CA2571871C - Flow regulating implants - Google Patents
Flow regulating implants Download PDFInfo
- Publication number
- CA2571871C CA2571871C CA2571871A CA2571871A CA2571871C CA 2571871 C CA2571871 C CA 2571871C CA 2571871 A CA2571871 A CA 2571871A CA 2571871 A CA2571871 A CA 2571871A CA 2571871 C CA2571871 C CA 2571871C
- Authority
- CA
- Canada
- Prior art keywords
- implant
- elongated
- grooves
- parts
- flow
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/007—Methods or devices for eye surgery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/007—Methods or devices for eye surgery
- A61F9/00781—Apparatus for modifying intraocular pressure, e.g. for glaucoma treatment
Abstract
A flow regulating implant is provided with one or more grooves for allowing fluid flow. One or more grooves may have a constant or varying cross-section along its length. One or more grooves may have in it biodegradable material, absorbable material, and/or threads or sutures. A resilient band or coating may be placed around the implant or one or more grooves, to act as a pressure regulator. The implant may have a side projection, such as a side pin, for engaging tissue. The implant may comprise two or more parts that are held at a. distance from each other to allow fluid flow between the parts.
Description
FLOW REGULATING IMPLANTS
HELD OF THE INVENTION
[0001] The invention relates generally to flow regulating implants, for example ophthalmic implants for treatment of glaucoma.
BACKGROUND OF THE INVENTION
100021 U.S. Patent No. 5,868,697 discloses devices and methods for regulating fluid flow. The devices and methods are useful, for example, in the treatment of glaucoma, by providing for the flow of aqueous humor from the eye to reduce intraocular pressure (I0P).
[0003] As with the devices and methods disclosed in U.S. Patent No.
5,868,697, the devices and methods disclosed herein are also for regulating fluid flow.
The devices and methods disclosed herein are useful, for example, in the treatment of glaucoma, by providing for the flow of aqueous humor from the eye to reduce intraocular pressure (lOP).
SUMMARY OF THE INVENTION
[0004] In certain embodiments, the invention is directed to an improved flow regulating implant that has one or more grooves for allowing fluid flow.
[0005] In certain embodiments, one or more grooves may have a constant cross-section along its length.
[0006] In certain embodiments, one or more grooves may have a varying cross-section along its length. For example, one or more grooves may be tapered, as a funnel. The wider end may be at the inlet end or the outlet end.
[0007] In certain embodiments, one or more grooves may have in it biodegradable material, absorbable material, and/or threads or sutures.
[0008] In certain embodiments, a resilient band or coating may be placed around the implant or one or more grooves, to act as a pressure regulator.
[0009] In certain embodiments, in addition to one or more grooves, the implant may have a tube passage running through it. The tube passage may have in it biodegradable material, absorbable material, and/or threads or sutures.
[00010] In certain embodiments, the implant may have a side projection, such as a side pin, for engaging tissue. The side projection or pin may be useful for resisting rotation and/or firmly holding the implant within the tissue.
[00011] In certain embodiments, the implant may comprise two or more parts that BRIEF DESCRIPTION OF THE DRAWINGS
[00012] FIG. 1 is a perspective view of a first embodiment of a flow regulating implant;
[00014] FIG. 3 is an alternative perspective view of the flow regulating implant of FIG. 1;
[00015] FIG. 4 is a perspective view of the flow regulating implant of FIG. 1, [00016] FIG. 5 is a perspective view of the flow regulating implant of FIG. 1, with threads or sutures in the side grooves;
[00017] FIG. 6 is a perspective view of the flow regulating implant of FIG. 1, with a flow regulating band or coating around the implant;
[00021] FIG. 10 is a perspective view of an alternative embodiment of a flow regulating implant with side grooves, with a tube passage running through the 30 implant;
[00022] FIG. 11 is a perspective view of the flow regulating implant of FIG.
10, with a thread or suture in the tube passage;
HELD OF THE INVENTION
[0001] The invention relates generally to flow regulating implants, for example ophthalmic implants for treatment of glaucoma.
BACKGROUND OF THE INVENTION
100021 U.S. Patent No. 5,868,697 discloses devices and methods for regulating fluid flow. The devices and methods are useful, for example, in the treatment of glaucoma, by providing for the flow of aqueous humor from the eye to reduce intraocular pressure (I0P).
[0003] As with the devices and methods disclosed in U.S. Patent No.
5,868,697, the devices and methods disclosed herein are also for regulating fluid flow.
The devices and methods disclosed herein are useful, for example, in the treatment of glaucoma, by providing for the flow of aqueous humor from the eye to reduce intraocular pressure (lOP).
SUMMARY OF THE INVENTION
[0004] In certain embodiments, the invention is directed to an improved flow regulating implant that has one or more grooves for allowing fluid flow.
[0005] In certain embodiments, one or more grooves may have a constant cross-section along its length.
[0006] In certain embodiments, one or more grooves may have a varying cross-section along its length. For example, one or more grooves may be tapered, as a funnel. The wider end may be at the inlet end or the outlet end.
[0007] In certain embodiments, one or more grooves may have in it biodegradable material, absorbable material, and/or threads or sutures.
[0008] In certain embodiments, a resilient band or coating may be placed around the implant or one or more grooves, to act as a pressure regulator.
[0009] In certain embodiments, in addition to one or more grooves, the implant may have a tube passage running through it. The tube passage may have in it biodegradable material, absorbable material, and/or threads or sutures.
[00010] In certain embodiments, the implant may have a side projection, such as a side pin, for engaging tissue. The side projection or pin may be useful for resisting rotation and/or firmly holding the implant within the tissue.
[00011] In certain embodiments, the implant may comprise two or more parts that BRIEF DESCRIPTION OF THE DRAWINGS
[00012] FIG. 1 is a perspective view of a first embodiment of a flow regulating implant;
[00014] FIG. 3 is an alternative perspective view of the flow regulating implant of FIG. 1;
[00015] FIG. 4 is a perspective view of the flow regulating implant of FIG. 1, [00016] FIG. 5 is a perspective view of the flow regulating implant of FIG. 1, with threads or sutures in the side grooves;
[00017] FIG. 6 is a perspective view of the flow regulating implant of FIG. 1, with a flow regulating band or coating around the implant;
[00021] FIG. 10 is a perspective view of an alternative embodiment of a flow regulating implant with side grooves, with a tube passage running through the 30 implant;
[00022] FIG. 11 is a perspective view of the flow regulating implant of FIG.
10, with a thread or suture in the tube passage;
2 [00023] FIG. 12 is a perspective view of an alternative embodiment of a flow regulating implant, with a side pin;
[00024] FIG. 13 is a perspective view of an alternative embodiment of a flow regulating implant, comprising two parts that are held at a distance from each other to allow fluid flow between the parts;
[00025] FIG. 14 is a perspective view of an alternative embodiment of a flow regulating implant, comprising two parts that are held at a distance from each other to allow fluid flow between the parts, wherein the two parts may be pushed together or moved apart.
DETAILED DESCRIPTION
[00026] FIGS. 1 to 3 illustrate a first embodiment of a flow regulating implant.
The illustrated implant is in the form of an intraocular implant 10. The implant 10 comprises a shaft 11 and a flange (or plate or disk) 12. The cross-section of the shaft may take any suitable shape, for example square, rectangular, ellipsoidal, circular, or an irregular shape. In this illustrated embodiment, the plane of the flange 12 forms an angle with the shaft 11 that corresponds generally to the angle between the surface of the sclera of an eye and the intended axis of insertion of the implant 10. The flange 12 limits the depth of insertion and stabilizes the device. The angling of the flange 12 helps limit or prevent rotation of the device. In certain applications, it may be desired to remove the device, in which case the flange may be used for that purpose.
[00027] The implant 10 has an inlet end 13 and an outlet end 14. The flange 12 is connected to the shaft 11 at the outlet end 14 of the implant 10. The implant 10 may have one or more retention projections 15 for retaining the implant 10 after insertion. The retention projection(s) 15 may take any suitable form.
[00028] In the illustrated embodiment, the shaft 11 has a rounded tip at the inlet end 13 of the implant 10. It will be appreciated that the tip may take other suitable forms. For example, the tip may be a needle-like tip formed by a beveled surface, angled sharply for easy insertion into the eyeball.
[00029] The implant 10 has two side grooves 16A, 16B. In the illustrated embodiment, the side grooves 16A, 16B extend the full length of the implant 10,
[00024] FIG. 13 is a perspective view of an alternative embodiment of a flow regulating implant, comprising two parts that are held at a distance from each other to allow fluid flow between the parts;
[00025] FIG. 14 is a perspective view of an alternative embodiment of a flow regulating implant, comprising two parts that are held at a distance from each other to allow fluid flow between the parts, wherein the two parts may be pushed together or moved apart.
