9375347B2 (en) 2007-11-23 2016-06-28 Ecole Polytechnique Federale De Lausanne (Epfl) Non-invasively adjustable drainage device
US20090137992A1 (en) 2007-11-27 2009-05-28 Ravi Nallakrishnan Apparatus and Method for Treating Glaucoma
US8583242B2 (en) 2008-01-04 2013-11-12 Doheny Eye Institute Subchoroidal retinal prosthesis
EP3108933B1 (en) 2008-01-07 2019-09-18 Salutaris Medical Devices, Inc. Devices for minimally-invasive extraocular delivery of radiation to the posterior portion of the eye
US9539138B2 (en) 2008-01-30 2017-01-10 Takaya TANAKA Method of ophthalmic surgery and kit therefor
US8109896B2 (en) 2008-02-11 2012-02-07 Optonol Ltd. Devices and methods for opening fluid passageways
JP2011513002A (en) 2008-03-05 2011-04-28 イバンティス インコーポレイテッド Method and apparatus for treating glaucoma
US20110082385A1 (en) 2008-04-17 2011-04-07 Yale University Method for implanting intraocular pressure sensor
US20090287233A1 (en) 2008-05-15 2009-11-19 Huculak John C Small Gauge Mechanical Tissue Cutter/Aspirator Probe For Glaucoma Surgery
EP2291155B1 (en) 2008-05-15 2013-08-28 Mynosys Cellular Devices, Inc. Ophthalmic surgical device for capsulotomy
US8157759B2 (en) 2008-05-16 2012-04-17 Ocumatrix, Inc. Method and apparatus for fluid drainage of the eye
US8702995B2 (en) 2008-05-27 2014-04-22 Dober Chemical Corp. Controlled release of microbiocides
ES2640867T3 (en) 2008-06-25 2017-11-07 Novartis Ag Eye implant with ability to change shape
US8628492B2 (en) 2008-07-01 2014-01-14 California Institute Of Technology Implantable glaucoma drainage device
TW201006453A (en) 2008-07-08 2010-02-16 Qlt Plug Delivery Inc Lacrimal implant body including comforting agent
US20100056977A1 (en) 2008-08-26 2010-03-04 Thaddeus Wandel Trans-corneal shunt and method
US8353856B2 (en) 2008-11-05 2013-01-15 Abbott Medical Optics Inc. Glaucoma drainage shunts and methods of use
US7695135B1 (en) 2008-11-11 2010-04-13 Boston Foundation For Sight Scleral lens with scalloped channels or circumferential fenestrated channels
US8079972B2 (en) 2008-11-20 2011-12-20 Schocket Stanley S Implant for use in surgery for glaucoma and a method
CN102238926B (en) 2008-12-05 2015-09-16 伊万提斯公司 For ocular implants being transported to the method and apparatus in eyes
US20100158980A1 (en) 2008-12-18 2010-06-24 Casey Kopczynski Drug delivery devices for delivery of therapeutic agents
CH700161A2 (en) 2008-12-22 2010-06-30 Grieshaber Ophthalmic Res Foun IMPLANT FOR INTRODUCING into Schlemm's canal AN EYE.
CA2750178A1 (en) 2009-01-02 2010-07-08 Alan L. Weiner In-situ refillable ophthalmic implant
US8545554B2 (en) 2009-01-16 2013-10-01 Allergan, Inc. Intraocular injector
EP2548538B1 (en) 2009-01-28 2020-04-01 Alcon Inc. Implantation systems for ocular implants with stiffness qualities
CN102365109B (en) 2009-01-29 2015-06-03 弗赛特影像4股份有限公司 Posterior segment drug delivery
WO2010093945A2 (en) 2009-02-13 2010-08-19 Glaukos Corporation Uveoscleral drug delivery implant and methods for implanting the same
US20100225061A1 (en) 2009-03-09 2010-09-09 Bath David L System and method for gaming with an engagable projectile
AU2010229789B2 (en) 2009-03-26 2014-11-13 Johnson & Johnson Surgical Vision, Inc. Glaucoma shunts with flow management and improved surgical performance
WO2010115101A1 (en) 2009-04-03 2010-10-07 Transcend Medical, Inc. Ocular implant delivery systems and methods
US10206813B2 (en) 2009-05-18 2019-02-19 Dose Medical Corporation Implants with controlled drug delivery features and methods of using same
EP4289416A3 (en) 2009-05-18 2024-01-03 Dose Medical Corporation Drug eluting ocular implant
US8764696B2 (en) 2009-06-16 2014-07-01 Mobius Therapeutics, Inc. Medical drainage devices with carbon-based structures for inhibiting growth of fibroblasts
AU2010271274B2 (en) 2009-07-09 2015-05-21 Alcon Inc. Single operator device for delivering an ocular implant
AU2010271218B2 (en) 2009-07-09 2017-02-02 Alcon Inc. Ocular implants and methods for delivering ocular implants into the eye
US20120130467A1 (en) 2009-07-24 2012-05-24 Selden Nathan R Interfacial stent and method of maintaining patency of surgical fenestrations
US8535333B2 (en) 2009-07-29 2013-09-17 Transcend Medical, Inc. Ocular implant applier and methods of use
