CA2462392A1 - Tissue collection device and methods - Google Patents
Tissue collection device and methods Download PDFInfo
- Publication number
- CA2462392A1 CA2462392A1 CA002462392A CA2462392A CA2462392A1 CA 2462392 A1 CA2462392 A1 CA 2462392A1 CA 002462392 A CA002462392 A CA 002462392A CA 2462392 A CA2462392 A CA 2462392A CA 2462392 A1 CA2462392 A1 CA 2462392A1
- Authority
- CA
- Canada
- Prior art keywords
- chamber
- fluid
- collection device
- biological tissue
- tissue collection
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
- A61B10/0096—Casings for storing test samples
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/46—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor
- A61F2/4644—Preparation of bone graft, bone plugs or bone dowels, e.g. grinding or milling bone material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
- A61F2002/2835—Bone graft implants for filling a bony defect or an endoprosthesis cavity, e.g. by synthetic material or biological material
Abstract
A biological tissue collection device is provided having a housing with a fluid-retaining inner chamber adapted to retain a bioimplantable, fluid permeable tissue scaffold. The scaffold is preferably retained in the housing in such a way that the scaffold separates the fluid-retaining inner chamber into a first chamber and a second chamber. The collection device further includes a driver mechanism coupled to the housing and effective to create a force within the housing to displace fluid disposed within the second chamber to the first chamber. As the fluid is displaced, any biological tissue deposited on the tissue scaffold is dispersed within the fluid. Removal of the force enables the fluid to return to the second chamber and thereby deposit the tissue onto the tissue scaffold. In an exemplary embodiment, the tissue is deposited evenly onto the tissue scaffold.
Claims (42)
1. A biological tissue collection device, comprising:
a housing having a fluid-retaining inner chamber adapted to retain a bioimplantable, fluid permeable tissue scaffold in such a way that the scaffold separates the fluid-retaining inner chamber into a first chamber and a second chamber;
and a driver mechanism coupled to the housing and effective to create a force within the housing to displace fluid disposed within the second chamber to the first chamber and thereby disperse any biological tissue deposited on the tissue scaffold within the fluid, wherein removal of the force enables the fluid to return to the second chamber and thereby deposit the biological tissue onto the tissue scaffold.
a housing having a fluid-retaining inner chamber adapted to retain a bioimplantable, fluid permeable tissue scaffold in such a way that the scaffold separates the fluid-retaining inner chamber into a first chamber and a second chamber;
and a driver mechanism coupled to the housing and effective to create a force within the housing to displace fluid disposed within the second chamber to the first chamber and thereby disperse any biological tissue deposited on the tissue scaffold within the fluid, wherein removal of the force enables the fluid to return to the second chamber and thereby deposit the biological tissue onto the tissue scaffold.
2. The biological tissue collection device of claim 1, further comprising a bioimplantable, fluid permeable tissue scaffold disposed within the fluid-retaining inner chamber of the housing.
3. The biological tissue collection device of claim 2, further comprising a jet plate disposed within the second chamber and movable between an original position, in which the jet plate is positioned a distance apart from the tissue scaffold, and a second position, in which the driver mechanism applies a force that causes the jet plate to contact the tissue scaffold.
4. The biological tissue collection device of claim 3, wherein the jet plate, when disposed in the second position, is effective to apply pressure to a surface of the tissue scaffold to force any air bubbles formed on the tissue scaffold to flow into the first chamber.
5. The biological tissue collection device of claim 3, wherein the jet plate comprises a body having at least one channel extending therethrough for allowing fluid to flow through the jet plate.
6. The biological tissue collection device of claim 5, wherein the jet plate includes upper and lower surfaces, and wherein the at least one channel is oriented at an angle and extends between the upper and lower surfaces.
7. The biological tissue collection device of claim 6, wherein the at least one channel extends from a perimeter of the lower surface of the jet plate to a center of the upper surface of the jet plate.
8. The biological tissue collection device of claim 2, wherein the first chamber is disposed upstream of the tissue scaffold, and the second chamber is disposed downstream of the tissue scaffold.
9. The biological tissue collection device of claim 1, wherein the first chamber includes at least one entry port for delivering fluid into the first chamber.
10. The biological tissue collection device of claim 9, wherein the entry port includes a flow control valve effective to control the flow of fluid therethrough.