DETAILED DESCRIPTION
[00026] FIGS. 1 to 3 illustrate a first embodiment of a flow regulating implant.
The illustrated implant is in the form of an intraocular implant 10. The implant 10 comprises a shaft 11 and a flange (or plate or disk) 12. The cross-section of the shaft may take any suitable shape, for example square, rectangular, ellipsoidal, circular, or an irregular shape. In this illustrated embodiment, the plane of the flange 12 forms an angle with the shaft 11 that corresponds generally to the angle between the surface of the sclera of an eye and the intended axis of insertion of the implant 10. The flange 12 limits the depth of insertion and stabilizes the device. The angling of the flange 12 helps limit or prevent rotation of the device. In certain applications, it may be desired to remove the device, in which case the flange may be used for that purpose.
[00027] The implant 10 has an inlet end 13 and an outlet end 14. The flange 12 is connected to the shaft 11 at the outlet end 14 of the implant 10. The implant 10 may have one or more retention projections 15 for retaining the implant 10 after insertion. The retention projection(s) 15 may take any suitable form.
[00028] In the illustrated embodiment, the shaft 11 has a rounded tip at the inlet end 13 of the implant 10. It will be appreciated that the tip may take other suitable forms. For example, the tip may be a needle-like tip formed by a beveled surface, angled sharply for easy insertion into the eyeball.
[00029] The implant 10 has two side grooves 16A, 16B. In the illustrated embodiment, the side grooves 16A, 16B extend the full length of the implant 10,
3 from the inlet end 13 to the outlet end 14. The side grooves 16A, 16B are in the side of the shaft 11 and extend through the flange 12.
[00030] An implant in accordance with the invention may be inserted by methods disclosed in U.S. Patent No. 5,868,697. The insertion of the implant is not restricted to those methods. In certain instances, it may be desirable to implant the device such that the flange is located under scleral flap, i.e., a flap of tissue cut from the sclera. In such a method, a scleral flap is carefully cut from the sclera. The cut is preferably not made all the way through the sclera to the anterior chamber. Rather, the cut extends only part way through, to create the scleral flap that can be moved away to expose a place for insertion of the implant. With the scleral flap lifted, the implant is inserted in the intended implantation site, with the flange under the scleral flap. The implantation of the device under a scleral flap may assist in absorption of fluid. It also may assist in retention of the device.
[00031] With the device as illustrated in FIGS. 1 to 3, in operation, the grooves 16A, 16B form passageways for fluid to flow from the inlet end 13 toward the outlet end 14 of the implant 10. In the case of an intraocular implant, the aqueous humor in the eye can flow along the grooves from the inlet end 13 toward the outlet end 14.
[00032] The grooves 16A, 16B are directly adjacent the tissue into which the implant 10 is implanted. Thus, for example, the scleral tissue of the eye will surround the implant. In this manner, the sclera] tissue can function as a valve to control the flow of fluid out of the eye. When the pressure in the anterior chamber is low, the tissue is close around the implant and in the grooves to block or limit the flow of fluid along the grooves. When the pressure in the anterior chamber is elevated, the fluid exerts pressure on the tissue to clear the passageway along the grooves, and fluid will flow along the grooves between the implant device and the tissue.
[00033] With the grooves, the aqueous humor flowing out of the anterior chamber is allowed to directly contact the scleral tissue, which allows for direct absorption of the aqueous humor by the sclera. The fluid may be absorbed by the sclera or may flow out, for example underneath the conjunctiva.
[00034] The groove(s) may take any suitable form. For example, one or more grooves may be shaped as a funnel, tapering from one end to the other. The wider
[00030] An implant in accordance with the invention may be inserted by methods disclosed in U.S. Patent No. 5,868,697. The insertion of the implant is not restricted to those methods. In certain instances, it may be desirable to implant the device such that the flange is located under scleral flap, i.e., a flap of tissue cut from the sclera. In such a method, a scleral flap is carefully cut from the sclera. The cut is preferably not made all the way through the sclera to the anterior chamber. Rather, the cut extends only part way through, to create the scleral flap that can be moved away to expose a place for insertion of the implant. With the scleral flap lifted, the implant is inserted in the intended implantation site, with the flange under the scleral flap. The implantation of the device under a scleral flap may assist in absorption of fluid. It also may assist in retention of the device.
[00031] With the device as illustrated in FIGS. 1 to 3, in operation, the grooves 16A, 16B form passageways for fluid to flow from the inlet end 13 toward the outlet end 14 of the implant 10. In the case of an intraocular implant, the aqueous humor in the eye can flow along the grooves from the inlet end 13 toward the outlet end 14.
[00032] The grooves 16A, 16B are directly adjacent the tissue into which the implant 10 is implanted. Thus, for example, the scleral tissue of the eye will surround the implant. In this manner, the sclera] tissue can function as a valve to control the flow of fluid out of the eye. When the pressure in the anterior chamber is low, the tissue is close around the implant and in the grooves to block or limit the flow of fluid along the grooves. When the pressure in the anterior chamber is elevated, the fluid exerts pressure on the tissue to clear the passageway along the grooves, and fluid will flow along the grooves between the implant device and the tissue.
[00033] With the grooves, the aqueous humor flowing out of the anterior chamber is allowed to directly contact the scleral tissue, which allows for direct absorption of the aqueous humor by the sclera. The fluid may be absorbed by the sclera or may flow out, for example underneath the conjunctiva.
[00034] The groove(s) may take any suitable form. For example, one or more grooves may be shaped as a funnel, tapering from one end to the other. The wider
4 end may be at the outlet end or the inlet end, depending on the desired application.
Other modifications to the size, shape, and/or cross-sectional configuration of the groove(s) may be made.
[00035] It will be appreciated that in addition to the flow regulation characteristics, the grooves may serve the additional benefit of limiting or preventing rotation of the device. It will also be appreciated that non-circular cross-sections for the shaft will also help limit or prevent rotation of the device.
For example, a cross-section having comers, like a square, rectangular or other polygonal cross-section, will help limit or prevent rotation. In addition, a cross-section with different dimensions in different direction, like an elliptical or rectangular cross-section, will help limit or prevent rotation. The grooves may help to limit or prevent rotation even with an otherwise circular cross-section for the shaft. The tissue in the gutters may help hold the position of the device.
[000361 FIG. 4 illustrates the flow regulating implant of FIG. 1, with material 17
Other modifications to the size, shape, and/or cross-sectional configuration of the groove(s) may be made.
[00035] It will be appreciated that in addition to the flow regulation characteristics, the grooves may serve the additional benefit of limiting or preventing rotation of the device. It will also be appreciated that non-circular cross-sections for the shaft will also help limit or prevent rotation of the device.
For example, a cross-section having comers, like a square, rectangular or other polygonal cross-section, will help limit or prevent rotation. In addition, a cross-section with different dimensions in different direction, like an elliptical or rectangular cross-section, will help limit or prevent rotation. The grooves may help to limit or prevent rotation even with an otherwise circular cross-section for the shaft. The tissue in the gutters may help hold the position of the device.
[000361 FIG. 4 illustrates the flow regulating implant of FIG. 1, with material 17
5 in the side grooves. In this example, the material 17 may be a biodegradable material, an absorbable material, or a material that may be ablated with a laser.
Such materials may act to block or limit flow initially and to allow more flow over time. For example, a physician may ablate the laser-ablatable material at some period of time after implantation, or in increments over time. The biodegradable or absorbable material may act to block flow upon initial implantation and to erode or degrade over time to allow more flow. Further descriptions of the use of such materials in flow regulating implants are provided in U.S. Patent Nos.
Such materials may act to block or limit flow initially and to allow more flow over time. For example, a physician may ablate the laser-ablatable material at some period of time after implantation, or in increments over time. The biodegradable or absorbable material may act to block flow upon initial implantation and to erode or degrade over time to allow more flow. Further descriptions of the use of such materials in flow regulating implants are provided in U.S. Patent Nos.
6,203,513 and 6,558,342_ [000371 FIG. 5 illustrates the flow regulating implant of FIG. 1, with threads or sutures 18 in the side grooves. The threads or sutures 18 may act to block or limit flow initially and to allow more flow over time. For example, a physician may remove the threads or sutures 18 at some period of time after implantation, or may remove one at a time in increments over time. It will be appreciated that more than one thread or suture 18 may be placed in each groove. Further descriptions of the use of threads or sutures in flow regulating implants are provided in U.S.