US20110118835A1 (en) 2009-08-13 2011-05-19 Matthew Silvestrini Branched ocular implant
US8951221B2 (en) 2009-08-20 2015-02-10 Grieshaber Ophthalmic Research Foundation Method and device for the treatment of glaucoma
US8257295B2 (en) 2009-09-21 2012-09-04 Alcon Research, Ltd. Intraocular pressure sensor with external pressure compensation
US8419673B2 (en) 2009-09-21 2013-04-16 Alcon Research, Ltd. Glaucoma drainage device with pump
US8545431B2 (en) 2009-09-21 2013-10-01 Alcon Research, Ltd. Lumen clearing valve for glaucoma drainage device
EP2480186A1 (en) 2009-09-21 2012-08-01 Vidus Ocular, Inc. Uveoscleral drainage device
US8721580B2 (en) 2009-09-21 2014-05-13 Alcon Research, Ltd. Power saving glaucoma drainage device
US20110071454A1 (en) 2009-09-21 2011-03-24 Alcon Research, Ltd. Power Generator For Glaucoma Drainage Device
WO2011046949A2 (en) 2009-10-12 2011-04-21 The Regents Of The University Of Colorado, A Body Corporate Implants for reducing intraocular pressure
US9119951B2 (en) 2009-10-12 2015-09-01 Kona Medical, Inc. Energetic modulation of nerves
EP2490621A4 (en) 2009-10-23 2013-04-03 Ivantis Inc Ocular implant system and method
US8771216B2 (en) 2009-11-06 2014-07-08 University Hospitals Of Cleveland Fluid communication device and method of use thereof
US8845572B2 (en) 2009-11-13 2014-09-30 Grieshaber Ophthalmic Research Foundation Method and device for the treatment of glaucoma
US8372423B2 (en) 2009-11-25 2013-02-12 Healionics Corporation Implantable medical devices having microporous surface layers and method for reducing foreign body response to the same
US20110144641A1 (en) 2009-12-15 2011-06-16 Alcon Research, Ltd. High-Intensity Pulsed Electric Field Vitrectomy Apparatus
US8529622B2 (en) 2010-02-05 2013-09-10 Sight Sciences, Inc. Intraocular implants and related kits and methods
US20110202049A1 (en) 2010-02-18 2011-08-18 Alcon Research, Ltd. Small Gauge Ablation Probe For Glaucoma Surgery
US20110230877A1 (en) 2010-03-16 2011-09-22 Alcon Research, Ltd. Pulsed Electric Field Probe for Glaucoma Surgery
US20110245753A1 (en) 2010-04-05 2011-10-06 Sunalp Murad A Apparatus and method for lowering intraocular pressure in an eye
US20110248671A1 (en) 2010-04-08 2011-10-13 Alcon Research, Ltd. Power System Implantable in Eye
PT2575715E (en) 2010-05-27 2014-12-22 Ellex Iscience Inc Device for placing circumferential implant in schlemm's canal
US8444589B2 (en) 2010-06-09 2013-05-21 Transcend Medical, Inc. Ocular implant with fluid outflow pathways having microporous membranes
US8545430B2 (en) 2010-06-09 2013-10-01 Transcend Medical, Inc. Expandable ocular devices
WO2011163505A1 (en) 2010-06-23 2011-12-29 Ivantis, Inc. Ocular implants deployed in schlemm's canal of the eye
WO2012006053A1 (en) 2010-06-29 2012-01-12 Kullervo Henrik Hynynen Thermal therapy apparatus and method using focused ultrasonic sound fields
US8821457B2 (en) 2010-09-08 2014-09-02 Johnson & Johnson Vision Care, Inc. Punctal plug containing drug formulation
US8449490B2 (en) 2010-09-11 2013-05-28 Aleeva Medical Inc. Disc shunt delivery with stepped needle
US8915877B2 (en) 2010-10-12 2014-12-23 Emmett T. Cunningham, JR. Glaucoma drainage device and uses thereof
US9370444B2 (en) 2010-10-12 2016-06-21 Emmett T. Cunningham, JR. Subconjunctival conformer device and uses thereof
EP2627292B1 (en) 2010-10-15 2018-10-10 Clearside Biomedical, Inc. Device for ocular access
US8585629B2 (en) 2010-11-15 2013-11-19 Aquesys, Inc. Systems for deploying intraocular shunts
US9668915B2 (en) 2010-11-24 2017-06-06 Dose Medical Corporation Drug eluting ocular implant
US20120238994A1 (en) 2010-12-22 2012-09-20 Martin Nazzaro Two-piece injectable drug delivery device with heat-cured seal
JP2014507978A (en) 2011-01-14 2014-04-03 エコール ポリテクニーク フェデラル ドゥ ローザンヌ ウペエフエル−テーテーオー Apparatus and method for treating excess intraocular fluid
WO2012099873A1 (en) 2011-01-18 2012-07-26 Minipums, Llc Surgical implantation instrument
EP2517619B1 (en) 2011-04-27 2013-05-22 Istar Medical Improvements in or relating to glaucoma management and treatment
US20120283557A1 (en) 2011-05-05 2012-11-08 Berlin Michael S Methods and Apparatuses for the Treatment of Glaucoma using visible and infrared ultrashort laser pulses