11. The biological tissue collection device of claim 9, wherein the driver mechanism comprises a plunger coupled to the first chamber, and wherein the entry port is formed through the plunger.
12. The biological tissue collection device of claim 1, wherein the driver mechanism is coupled to the first chamber and is effective to create a vacuum force to pull fluid from the second chamber into the first chamber.
13. The biological tissue collection device of claim 12, wherein the driver mechanism is selected from the group consisting of at least one plunger, a charged gas cylinder, and a vacuum pump.
14. The biological tissue collection device of claim 1, wherein the driver mechanism is coupled to the second chamber and is effective to create a force to push fluid from the second chamber into the first chamber.
15. The biological tissue collection device of claim 14, wherein the driver mechanism is selected from the group consisting of at least one plunger, a charged gas cylinder, and a vacuum pump.
16. The biological tissue collection device of claim 12, wherein the driver mechanism is formed integrally with the first chamber such that the first chamber is movable between a first position and a second position to create a vacuum force to draw fluid from the second chamber into the first chamber.
17. The biological tissue collection device of claim 1, wherein the second chamber includes an overflow mechanism effective to allow any excess fluid disposed within the second chamber to be released.
18. The biological tissue collection device of claim 17, wherein the overflow mechanism is selected from the group consisting of a channel, a port, and a valve.
19. The biological tissue collection device of claim 1, further comprising a retaining member effective to retain a tissue scaffold within the chamber.
20. The biological tissue collection device of claim 19, wherein the retaining member comprises a wire mesh disposed within the housing between the first and second chambers, the wire mesh being adapted to seat a tissue scaffold.
21. The biological tissue collection device of claim 19, wherein the retaining member comprises a clamping ring effective to clamp an outer perimeter of a tissue scaffold.
22. The biological tissue collection device of claim 19, wherein the retaining member is removably disposed within the inner chamber of the housing.
23. The biological tissue collection device of claim 22, wherein the housing includes a transverse slot formed therein for removably receiving the retaining member.
24. The biological tissue collection device of claim 22, wherein the housing comprises a first portion defining the first inner chamber, and a second portion defining the second inner chamber. the first and second portions being adapted to removably mate to one another and to receive a tissue scaffold therebetween.
25. The biological tissue collection device of claim 24, wherein the first and second portions define the retaining member.
26. The biological tissue collection device of claim 1, wherein the housing includes a proximal end, a distal end, and a sidewall extending therebetween and defining the fluid-retaining inner chamber, and wherein the first chamber is formed within a proximal portion of the housing, and the second chamber is formed within a distal portion of the housing.
27. The biological tissue collection device of claim 26, wherein the driver mechanism comprises a plunger disposed within the first chamber and movable between a first position, in which the plunger is positioned at a distal end of the first chamber, and a second position, in which the plunger is positioned adjacent the proximal end of the housing.
28. The biological tissue collection device of claim 27, wherein movement of the plunger from the first position to the second position is effective to create a vacuum within the fluid-retaining inner chamber of the housing to draw fluid disposed within the second chamber into the first chamber.
29. The biological tissue collection device of claim 28, further comprising a driver release mechanism coupled to the first chamber and effective to release the vacuum within the fluid-retaining inner chamber of the housing.
30. The biological tissue collection device of claim 29, wherein the driver release mechanism comprises an air flow entry port formed in the sidewall of the housing adjacent the proximal end of the housing and effective to allow air to enter the fluid-retaining inner chamber when the plunger is positioned proximal to the air flow entry port.
31. A biological tissue collection device, comprising:
a housing having a proximal chamber, a distal chamber, and a tissue scaffold retaining member disposed therebetween;
a driver mechanism coupled to the proximal chamber and effective to create a fluid driving force within the first and second chambers; and a driver release mechanism formed in one of the first and second chambers and that is effective to release the force applied by the driver mechanism.
a housing having a proximal chamber, a distal chamber, and a tissue scaffold retaining member disposed therebetween;
a driver mechanism coupled to the proximal chamber and effective to create a fluid driving force within the first and second chambers; and a driver release mechanism formed in one of the first and second chambers and that is effective to release the force applied by the driver mechanism.
32. The biological tissue collection device of claim 31, further comprising a jet plate disposed within the distal chamber that, when the driver mechanism is activated, is effective to control fluid flow.
33. The biological tissue collection device of claim 31, wherein the proximal chamber includes at least one entry port for delivering fluid into the proximal chamber.