Patent No.
6,558,342.
[00038] FIG. 6 illustrates the flow regulating implant of FIG. 1, with a flow regulating band or coating 19 around the implant. The band or coating 19 may extend over only part of the length of the implant, as illustrated, or, alternatively, it may extend over the full length of the implant. The band or coating 19 may be shaped to extend into the grooves. The band or coating 19 is resilient and acts as valve to control the flow of fluid out of the eye. When the pressure in the anterior chamber is low, the band or coating 19 is close around the implant and in the grooves to block or limit the flow of fluid along the grooves. When the pressure in the anterior chamber is elevated, the fluid exerts pressure on the band or coating 19 to clear the passageway along the grooves, and fluid will flow along the grooves between the implant shaft and the band or coating 19.
[00039] FIG. 7 illustrates another embodiment of a flow regulating implant.
This flow regulating implant 20 is similar to the flow regulating implant 10. The flow regulating implant 20 has a shaft 21, a flange 22, and grooves 26A, 26B
(groove 26B not shown). In this embodiment, the flange has holes 27A, 27B in it at the outlet ends of the grooves 26A, 26B, respectively. These holes allow the flow of fluid away from the implant.
[00040] FIG. 8 illustrates another embodiment of a flow regulating implant.
This flow regulating implant 30 is similar to the flow regulating implants described above. The flow regulating implant 30 has a shaft 31, a flange 32, and grooves 36A, 36B. In this embodiment, the flange has a hole 38 in it. With this hole, a suture may be used to attach the implant to tissue to fix it in place.
[00041] FIG. 9 illustrates a flow regulating implant 40. This flow regulating implant 40 is similar to the flow regulating implants described above. The flow regulating implant 40 has a shaft 41, a flange 42, and grooves 46A, 46B. In this embodiment, the flange 42 has a different shape, which may be useful in certain applications.
[00042] FIG. 10 is a perspective view of an alternative embodiment of a flow regulating implant with side grooves. The implant 50 has tube passage 51 running through the implant. This tube passage 51 provides an additional passageway for fluid flow. The tube passage may have in it absorbable, biodegradable, laser-ablatable and/or removable material for blocking or partially obstructing fluid flow, and for allowing further flow over time. FIG. 11 illustrates the flow regulating implant of FIG. 10, with a thread or suture 58 in the tube passage 51.
[00043] FIG. 12 is a perspective view of an alternative embodiment of a flow regulating implant 60, with a side projection in the form of a side pin 68.
Upon implantation, the pin 68 is fixed in the scleral tissue and serves to resist rotation of the device. The pin 68 may also assist in holding the device in the sclera, providing a sealing of the sclera around the shaft of the implant to prevent undesired leakage.
The pin also fixes the device to prevent the possibility of the device pressing on and eroding the conjunctiva.
[00044] The projection or pin could be may of any suitable material, and it could be removable or changeable. For example, the projection or pin could be made of absorbable, biodegradable, laser-ablatable and/or removable material. The projection or pin 68 could be movable with a hole in the shaft 61, so that its length of projection from the shaft 61 could be adjustable. Also, a slot or other holes could be provided to allow adjustment of the positioning of the projection or pin.
[00045] FIG. 13 is a perspective view of an alternative embodiment of a flow regulating implant. The implant 70 comprises two parts 71, 72 that are held at a distance from each other to allow fluid flow between the parts. In implant 70, the two parts 71, 72 are joined to each other by two cylinders 73A, 73B. The implant may be formed as one piece, or the parts may be joined by any suitable means, for example welding. The two parts 71, 72 may be joined by just one cylinder or by parts of other shapes, for example, one or more spheres. Alternatively, the two parts may be shaped to be joined directly together with a space between them. It will be appreciated that the space 74 between the parts 71, 72 provides a space for the flow of fluid and allows further fluid contact with the sclera.
[00046] FIG. 14 illustrates a flow regulating implant 80 comprising two parts 81, 82 that are formed together as parts of a single, one-piece device. It will be appreciated that the space 84 between the parts 81, 82 provides a space for the flow of fluid and allows further fluid contact with the sclera, similar to the implant 70.
The two parts 81, 82 may be pushed together or moved apart, which can control the spacing and thus the fluid flow.
[00047] An implant constructed in accordance with the invention may be manufactured entirely from or covered with any suitable material, such as stainless steel, silicon, gold, nitinol, Teflon, tantalum, PMMA, or any other suitable metallic or polymeric or other material. The entire device may be made from a degradable
Patent No.
6,558,342.
[00038] FIG. 6 illustrates the flow regulating implant of FIG. 1, with a flow regulating band or coating 19 around the implant. The band or coating 19 may extend over only part of the length of the implant, as illustrated, or, alternatively, it may extend over the full length of the implant. The band or coating 19 may be shaped to extend into the grooves. The band or coating 19 is resilient and acts as valve to control the flow of fluid out of the eye. When the pressure in the anterior chamber is low, the band or coating 19 is close around the implant and in the grooves to block or limit the flow of fluid along the grooves. When the pressure in the anterior chamber is elevated, the fluid exerts pressure on the band or coating 19 to clear the passageway along the grooves, and fluid will flow along the grooves between the implant shaft and the band or coating 19.
[00039] FIG. 7 illustrates another embodiment of a flow regulating implant.
This flow regulating implant 20 is similar to the flow regulating implant 10. The flow regulating implant 20 has a shaft 21, a flange 22, and grooves 26A, 26B
(groove 26B not shown). In this embodiment, the flange has holes 27A, 27B in it at the outlet ends of the grooves 26A, 26B, respectively. These holes allow the flow of fluid away from the implant.
[00040] FIG. 8 illustrates another embodiment of a flow regulating implant.
This flow regulating implant 30 is similar to the flow regulating implants described above. The flow regulating implant 30 has a shaft 31, a flange 32, and grooves 36A, 36B. In this embodiment, the flange has a hole 38 in it. With this hole, a suture may be used to attach the implant to tissue to fix it in place.
[00041] FIG. 9 illustrates a flow regulating implant 40. This flow regulating implant 40 is similar to the flow regulating implants described above. The flow regulating implant 40 has a shaft 41, a flange 42, and grooves 46A, 46B. In this embodiment, the flange 42 has a different shape, which may be useful in certain applications.
[00042] FIG. 10 is a perspective view of an alternative embodiment of a flow regulating implant with side grooves. The implant 50 has tube passage 51 running through the implant. This tube passage 51 provides an additional passageway for fluid flow. The tube passage may have in it absorbable, biodegradable, laser-ablatable and/or removable material for blocking or partially obstructing fluid flow, and for allowing further flow over time. FIG. 11 illustrates the flow regulating implant of FIG. 10, with a thread or suture 58 in the tube passage 51.
[00043] FIG. 12 is a perspective view of an alternative embodiment of a flow regulating implant 60, with a side projection in the form of a side pin 68.
Upon implantation, the pin 68 is fixed in the scleral tissue and serves to resist rotation of the device. The pin 68 may also assist in holding the device in the sclera, providing a sealing of the sclera around the shaft of the implant to prevent undesired leakage.
The pin also fixes the device to prevent the possibility of the device pressing on and eroding the conjunctiva.
[00044] The projection or pin could be may of any suitable material, and it could be removable or changeable. For example, the projection or pin could be made of absorbable, biodegradable, laser-ablatable and/or removable material. The projection or pin 68 could be movable with a hole in the shaft 61, so that its length of projection from the shaft 61 could be adjustable. Also, a slot or other holes could be provided to allow adjustment of the positioning of the projection or pin.
[00045] FIG. 13 is a perspective view of an alternative embodiment of a flow regulating implant. The implant 70 comprises two parts 71, 72 that are held at a distance from each other to allow fluid flow between the parts. In implant 70, the two parts 71, 72 are joined to each other by two cylinders 73A, 73B. The implant may be formed as one piece, or the parts may be joined by any suitable means, for example welding. The two parts 71, 72 may be joined by just one cylinder or by parts of other shapes, for example, one or more spheres. Alternatively, the two parts may be shaped to be joined directly together with a space between them. It will be appreciated that the space 74 between the parts 71, 72 provides a space for the flow of fluid and allows further fluid contact with the sclera.
[00046] FIG. 14 illustrates a flow regulating implant 80 comprising two parts 81, 82 that are formed together as parts of a single, one-piece device. It will be appreciated that the space 84 between the parts 81, 82 provides a space for the flow of fluid and allows further fluid contact with the sclera, similar to the implant 70.