US8747299B2 (en) 2011-06-02 2014-06-10 Grieshaber Ophtalmic Research Foundation Method and device for the pathology analysis of the Schlemm's canal
US20120310137A1 (en) 2011-06-02 2012-12-06 Silvestrini Thomas A Eye shunt with porous structure
US8657776B2 (en) 2011-06-14 2014-02-25 Ivantis, Inc. Ocular implants for delivery into the eye
EP4193907A1 (en) 2011-09-13 2023-06-14 Glaukos Corporation Intraocular physiological sensor
US9072588B2 (en) 2011-10-03 2015-07-07 Alcon Research, Ltd. Selectable varied control valve systems for IOP control systems
US8585631B2 (en) 2011-10-18 2013-11-19 Alcon Research, Ltd. Active bimodal valve system for real-time IOP control
US8753305B2 (en) 2011-12-06 2014-06-17 Alcon Research, Ltd. Bubble-driven IOP control system
US8771220B2 (en) 2011-12-07 2014-07-08 Alcon Research, Ltd. Glaucoma active pressure regulation shunt
US8852136B2 (en) 2011-12-08 2014-10-07 Aquesys, Inc. Methods for placing a shunt into the intra-scleral space
US8579848B2 (en) 2011-12-09 2013-11-12 Alcon Research, Ltd. Active drainage systems with pressure-driven valves and electronically-driven pump
US8840578B2 (en) 2011-12-09 2014-09-23 Alcon Research, Ltd. Multilayer membrane actuators
US8603024B2 (en) 2011-12-12 2013-12-10 Alcon Research, Ltd. Glaucoma drainage devices including vario-stable valves and associated systems and methods
US20130150777A1 (en) 2011-12-12 2013-06-13 Sebastian Böhm Glaucoma Drainage Devices Including Vario-Stable Valves and Associated Systems and Methods
US8585664B2 (en) 2011-12-12 2013-11-19 Alcon Research, Ltd System and method for powering ocular implants
WO2013090231A1 (en) 2011-12-13 2013-06-20 Alcon Research, Ltd. Active drainage systems with dual-input pressure-driven valves
US9339187B2 (en) 2011-12-15 2016-05-17 Alcon Research, Ltd. External pressure measurement system and method for an intraocular implant
US8663150B2 (en) 2011-12-19 2014-03-04 Ivantis, Inc. Delivering ocular implants into the eye
US9101444B2 (en) 2012-01-12 2015-08-11 Innfocus, Inc. Method, surgical kit and device for treating glaucoma
EP2814555B1 (en) 2012-02-13 2017-09-27 Iridex Corporation Reduction of intraocular pressure in the eye using a tubular clip
US9155653B2 (en) 2012-02-14 2015-10-13 Alcon Research, Ltd. Pressure-driven membrane valve for pressure control system
US8986240B2 (en) 2012-02-14 2015-03-24 Alcon Research, Ltd. Corrugated membrane actuators
CA2868341C (en) 2012-03-26 2021-01-12 Glaukos Corporation System and method for delivering multiple ocular implants
US8998838B2 (en) 2012-03-29 2015-04-07 Alcon Research, Ltd. Adjustable valve for IOP control with reed valve
DK2854708T3 (en) 2012-06-04 2017-01-30 Alcon Pharmaceuticals Ltd DEVICE FOR INSTALLING AN INTRAOCULAR LENS AND PROCEDURE FOR EXTING AN INTRAOCULAR LENS FROM A PATTERN
US9308082B2 (en) 2012-08-07 2016-04-12 RegenEye, L.L.C. Ocular collar stent for treating narrowing of the irideocorneal angle
US8864701B2 (en) 2012-08-13 2014-10-21 Alcon Research, Ltd. Implantable MEMS device and method
US8956320B2 (en) 2012-08-28 2015-02-17 Alcon Research, Ltd. Capillary valve
US9132034B2 (en) 2012-10-01 2015-09-15 Alcon Research, Ltd. Valve position sensor
WO2014078288A1 (en) 2012-11-14 2014-05-22 Transcend Medical, Inc. Flow promoting ocular implant
WO2014145021A1 (en) 2013-03-15 2014-09-18 Orange County Glaucoma, Pc Enhancement of aqueous flow
US10517759B2 (en) 2013-03-15 2019-12-31 Glaukos Corporation Glaucoma stent and methods thereof for glaucoma treatment
US9592151B2 (en) 2013-03-15 2017-03-14 Glaukos Corporation Systems and methods for delivering an ocular implant to the suprachoroidal space within an eye
US9226851B2 (en) 2013-08-24 2016-01-05 Novartis Ag MEMS check valve chip and methods
US9283115B2 (en) 2013-08-26 2016-03-15 Novartis Ag Passive to active staged drainage device
US9289324B2 (en) 2013-08-26 2016-03-22 Novartis Ag Externally adjustable passive drainage device
WO2016011056A1 (en) * 2014-07-14 2016-01-21 Ivantis, Inc. Ocular implant delivery system and method
US20180369017A1 (en) * 2015-12-15 2018-12-27 Ivantis, Inc. Ocular implant and delivery system
EP3668460A4 (en) 2017-08-17 2021-05-05 Aspip Inc. Method, device, and system for treatment of elevated intraocular pressure