34. The biological tissue collection device of claim 31, wherein the distal chamber includes an overflow mechanism effective to allow any excess fluid disposed within the distal chamber to be released.
35. The biological tissue collection device of claim 31, wherein the retaining member is removably disposed within the housing.
36. A method of preparing a tissue scaffold, comprising the steps of providing a biological tissue collection device having a housing having a fluid-retaining inner chamber;
a bioimplantable, fluid permeable tissue scaffold disposed within the fluid-retaining inner chamber of the housing such that the tissue scaffold separates the fluid-retaining inner chamber into a first chamber and a second chamber, and a driver mechanism coupled to the housing and effective to create a force within the housing;
delivering a biological tissue-containing fluid into the first chamber, wherein the biological tissue is deposited onto the tissue scaffold and the fluid flows through the tissue scaffold and into the second chamber;
activating the driver mechanism to cause fluid to be displaced from the second chamber and into the first chamber, whereby any biological tissue deposited on the tissue scaffold is dispersed within the fluid;
releasing the driver mechanism to enable the fluid to return to the second chamber and thereby deposit the biological tissue onto the tissue scaffold.
a bioimplantable, fluid permeable tissue scaffold disposed within the fluid-retaining inner chamber of the housing such that the tissue scaffold separates the fluid-retaining inner chamber into a first chamber and a second chamber, and a driver mechanism coupled to the housing and effective to create a force within the housing;
delivering a biological tissue-containing fluid into the first chamber, wherein the biological tissue is deposited onto the tissue scaffold and the fluid flows through the tissue scaffold and into the second chamber;
activating the driver mechanism to cause fluid to be displaced from the second chamber and into the first chamber, whereby any biological tissue deposited on the tissue scaffold is dispersed within the fluid;
releasing the driver mechanism to enable the fluid to return to the second chamber and thereby deposit the biological tissue onto the tissue scaffold.
37. The method of claim 36, wherein the biological tissue is uniformly deposited onto the scaffold.
38. The method of claim 36, wherein the driver mechanism is coupled to the first chamber and is effective to create a vacuum force to draw fluid from the second chamber into the first chamber.
39. The method of claim 36, wherein the driver mechanism is coupled to the second chamber and is effective to create a force to push fluid from the second chamber into the first chamber.
40. The method of claim 36, wherein the biological tissue collection device further comprises a jet plate disposed within the second chamber and movable between an original position, in which the jet plate is positioned a distance apart from the tissue scaffold, and a second position, in which the driver mechanism applies a force that causes the jet plate to contact the tissue scaffold.
41. The method of claim 40, wherein the jet plate is effective to apply pressure to a surface of the tissue scaffold in the second position to compress any air bubbles formed on the tissue scaffold.
42. The method of claim 40, wherein the jet plate comprises a body having at least one channel extending therethrough for allowing fluid to flow through the jet plate.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/402,266 US7794408B2 (en) | 2003-03-28 | 2003-03-28 | Tissue collection device and methods |
US10/402,266 | 2003-03-28 |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2462392A1 true CA2462392A1 (en) | 2004-09-28 |
CA2462392C CA2462392C (en) | 2011-10-18 |
Family
ID=32825043
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2462392A Expired - Fee Related CA2462392C (en) | 2003-03-28 | 2004-03-29 | Tissue collection device and methods |
Country Status (6)
Country | Link |
---|---|
US (2) | US7794408B2 (en) |
EP (1) | EP1462059B1 (en) |
JP (1) | JP4698964B2 (en) |
AU (1) | AU2004201201B2 (en) |
CA (1) | CA2462392C (en) |
DE (1) | DE602004025872D1 (en) |
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2003
- 2003-03-28 US US10/402,266 patent/US7794408B2/en active Active
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2004
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2010
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AU2004201201A1 (en) | 2004-10-14 |
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EP1462059A3 (en) | 2005-04-06 |
CA2462392C (en) | 2011-10-18 |
US20100280406A1 (en) | 2010-11-04 |
US8562542B2 (en) | 2013-10-22 |
JP2004298630A (en) | 2004-10-28 |
EP1462059A2 (en) | 2004-09-29 |
DE602004025872D1 (en) | 2010-04-22 |
JP4698964B2 (en) | 2011-06-08 |
AU2004201201B2 (en) | 2006-04-13 |
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