The two parts 81, 82 may be pushed together or moved apart, which can control the spacing and thus the fluid flow.
[00047] An implant constructed in accordance with the invention may be manufactured entirely from or covered with any suitable material, such as stainless steel, silicon, gold, nitinol, Teflon, tantalum, PMMA, or any other suitable metallic or polymeric or other material. The entire device may be made from a degradable
7 material. The device may be made by molding or any other suitable method of manufacture. The device may be manufactured as one piece or as separate pieces that are joined together. The implant may be coated with heparin or any other suitable coating.
[00048] Implants in accordance with the invention may be provided with other features and/or implanted with delivery devices and/or by other methods, for example those disclosed in U.S. Patent Nos. 5,868,697; 6,203,513 and 6,558,342, discussed above.
[00049] As will be appreciated by persons having ordinary skill in the art, the various embodiments of implants described hereinabove are given by way of example only. Various changes, modifications and variations may be applied to the described embodiments without departing from the scope of the invention, defined by the appended claims.
[00048] Implants in accordance with the invention may be provided with other features and/or implanted with delivery devices and/or by other methods, for example those disclosed in U.S. Patent Nos. 5,868,697; 6,203,513 and 6,558,342, discussed above.
[00049] As will be appreciated by persons having ordinary skill in the art, the various embodiments of implants described hereinabove are given by way of example only. Various changes, modifications and variations may be applied to the described embodiments without departing from the scope of the invention, defined by the appended claims.
8
Claims (7)
1. An implant for regulating fluid flow, the implant comprising:
(a) an elongated portion comprising an insertion tip, an inlet and an outlet, a first elongated part and a second elongated part; wherein said insertion tip has a proximal end and a distal end, said proximal end of said insertion tip joining said first and second elongated parts, said first and second elongated parts disposed such that a greatest dimension thereof is a length thereof measured along an axial direction. and wherein a space extends along said elongated portion substantially in said axial direction between said first and second elongated parts, said space comprising said inlet disposed at said proximal end of said insertion tip and extending along said elongated portion substantially in said axial direction such that said space forms a flowpath from said inlet to said outlet;
wherein said elongated portion further comprises a first lateral side and a second lateral side, such that said space forms a channel from said first lateral side of said elongated portion to said second lateral side of said elongated portion; and (b) a flange attached to at least the first elongated part, the flange being located at the outlet of the elongated portion.
(a) an elongated portion comprising an insertion tip, an inlet and an outlet, a first elongated part and a second elongated part; wherein said insertion tip has a proximal end and a distal end, said proximal end of said insertion tip joining said first and second elongated parts, said first and second elongated parts disposed such that a greatest dimension thereof is a length thereof measured along an axial direction. and wherein a space extends along said elongated portion substantially in said axial direction between said first and second elongated parts, said space comprising said inlet disposed at said proximal end of said insertion tip and extending along said elongated portion substantially in said axial direction such that said space forms a flowpath from said inlet to said outlet;
wherein said elongated portion further comprises a first lateral side and a second lateral side, such that said space forms a channel from said first lateral side of said elongated portion to said second lateral side of said elongated portion; and (b) a flange attached to at least the first elongated part, the flange being located at the outlet of the elongated portion.
2. The implant of claim 1, wherein the flange projects from the first elongated part at an angle with respect to the first elongated part.
3. The implant of claim 1 or 2, wherein the first elongated part and the second elongated part are formed together as parts of a single, one-piece implant.
4, The implant of claim 1, wherein a distance between the first elongated part and the second elongated part is adjustable such that the first elongated part and second elongated part may be pushed together to a first position in which they are separated by a first distance and moved apart to a second position in which they are separated by a second distance greater than the first distance.
5. The implant of claim 4, wherein the flange projects from the first elongated part at an angle with respect to the first elongated part.
6. The implant of claim 4, wherein the first elongated part and the second elongated part are formed together as parts of a single, one-piece implant.
7. The implant of claim 1, wherein the first part and second part are joined to each other by an additional piece.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/875,571 | 2004-06-25 | ||
US10/875,571 US7862531B2 (en) | 2004-06-25 | 2004-06-25 | Flow regulating implants |
PCT/US2005/021123 WO2006012009A2 (en) | 2004-06-25 | 2005-06-16 | Flow regulating implants |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2571871A1 CA2571871A1 (en) | 2006-02-02 |
CA2571871C true CA2571871C (en) | 2014-02-04 |
Family
ID=35116140
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2571871A Expired - Fee Related CA2571871C (en) | 2004-06-25 | 2005-06-16 | Flow regulating implants |
Country Status (11)
Country | Link |
---|---|
US (2) | US7862531B2 (en) |
EP (1) | EP1765234B1 (en) |
JP (1) | JP4723577B2 (en) |
KR (1) | KR101280961B1 (en) |
CN (2) | CN100577127C (en) |
AU (1) | AU2005267539B2 (en) |
CA (1) | CA2571871C (en) |
ES (1) | ES2753384T3 (en) |
IL (1) | IL180170A0 (en) |
SG (1) | SG153828A1 (en) |
WO (1) | WO2006012009A2 (en) |
Families Citing this family (65)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8313454B2 (en) * | 1997-11-20 | 2012-11-20 | Optonol Ltd. | Fluid drainage device, delivery device, and associated methods of use and manufacture |
BR0010055A (en) | 1999-04-26 | 2002-04-09 | Gmp Vision Solutions Inc | Bypass device and use thereof |
US6554119B2 (en) * | 2000-02-07 | 2003-04-29 | Progressive Tool & Industries Co. | Flexible automotive assembly line and method |
US7867186B2 (en) | 2002-04-08 | 2011-01-11 | Glaukos Corporation | Devices and methods for treatment of ocular disorders |
US7135009B2 (en) | 2001-04-07 | 2006-11-14 | Glaukos Corporation | Glaucoma stent and methods thereof for glaucoma treatment |
US6638239B1 (en) | 2000-04-14 | 2003-10-28 | Glaukos Corporation | Apparatus and method for treating glaucoma |
US7431710B2 (en) | 2002-04-08 | 2008-10-07 | Glaukos Corporation | Ocular implants with anchors and methods thereof |
US7331984B2 (en) | 2001-08-28 | 2008-02-19 | Glaukos Corporation | Glaucoma stent for treating glaucoma and methods of use |