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11116625B2 (en) 2017-09-28 2021-09-14 Glaukos Corporation Apparatus and method for controlling placement of intraocular implants

Also Published As

Publication number Publication date
EP1418868A2 (en) 2004-05-19
US9987472B2 (en) 2018-06-05
AU2009251058B2 (en) 2013-08-22
US9572963B2 (en) 2017-02-21
JP2009056324A (en) 2009-03-19
US10828473B2 (en) 2020-11-10
WO2002080811A2 (en) 2002-10-17
DE60225815D1 (en) 2008-05-08
AU2006236060A1 (en) 2006-12-07
ATE390106T1 (en) 2008-04-15
EP2263621A1 (en) 2010-12-22
US8062244B2 (en) 2011-11-22
JP2013066742A (en) 2013-04-18
AU2009251058A1 (en) 2010-01-21
JP2016135275A (en) 2016-07-28
JP2005512607A (en) 2005-05-12
US20130281910A1 (en) 2013-10-24
DE60225815T2 (en) 2009-02-05
US20130245532A1 (en) 2013-09-19
US20080200860A1 (en) 2008-08-21
AU2002258754B2 (en) 2006-08-17
CA2683224C (en) 2014-12-02
US20070112292A1 (en) 2007-05-17
US20210154449A1 (en) 2021-05-27
JP6416815B2 (en) 2018-10-31
EP1418868A4 (en) 2006-11-22
CA2442652A1 (en) 2002-10-17
US7857782B2 (en) 2010-12-28
US20020188308A1 (en) 2002-12-12
US20110092878A1 (en) 2011-04-21
US8075511B2 (en) 2011-12-13
US8579846B2 (en) 2013-11-12
US20090138022A1 (en) 2009-05-28
AU2006236060B2 (en) 2009-09-24
JP4264704B2 (en) 2009-05-20
US20190030302A1 (en) 2019-01-31
EP2263621B1 (en) 2015-05-20
ES2304438T3 (en) 2008-10-16
US7135009B2 (en) 2006-11-14
US20120071809A1 (en) 2012-03-22
WO2002080811A3 (en) 2004-03-11
CA2442652C (en) 2011-01-04
EP1977724A1 (en) 2008-10-08
EP2982354A1 (en) 2016-02-10
EP1418868B1 (en) 2008-03-26
WO2002080811A9 (en) 2003-04-10
US7563241B2 (en) 2009-07-21
US20090143712A1 (en) 2009-06-04
JP5255402B2 (en) 2013-08-07

Similar Documents

Publication Publication Date Title
US20210154449A1 (en) Ocular implant delivery system and methods thereof
AU2002258754A1 (en) Glaucoma stent and methods thereof for glaucoma treatment
CA2530234A1 (en) Devices and methods for treating an ophthalmic condition
CA2718294C (en) Non-linear delivery device and ocular implant for lowering intraocular pressure
AU2011253668B2 (en) Devices and methods for glaucoma treatment
AU2011253665A1 (en) Devices and methods for glaucoma treatment

Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry

Effective date: 20220408