US20040225250A1 (en) | 2003-05-05 | 2004-11-11 | Michael Yablonski | Internal shunt and method for treating glaucoma |
US7291125B2 (en) | 2003-11-14 | 2007-11-06 | Transcend Medical, Inc. | Ocular pressure regulation |
US20050194303A1 (en) * | 2004-03-02 | 2005-09-08 | Sniegowski Jeffry J. | MEMS flow module with filtration and pressure regulation capabilities |
US7544176B2 (en) * | 2005-06-21 | 2009-06-09 | Becton, Dickinson And Company | Glaucoma implant having MEMS flow module with flexing diaphragm for pressure regulation |
US7226540B2 (en) * | 2004-02-24 | 2007-06-05 | Becton, Dickinson And Company | MEMS filter module |
US7862531B2 (en) * | 2004-06-25 | 2011-01-04 | Optonol Ltd. | Flow regulating implants |
US20080108932A1 (en) * | 2005-08-24 | 2008-05-08 | Rodgers M Steven | MEMS filter module with multi-level filter traps |
US9084662B2 (en) | 2006-01-17 | 2015-07-21 | Transcend Medical, Inc. | Drug delivery treatment device |
ES2762239T3 (en) | 2006-01-17 | 2020-05-22 | Alcon Inc | Glaucoma treatment device |
EP3351211B1 (en) * | 2006-07-11 | 2023-09-06 | Refocus Group, Inc. | Scleral prosthesis for treating presbyopia and other eye disorders |
US8911496B2 (en) * | 2006-07-11 | 2014-12-16 | Refocus Group, Inc. | Scleral prosthesis for treating presbyopia and other eye disorders and related devices and methods |
WO2008154502A1 (en) * | 2007-06-07 | 2008-12-18 | Yale University | Uveoscleral drainage device |
EP2173289A4 (en) | 2007-07-17 | 2010-11-24 | Transcend Medical Inc | Ocular implant with hydrogel expansion capabilities |
ES2640867T3 (en) | 2008-06-25 | 2017-11-07 | Novartis Ag | Eye implant with ability to change shape |
US8353856B2 (en) | 2008-11-05 | 2013-01-15 | Abbott Medical Optics Inc. | Glaucoma drainage shunts and methods of use |
EP2548538B1 (en) | 2009-01-28 | 2020-04-01 | Alcon Inc. | Implantation systems for ocular implants with stiffness qualities |
AU2010229789B2 (en) | 2009-03-26 | 2014-11-13 | Johnson & Johnson Surgical Vision, Inc. | Glaucoma shunts with flow management and improved surgical performance |
WO2011008981A1 (en) * | 2009-07-15 | 2011-01-20 | Regents Of The University Of Minnesota | Implantable devices for treatment of sinusitis |
US8529492B2 (en) | 2009-12-23 | 2013-09-10 | Trascend Medical, Inc. | Drug delivery devices and methods |
WO2011089605A2 (en) * | 2010-01-22 | 2011-07-28 | The Medical Research, Infrastructure, And Health Services Fund Of The Tel Aviv Medical Center | Ocular shunt |
CN103179927B (en) | 2010-08-12 | 2016-09-07 | 南洋理工大学 | Glaucoma Valve, for accommodating glaucoma valve housing and comprise the glaucoma drainage device of this valve and/or this housing |
US8771220B2 (en) * | 2011-12-07 | 2014-07-08 | Alcon Research, Ltd. | Glaucoma active pressure regulation shunt |
US8765210B2 (en) | 2011-12-08 | 2014-07-01 | Aquesys, Inc. | Systems and methods for making gelatin shunts |
CA2868341C (en) | 2012-03-26 | 2021-01-12 | Glaukos Corporation | System and method for delivering multiple ocular implants |
WO2013155252A1 (en) * | 2012-04-11 | 2013-10-17 | Baylor College Of Medicine | Ophthalmic implant |
US10085633B2 (en) | 2012-04-19 | 2018-10-02 | Novartis Ag | Direct visualization system for glaucoma treatment |
US9241832B2 (en) | 2012-04-24 | 2016-01-26 | Transcend Medical, Inc. | Delivery system for ocular implant |
US8858491B2 (en) * | 2012-05-23 | 2014-10-14 | Alcon Research, Ltd. | Pre-biased membrane valve |
EP3228286A1 (en) | 2012-09-17 | 2017-10-11 | Novartis AG | Expanding ocular impant devices |
WO2014078288A1 (en) | 2012-11-14 | 2014-05-22 | Transcend Medical, Inc. | Flow promoting ocular implant |
US10159600B2 (en) | 2013-02-19 | 2018-12-25 | Aquesys, Inc. | Adjustable intraocular flow regulation |
US9125723B2 (en) | 2013-02-19 | 2015-09-08 | Aquesys, Inc. | Adjustable glaucoma implant |
CN105358105A (en) * | 2013-03-14 | 2016-02-24 | 以色列哈尼塔镜片有限公司 | Miniature glaucoma shunt |
US10517759B2 (en) | 2013-03-15 | 2019-12-31 | Glaukos Corporation | Glaucoma stent and methods thereof for glaucoma treatment |
US9987163B2 (en) | 2013-04-16 | 2018-06-05 | Novartis Ag | Device for dispensing intraocular substances |
US9226851B2 (en) | 2013-08-24 | 2016-01-05 | Novartis Ag | MEMS check valve chip and methods |
KR20150034010A (en) * | 2013-09-25 | 2015-04-02 | 사회복지법인 삼성생명공익재단 | An Apparatus for Treating Ocular Diseases Induced by Increased Intraocular Pressure |
JP6393471B2 (en) * | 2013-11-07 | 2018-09-19 | テルモ株式会社 | Medical treatment tool |
US20150342875A1 (en) | 2014-05-29 | 2015-12-03 | Dose Medical Corporation | Implants with controlled drug delivery features and methods of using same |
EP3240510A4 (en) | 2014-12-31 | 2018-09-19 | Microoptx Inc. | Glaucoma treatment devices and methods |
WO2017040853A1 (en) | 2015-09-02 | 2017-03-09 | Glaukos Corporation | Drug delivery implants with bi-directional delivery capacity |
WO2017059272A1 (en) | 2015-09-30 | 2017-04-06 | Microoptx Inc. | Dry eye treatment devices and methods |
KR102573821B1 (en) * | 2017-02-16 | 2023-08-31 | 마이크로서지컬 테크놀로지, 인코퍼레이티드 | Apparatus, system and method for minimally invasive glaucoma surgery |
CA3062857A1 (en) * | 2017-05-14 | 2018-11-22 | Navigate Cardiac Structures, Inc. | Valved stent for orthotopic replacement of dysfunctional cardiac valve and delivery system |
EP3638164B1 (en) * | 2017-06-13 | 2023-05-10 | Innfocus, Inc. | Systems and apparatus for treatment of glaucoma |
US11166849B2 (en) | 2017-07-20 | 2021-11-09 | Shifamed Holdings, Llc | Adjustable flow glaucoma shunts and methods for making and using same |
CA3070108A1 (en) | 2017-07-20 | 2019-01-24 | Shifamed Holdings, Llc | Adjustable flow glaucoma shunts and methods for making and using same |
US11116625B2 (en) | 2017-09-28 | 2021-09-14 | Glaukos Corporation | Apparatus and method for controlling placement of intraocular implants |
CN108542718B (en) * | 2018-04-25 | 2019-07-26 | 张连存 | A kind of wearable flexible lower limb exoskeleton based on negative pressure rotary pneumatic artificial-muscle |
US11672701B2 (en) | 2018-10-25 | 2023-06-13 | Amo Groningen B.V. | Bleb control glaucoma shunts |
JP2022552284A (en) | 2019-10-10 | 2022-12-15 | シファメド・ホールディングス・エルエルシー | Adjustable flow glaucoma shunt and related systems and methods |
WO2021151007A1 (en) | 2020-01-23 | 2021-07-29 | Shifamed Holdings, Llc | Adjustable flow glaucoma shunts and associated systems and methods |
CA3167488A1 (en) | 2020-02-14 | 2021-08-19 | Eric Schultz | Shunting systems with rotation-based flow control assemblies, and associated systems and methods |
US11737920B2 (en) | 2020-02-18 | 2023-08-29 | Shifamed Holdings, Llc | Adjustable flow glaucoma shunts having non-linearly arranged flow control elements, and associated systems and methods |
US11766355B2 (en) | 2020-03-19 | 2023-09-26 | Shifamed Holdings, Llc | Intraocular shunts with low-profile actuation elements and associated systems and methods |
JP2023522332A (en) | 2020-04-16 | 2023-05-30 | シファメド・ホールディングス・エルエルシー | ADJUSTABLE GLAUCOMA TREATMENT DEVICES AND RELATED SYSTEMS AND METHODS |
WO2022159723A1 (en) | 2021-01-22 | 2022-07-28 | Shifamed Holdings, Llc | Adjustable shunting systems with plate assemblies, and associated systems and methods |
Family Cites Families (166)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US15192A (en) * | 1856-06-24 | Tubular | ||
US274447A (en) * | 1883-03-20 | William-kentish | ||
US733152A (en) * | 1902-08-30 | 1903-07-07 | Murdoch Chisholm | Empyema drainage device. |
US1388172A (en) * | 1920-03-18 | 1921-08-23 | Simon M Craddock | Veterinary surgical appliance |
US2431587A (en) | 1945-02-19 | 1947-11-25 | Charles F Schnee | Cannula button for surgical operations and method of use |
US2555076A (en) * | 1947-11-17 | 1951-05-29 | Elijah R Crossley | Instrument for use in performing surgical eye operations |
US2867213A (en) * | 1957-06-12 | 1959-01-06 | Jr Paul A Thomas | Flutter valve for drainage of the pleural cavity |
US3159161A (en) | 1962-11-14 | 1964-12-01 | Ness Richard Alton | Fistulizing canaliculus |
US3310051A (en) * | 1963-12-10 | 1967-03-21 | Rudolf R Schulte | Surgical reservoir for implantation beneath the skin |
US3333588A (en) * | 1964-07-06 | 1967-08-01 | Rudolf R Schulte | Brain ventricle cannula |
US3272204A (en) | 1965-09-22 | 1966-09-13 | Ethicon Inc | Absorbable collagen prosthetic implant with non-absorbable reinforcing strands |
US3421509A (en) * | 1965-12-17 | 1969-01-14 | John M Fiore | Urethral catheter |
US3530860A (en) | 1967-01-09 | 1970-09-29 | Ponce De Leon Ear | Method and apparatus for inserting a tube through the ear drum |
US3589401A (en) * | 1969-07-18 | 1971-06-29 | Case Co J I | Pressure modulating valve |
US3915172A (en) | 1970-05-27 | 1975-10-28 | Ceskoslovenska Akademie Ved | Capillary drain for glaucoma |
US3788327A (en) * | 1971-03-30 | 1974-01-29 | H Donowitz | Surgical implant device |
US3884238A (en) * | 1972-06-19 | 1975-05-20 | Malley Conor C O | Apparatus for intraocular surgery |
US3957035A (en) * | 1972-09-08 | 1976-05-18 | Jean Chassaing | Ophthalmological device useful for eye surgery |
US3890976A (en) * | 1972-10-26 | 1975-06-24 | Medical Products Corp | Catheter tip assembly |
US3913584A (en) | 1974-06-28 | 1975-10-21 | Xomox Corp | Combination myringotomy scalpel, aspirator and otological vent tube inserter |
US3938529A (en) * | 1974-07-22 | 1976-02-17 | Gibbons Robert P | Indwelling ureteral catheter |
US4093708A (en) * | 1974-12-23 | 1978-06-06 | Alza Corporation | Osmotic releasing device having a plurality of release rate patterns |
US3976077A (en) * | 1975-02-03 | 1976-08-24 | Kerfoot Jr Franklin W | Eye surgery device |
US4037604A (en) * | 1976-01-05 | 1977-07-26 | Newkirk John B | Artifical biological drainage device |
US4153058A (en) * | 1977-07-05 | 1979-05-08 | Nehme Alexander E | Pleural decompression catheter |
US4175563A (en) | 1977-10-05 | 1979-11-27 | Arenberg Irving K | Biological drainage shunt |
US4290426A (en) | 1978-05-04 | 1981-09-22 | Alza Corporation | Dispenser for dispensing beneficial agent |
US4299227A (en) | 1979-10-19 | 1981-11-10 | Lincoff Harvey A | Ophthalmological appliance |
US4303063A (en) | 1980-03-06 | 1981-12-01 | Stahl Norman O | Ocular massage device |
US4808183A (en) * | 1980-06-03 | 1989-02-28 | University Of Iowa Research Foundation | Voice button prosthesis and method for installing same |
US4402681A (en) | 1980-08-23 | 1983-09-06 | Haas Joseph S | Artificial implant valve for the regulation of intraocular pressure |
US4457757A (en) * | 1981-07-20 | 1984-07-03 | Molteno Anthony C B | Device for draining aqueous humour |
FR2514852B1 (en) * | 1981-10-19 | 1985-09-27 | Snecma | FLUID DISPENSING MEMBER AND METHOD FOR PRODUCING THE BODY OF THIS MEMBER |
US4474569A (en) | 1982-06-28 | 1984-10-02 | Denver Surgical Developments, Inc. | Antenatal shunt |
US4554918A (en) | 1982-07-28 | 1985-11-26 | White Thomas C | Ocular pressure relief device |
US4521210A (en) * | 1982-12-27 | 1985-06-04 | Wong Vernon G | Eye implant for relieving glaucoma, and device and method for use therewith |
IT8352816V0 (en) * | 1983-01-07 | 1983-01-07 | Ferrando Ugo Gardi Giovanni E | SURGICAL MEDICAL APPLICATION CATHETER |
HU187011B (en) * | 1983-01-14 | 1985-10-28 | Orvosi Mueszer Sz | Trachea canula |
SU1191227A1 (en) | 1983-04-28 | 1985-11-15 | Всесоюзный Научно-Исследовательский И Проектный Институт Технологии Химического И Нефтяного Аппаратостроения | Line for manufacturing ribbed bimetallic pipes |
US4538611A (en) | 1983-06-13 | 1985-09-03 | Kelman Charles D | Surgical instrument and method of cutting a lens of an eye |
NL8302541A (en) * | 1983-07-15 | 1985-02-01 | Philips Nv | METHOD FOR MANUFACTURING A SEMICONDUCTOR DEVICE, AND SEMICONDUCTOR DEVICE MADE ACCORDING TO THE METHOD |
US4587954A (en) * | 1983-12-29 | 1986-05-13 | Habley Medical Technology Corporation | Elastomeric prosthetic sphincter |
US4563779A (en) * | 1984-01-27 | 1986-01-14 | Kelman Charles D | Corneal implant and method of making the same |
US4578058A (en) * | 1984-04-02 | 1986-03-25 | Grandon Stanley C | Intraocular catheter apparatus and method of use |
US4787885A (en) | 1984-04-06 | 1988-11-29 | Binder Perry S | Hydrogel seton |
US4634418A (en) * | 1984-04-06 | 1987-01-06 | Binder Perry S | Hydrogel seton |
US4660546A (en) * | 1984-11-07 | 1987-04-28 | Robert S. Herrick | Method for treating for deficiency of tears |
US4604087A (en) * | 1985-02-26 | 1986-08-05 | Joseph Neil H | Aqueous humor drainage device |
US4781675A (en) | 1985-11-27 | 1988-11-01 | White Thomas C | Infusion cannula |
US4692142A (en) | 1986-02-24 | 1987-09-08 | Dignam Bernard J | Sutureless infusion cannula for ophthalmic surgery |
US4792336A (en) * | 1986-03-03 | 1988-12-20 | American Cyanamid Company | Flat braided ligament or tendon implant device having texturized yarns |
NZ215409A (en) * | 1986-03-07 | 1989-02-24 | Anthony Christopher Be Molteno | Implant for drainage of aqueous humour in glaucoma |
US4964850A (en) | 1986-05-07 | 1990-10-23 | Vincent Bouton | Method for treating trans-nasal sinus afflictions using a double t-shaped trans-nasal aerator |
US4826478A (en) * | 1986-06-23 | 1989-05-02 | Stanley Schocket | Anterior chamber tube shunt to an encircling band, and related surgical procedure |
US4722724A (en) * | 1986-06-23 | 1988-02-02 | Stanley Schocket | Anterior chamber tube shunt to an encircling band, and related surgical procedure |
US4909783A (en) * | 1986-07-16 | 1990-03-20 | Morrison David P | Intra-ocular pressure apparatus |
US4751926A (en) * | 1986-09-12 | 1988-06-21 | Dow Corning Wright Corporation | Instrument for subcutaneous insertion of an injection reservoir |
US4863457A (en) | 1986-11-24 | 1989-09-05 | Lee David A | Drug delivery device |
US4886488A (en) | 1987-08-06 | 1989-12-12 | White Thomas C | Glaucoma drainage the lacrimal system and method |
EP0375676A1 (en) * | 1987-08-19 | 1990-07-04 | BERG, Olle | A drainage tube for sinus maxillaris, a means for its insertion and a means for making a hole for its positioning |
US4813941A (en) * | 1987-09-03 | 1989-03-21 | Leslie Shea | Pneumothorax treatment device |
US4934363A (en) * | 1987-12-15 | 1990-06-19 | Iolab Corporation | Lens insertion instrument |
US4888016A (en) * | 1988-02-10 | 1989-12-19 | Langerman David W | "Spare parts" for use in ophthalmic surgical procedures |
US4936825A (en) | 1988-04-11 | 1990-06-26 | Ungerleider Bruce A | Method for reducing intraocular pressure caused by glaucoma |
US5098393A (en) * | 1988-05-31 | 1992-03-24 | Kurt Amplatz | Medical introducer and valve assembly |
US4915684A (en) * | 1988-06-21 | 1990-04-10 | Mackeen Donald L | Method and apparatus for modulating the flow of lacrimal fluid through a punctum and associated canaliculus |
US5616118A (en) * | 1988-10-07 | 1997-04-01 | Ahmed; Abdul M. | Uniquely shaped ophthalmological device |
US5071408A (en) | 1988-10-07 | 1991-12-10 | Ahmed Abdul Mateen | Medical valve |
IT1227176B (en) | 1988-10-11 | 1991-03-20 | Co Pharma Corp Srl | DEVICE FOR FIXING A CATHETER TO THE CRANIAL TECA FOR EXTERNAL LIQUOR DERIVATION |
US4959048A (en) | 1989-01-17 | 1990-09-25 | Helix Medical, Inc. | Lacrimal duct occluder |
US5000731A (en) * | 1989-03-30 | 1991-03-19 | Tai-Ting Wong | Shunting device adopted in the intracranial shunting surgical operation for the treatment of hydrocephalus |
US5053040A (en) | 1989-11-09 | 1991-10-01 | Goldsmith Iii Manning M | Method of performing a myringotomy |
US4946436A (en) * | 1989-11-17 | 1990-08-07 | Smith Stewart G | Pressure-relieving device and process for implanting |
US5167620A (en) | 1989-11-28 | 1992-12-01 | Alexandar Ureche | Eye surgery methods |
US5106367A (en) * | 1989-11-28 | 1992-04-21 | Alexander Ureche | Eye surgery apparatus with vacuum surge suppressor |
US5092837A (en) * | 1989-12-20 | 1992-03-03 | Robert Ritch | Method for the treatment of glaucoma |
US4968296A (en) | 1989-12-20 | 1990-11-06 | Robert Ritch | Transscleral drainage implant device for the treatment of glaucoma |
US5073163A (en) | 1990-01-29 | 1991-12-17 | Lippman Myron E | Apparatus for treating glaucoma |
US5171270A (en) | 1990-03-29 | 1992-12-15 | Herrick Robert S | Canalicular implant having a collapsible flared section and method |
US5041081A (en) * | 1990-05-18 | 1991-08-20 | Odrich Ronald B | Ocular implant for controlling glaucoma |
US5127901A (en) * | 1990-05-18 | 1992-07-07 | Odrich Ronald B | Implant with subconjunctival arch |
US5476445A (en) | 1990-05-31 | 1995-12-19 | Iovision, Inc. | Glaucoma implant with a temporary flow restricting seal |
US5178604A (en) * | 1990-05-31 | 1993-01-12 | Iovision, Inc. | Glaucoma implant |
US5397300A (en) * | 1990-05-31 | 1995-03-14 | Iovision, Inc. | Glaucoma implant |
US5098438A (en) * | 1990-08-23 | 1992-03-24 | Siepser Steven B | Procedures for intraocular surgery |
CA2060635A1 (en) | 1991-02-12 | 1992-08-13 | Keith D'alessio | Bioabsorbable medical implants |
US5454796A (en) | 1991-04-09 | 1995-10-03 | Hood Laboratories | Device and method for controlling intraocular fluid pressure |
US5242449A (en) | 1991-04-23 | 1993-09-07 | Allergan, Inc. | Ophthalmic instrument |
US5207660A (en) * | 1991-04-26 | 1993-05-04 | Cornell Research Foundation, Inc. | Method for the delivery of compositions to the ocular tissues |
US5358492A (en) | 1991-05-02 | 1994-10-25 | Feibus Miriam H | Woven surgical drain and method of making |
US6007511A (en) | 1991-05-08 | 1999-12-28 | Prywes; Arnold S. | Shunt valve and therapeutic delivery system for treatment of glaucoma and methods and apparatus for its installation |
US5300020A (en) * | 1991-05-31 | 1994-04-05 | Medflex Corporation | Surgically implantable device for glaucoma relief |
US5147370A (en) | 1991-06-12 | 1992-09-15 | Mcnamara Thomas O | Nitinol stent for hollow body conduits |
US5326345A (en) * | 1991-08-14 | 1994-07-05 | Price Jr Francis W | Eye filtration prostheses |
US5171213A (en) * | 1991-08-14 | 1992-12-15 | Price Jr Francis W | Technique for fistulization of the eye and an eye filtration prosthesis useful therefor |
US5360399A (en) | 1992-01-10 | 1994-11-01 | Robert Stegmann | Method and apparatus for maintaining the normal intraocular pressure |
WO1993014702A1 (en) * | 1992-01-29 | 1993-08-05 | Stewart Gregory Smith | Method and apparatus for phaco-emulsification |
US5283063A (en) * | 1992-01-31 | 1994-02-01 | Eagle Vision | Punctum plug method and apparatus |
US5190552A (en) * | 1992-02-04 | 1993-03-02 | Kelman Charles D | Slotted tube injector for an intraocular lens |
US5217486A (en) * | 1992-02-18 | 1993-06-08 | Mitek Surgical Products, Inc. | Suture anchor and installation tool |
US5346464A (en) | 1992-03-10 | 1994-09-13 | Camras Carl B | Method and apparatus for reducing intraocular pressure |
US5221278A (en) * | 1992-03-12 | 1993-06-22 | Alza Corporation | Osmotically driven delivery device with expandable orifice for pulsatile delivery effect |
US5380290A (en) * | 1992-04-16 | 1995-01-10 | Pfizer Hospital Products Group, Inc. | Body access device |
US5322504A (en) * | 1992-05-07 | 1994-06-21 | United States Surgical Corporation | Method and apparatus for tissue excision and removal by fluid jet |
US5355871A (en) | 1992-09-11 | 1994-10-18 | Dexide, Inc. | Elastomeric controller for endoscopic surgical instruments |
IL106946A0 (en) | 1992-09-22 | 1993-12-28 | Target Therapeutics Inc | Detachable embolic coil assembly |
WO1994007436A1 (en) * | 1992-09-30 | 1994-04-14 | Vladimir Feingold | Intraocular lens insertion system |
US5370607A (en) | 1992-10-28 | 1994-12-06 | Annuit Coeptis, Inc. | Glaucoma implant device and method for implanting same |
ES2141746T3 (en) | 1992-11-06 | 2000-04-01 | Grieshaber & Co Ag | OPHTHALMOLOGICAL ASPIRATION AND IRRIGATION SYSTEM. |
US5338291A (en) * | 1993-02-03 | 1994-08-16 | Pudenz-Schulte Medical Research Corporation | Glaucoma shunt and method for draining aqueous humor |
USD356867S (en) * | 1993-03-10 | 1995-03-28 | Hood Laboratories | Device for controlling intraocular fluid pressure |
US5342370A (en) * | 1993-03-19 | 1994-08-30 | University Of Miami | Method and apparatus for implanting an artifical meshwork in glaucoma surgery |
US5433714A (en) * | 1993-04-06 | 1995-07-18 | Bloomberg; Leroy | Topical anesthesia method for eye surgery, and applicator therefor |
KR950702068A (en) * | 1993-04-06 | 1995-05-17 | 쓰지 가오루 | Package for SEMICONDUCTOR CHIP |
DE4313245C2 (en) | 1993-04-23 | 1997-03-27 | Geuder Hans Gmbh | Hollow needle for an ophthalmic surgical instrument |
CN2169402Y (en) * | 1993-10-28 | 1994-06-22 | 五河县人民医院 | Anti-glaucoma drain apparatus |
IL109499A (en) * | 1994-05-02 | 1998-01-04 | Univ Ramot | Implant device for draining excess intraocular fluid |
FR2721499B1 (en) * | 1994-06-22 | 1997-01-03 | Opsia | Trabeculectomy implant. |
US5520631A (en) * | 1994-07-22 | 1996-05-28 | Wound Healing Of Oklahoma | Method and apparatus for lowering the intraocular pressure of an eye |
US5704907A (en) * | 1994-07-22 | 1998-01-06 | Wound Healing Of Oklahoma | Method and apparatus for lowering the intraocular pressure of an eye |
US6102045A (en) | 1994-07-22 | 2000-08-15 | Premier Laser Systems, Inc. | Method and apparatus for lowering the intraocular pressure of an eye |
US5522845A (en) * | 1994-09-27 | 1996-06-04 | Mitek Surgical Products, Inc. | Bone anchor and bone anchor installation |
US5601094A (en) * | 1994-11-22 | 1997-02-11 | Reiss; George R. | Ophthalmic shunt |
US5660205A (en) * | 1994-12-15 | 1997-08-26 | Epstein; Alan B. | One-way valve |
US5433701A (en) * | 1994-12-21 | 1995-07-18 | Rubinstein; Mark H. | Apparatus for reducing ocular pressure |
US5558630A (en) | 1994-12-30 | 1996-09-24 | Fisher; Bret L. | Intrascleral implant and method for the regulation of intraocular pressure |
US5626558A (en) * | 1995-05-05 | 1997-05-06 | Suson; John | Adjustable flow rate glaucoma shunt and method of using same |
IL113723A (en) * | 1995-05-14 | 2002-11-10 | Optonol Ltd | Intraocular implant |
US5968058A (en) | 1996-03-27 | 1999-10-19 | Optonol Ltd. | Device for and method of implanting an intraocular implant |
CN1283324C (en) * | 1995-05-14 | 2006-11-08 | 奥普通诺尔有限公司 | Intraocular implant, delivery device, and method of implantation |
US5662600A (en) | 1995-09-29 | 1997-09-02 | Pudenz-Schulte Medical Research Corporation | Burr-hole flow control device |
US5741292A (en) * | 1995-10-26 | 1998-04-21 | Eagle Vision | Punctum dilating and plug inserting instrument with push-button plug release |
US5709698A (en) * | 1996-02-26 | 1998-01-20 | Linvatec Corporation | Irrigating/aspirating shaver blade assembly |
US5665101A (en) * | 1996-04-01 | 1997-09-09 | Linvatec Corporation | Endoscopic or open lipectomy instrument |
US5865831A (en) * | 1996-04-17 | 1999-02-02 | Premier Laser Systems, Inc. | Laser surgical procedures for treatment of glaucoma |
US5980480A (en) * | 1996-07-11 | 1999-11-09 | Cs Fluids, Inc. | Method and apparatus for treating adult-onset dementia of the alzheimer's type |
US5807240A (en) | 1996-09-24 | 1998-09-15 | Circon Corporation | Continuous flow endoscope with enlarged outflow channel |
US6007510A (en) | 1996-10-25 | 1999-12-28 | Anamed, Inc. | Implantable devices and methods for controlling the flow of fluids within the body |
FR2757068B1 (en) | 1996-12-13 | 1999-04-23 | Jussmann Alberto | SELF-FIXING DRAIN |
GB9700390D0 (en) * | 1997-01-10 | 1997-02-26 | Biocompatibles Ltd | Device for use in the eye |
US5713844A (en) * | 1997-01-10 | 1998-02-03 | Peyman; Gholam A. | Device and method for regulating intraocular pressure |
US5893837A (en) * | 1997-02-28 | 1999-04-13 | Staar Surgical Company, Inc. | Glaucoma drain implanting device and method |
US6050970A (en) * | 1997-05-08 | 2000-04-18 | Pharmacia & Upjohn Company | Method and apparatus for inserting a glaucoma implant in an anterior and posterior segment of the eye |
US6004302A (en) | 1997-08-28 | 1999-12-21 | Brierley; Lawrence A. | Cannula |
US6007578A (en) | 1997-10-08 | 1999-12-28 | Ras Holding Corp | Scleral prosthesis for treatment of presbyopia and other eye disorders |
US6203513B1 (en) * | 1997-11-20 | 2001-03-20 | Optonol Ltd. | Flow regulating implant, method of manufacture, and delivery device |
US6168575B1 (en) * | 1998-01-29 | 2001-01-02 | David Pyam Soltanpour | Method and apparatus for controlling intraocular pressure |
BR0010055A (en) | 1999-04-26 | 2002-04-09 | Gmp Vision Solutions Inc | Bypass device and use thereof |
US20050119601A9 (en) * | 1999-04-26 | 2005-06-02 | Lynch Mary G. | Shunt device and method for treating glaucoma |
US6558342B1 (en) * | 1999-06-02 | 2003-05-06 | Optonol Ltd. | Flow control device, introducer and method of implanting |
US6221078B1 (en) * | 1999-06-25 | 2001-04-24 | Stephen S. Bylsma | Surgical implantation apparatus |
US6203512B1 (en) * | 1999-06-28 | 2001-03-20 | The Procter & Gamble Company | Method for opening a packaging device and retrieving an interlabial absorbent article placed therein |
US7008396B1 (en) | 1999-09-03 | 2006-03-07 | Restorvision, Inc. | Ophthalmic device and method of manufacture and use |
JP3292953B2 (en) | 1999-10-15 | 2002-06-17 | エヌイーシーインフロンティア株式会社 | Redundant transmission line device and redundant transmission line system |
US6245077B1 (en) * | 2000-01-21 | 2001-06-12 | Exmoor Plastics Ltd. | Universal myringotomy tube/aural grommet inserter and methods |
US20020143284A1 (en) | 2001-04-03 | 2002-10-03 | Hosheng Tu | Drug-releasing trabecular implant for glaucoma treatment |
US6730056B1 (en) | 2000-09-21 | 2004-05-04 | Motorola, Inc. | Eye implant for treating glaucoma and method for manufacturing same |
US7431710B2 (en) | 2002-04-08 | 2008-10-07 | Glaukos Corporation | Ocular implants with anchors and methods thereof |
JP2003102765A (en) * | 2001-09-28 | 2003-04-08 | Takashi Okano | Ocular tension adjusting member and method of adjusting ocular tension |
US20040147870A1 (en) | 2002-04-08 | 2004-07-29 | Burns Thomas W. | Glaucoma treatment kit |
CN100591372C (en) * | 2002-07-19 | 2010-02-24 | 耶鲁大学 | Uveoscleral drainage device |
CA2529495C (en) * | 2003-06-16 | 2013-02-05 | Solx, Inc. | Shunt for the treatment of glaucoma |
US20060069340A1 (en) | 2003-06-16 | 2006-03-30 | Solx, Inc. | Shunt for the treatment of glaucoma |
US7862531B2 (en) * | 2004-06-25 | 2011-01-04 | Optonol Ltd. | Flow regulating implants |
ES2762239T3 (en) | 2006-01-17 | 2020-05-22 | Alcon Inc | Glaucoma treatment device |
US20080108933A1 (en) | 2006-06-30 | 2008-05-08 | Dao-Yi Yu | Methods, Systems and Apparatus for Relieving Pressure in an Organ |
-
2004
- 2004-06-25 US US10/875,571 patent/US7862531B2/en active Active
-
2005
- 2005-06-16 ES ES05762232T patent/ES2753384T3/en active Active
- 2005-06-16 KR KR1020067026803A patent/KR101280961B1/en active IP Right Grant
- 2005-06-16 SG SG200904133-6A patent/SG153828A1/en unknown
- 2005-06-16 AU AU2005267539A patent/AU2005267539B2/en not_active Ceased
- 2005-06-16 CA CA2571871A patent/CA2571871C/en not_active Expired - Fee Related
- 2005-06-16 CN CN200580020919A patent/CN100577127C/en not_active Expired - Fee Related
- 2005-06-16 EP EP05762232.6A patent/EP1765234B1/en active Active
- 2005-06-16 JP JP2007518120A patent/JP4723577B2/en active Active
- 2005-06-16 WO PCT/US2005/021123 patent/WO2006012009A2/en active Application Filing
- 2005-06-16 CN CN2009102228242A patent/CN101732125B/en not_active Expired - Fee Related
-
2006
- 2006-12-19 IL IL180170A patent/IL180170A0/en not_active IP Right Cessation
-
2007
- 2007-12-07 US US11/952,754 patent/US8034016B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
WO2006012009A2 (en) | 2006-02-02 |
US20050288617A1 (en) | 2005-12-29 |
CN101732125A (en) | 2010-06-16 |
AU2005267539A1 (en) | 2006-02-02 |
SG153828A1 (en) | 2009-07-29 |
JP2008504063A (en) | 2008-02-14 |
KR20070031943A (en) | 2007-03-20 |
US20080077071A1 (en) | 2008-03-27 |
WO2006012009A3 (en) | 2006-03-09 |
ES2753384T3 (en) | 2020-04-08 |
CN100577127C (en) | 2010-01-06 |
JP4723577B2 (en) | 2011-07-13 |
CA2571871A1 (en) | 2006-02-02 |
KR101280961B1 (en) | 2013-07-02 |
US7862531B2 (en) | 2011-01-04 |
EP1765234B1 (en) | 2019-10-16 |
IL180170A0 (en) | 2007-06-03 |
US8034016B2 (en) | 2011-10-11 |
CN101076305A (en) | 2007-11-21 |
AU2005267539B2 (en) | 2011-12-08 |
EP1765234A2 (en) | 2007-03-28 |
CN101732125B (en) | 2012-07-04 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CA2571871C (en) | Flow regulating implants | |
KR100495373B1 (en) | Flow regulating implant, method of manufacturing, and delivery device | |
JP6074011B2 (en) | Fluid discharge and supply system | |
DE69633074D1 (en) | INTRAOCULAR IMPLANT, INSERTION DEVICE AND IMPLANTATION PROCEDURE | |
KR100355472B1 (en) | Intraocular implant, delivery device, and method of implantation | |
JP4195203B2 (en) | Implant and delivery device and method for manufacturing fluid control device | |
US20130131577A1 (en) | Uveoscleral drainage device | |
US20230285191A1 (en) | Intraocular shunt implantation methods and devices | |
US10952897B1 (en) | Eye implant devices and method and device for implanting such devices for treatment of glaucoma | |
EP4041148A1 (en) | Glaucoma shunts and related methods of use | |
AU2011253724B2 (en) | Flow regulating implants | |
RU2002108965A (en) | Method of microdraining in the treatment of glaucoma (options) |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |
Effective date: 20220301 |
|
MKLA | Lapsed |
Effective date: 20200831 |