CA2355051A1 - Nonpenetrating electroporation device - Google Patents

Nonpenetrating electroporation device Download PDF

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Publication number
CA2355051A1
CA2355051A1 CA002355051A CA2355051A CA2355051A1 CA 2355051 A1 CA2355051 A1 CA 2355051A1 CA 002355051 A CA002355051 A CA 002355051A CA 2355051 A CA2355051 A CA 2355051A CA 2355051 A1 CA2355051 A1 CA 2355051A1
Authority
CA
Canada
Prior art keywords
target tissue
electrodes
establish
electromagnetic field
support
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002355051A
Other languages
French (fr)
Other versions
CA2355051C (en
Inventor
Richard Gilbert
Mark J. Jaroszeski
Richard Heller
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of South Florida
Original Assignee
University Of South Florida
Richard Gilbert
Mark J. Jaroszeski
Richard Heller
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University Of South Florida, Richard Gilbert, Mark J. Jaroszeski, Richard Heller filed Critical University Of South Florida
Publication of CA2355051A1 publication Critical patent/CA2355051A1/en
Application granted granted Critical
Publication of CA2355051C publication Critical patent/CA2355051C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/327—Applying electric currents by contact electrodes alternating or intermittent currents for enhancing the absorption properties of tissue, e.g. by electroporation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0412—Specially adapted for transcutaneous electroporation, e.g. including drug reservoirs
    • A61N1/0416—Anode and cathode
    • A61N1/0424—Shape of the electrode
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/325—Applying electric currents by contact electrodes alternating or intermittent currents for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0472—Structure-related aspects
    • A61N1/0476—Array electrodes (including any electrode arrangement with more than one electrode for at least one of the polarities)

Abstract

The manipulator (10) includes a support and at least one member affixed to an extending away from the support. The member has at least two differentially activatable electrodes (126). The electrodes are configured to establish a first electromagnetic field in vivo between selected electrodes sufficient to manipulate a molecule relative to a target tissue and to establish a second, typically higher, electromagnetic field sufficient to cause transient permeability of a cell membrane within the target tissue (T). One method of using the device is for enhancing the delivery of a molecule into a tissue site. In a related embodiment the device may be used to cause the electromigration of at least two components of a multicomponent reactive system into apposition to permit a reaction to occur at a desired target tissue site. The target tissue may comprise a tumor, organ, or wound site.
CA002355051A 1998-12-17 1999-12-15 Nonpenetrating electroporation device Expired - Fee Related CA2355051C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/213,218 US6314316B1 (en) 1998-12-17 1998-12-17 Nonpenetrating electroporation device and method
US09/213,218 1998-12-17
PCT/US1999/029722 WO2000035532A1 (en) 1998-12-17 1999-12-15 Nonpenetrating electroporation device

Publications (2)

Publication Number Publication Date
CA2355051A1 true CA2355051A1 (en) 2000-06-22
CA2355051C CA2355051C (en) 2003-12-09

Family

ID=22794209

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002355051A Expired - Fee Related CA2355051C (en) 1998-12-17 1999-12-15 Nonpenetrating electroporation device

Country Status (8)

Country Link
US (1) US6314316B1 (en)
EP (2) EP1140282B1 (en)
JP (1) JP2002532166A (en)
AT (1) ATE289215T1 (en)
AU (1) AU768451B2 (en)
CA (1) CA2355051C (en)
DE (2) DE69923787T2 (en)
WO (1) WO2000035532A1 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6714816B1 (en) * 2000-02-22 2004-03-30 University Of South Florida Electroporation and electrophoresis system and method for achieving molecular penetration into cells in vivo
AU2002245675A1 (en) * 2001-03-13 2002-09-24 University Of South Florida Electromanipulation device and method
US8209006B2 (en) * 2002-03-07 2012-06-26 Vgx Pharmaceuticals, Inc. Constant current electroporation device and methods of use
US7245963B2 (en) * 2002-03-07 2007-07-17 Advisys, Inc. Electrode assembly for constant-current electroporation and use
US20050282283A1 (en) * 2004-04-19 2005-12-22 Laura Vozza-Brown Electroporation apparatus and methods
EP2266656B1 (en) * 2005-04-18 2020-10-28 INSERM (Institut National de la Santé et de la Recherche Médicale) Devices for delivering a biologically active agent to the ocular sphere of a subject
WO2007117651A2 (en) 2006-04-07 2007-10-18 University Of South Florida Passive electric field focus system for in vivo and in vitro applications
DE102006022554B4 (en) * 2006-05-15 2014-12-04 Roche Diagnostics Gmbh A method and apparatus for stimulating tissue for the subcutaneous administration of drugs
JP2011509743A (en) * 2008-01-17 2011-03-31 ジェネトロニクス，インコーポレイティド Variable current density single needle electroporation system and method
WO2010106544A1 (en) * 2009-03-16 2010-09-23 Rajah Vijay Kumar A method and apparatus for - focused resonance nanopermeabilization (forn)
JP5822247B1 (en) * 2014-07-28 2015-11-24 ネッパジーン株式会社 ELECTRIC PULSE GENERATOR FOR ELECTROPOLATOR AND ELECTROPOLATOR DEVICE PROVIDED WITH THE ELECTRIC PULSE GENERATOR
CN106459858B (en) * 2014-07-28 2018-01-30 内帕基因株式会社 Electroporation electric pulse generator and the electroporation device for possessing the electric pulse generator

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1099062A (en) * 1913-12-10 1914-06-02 Peter P Laposkey Electric scalp appliance.
US4970154A (en) * 1987-10-09 1990-11-13 Baylor College Of Medicine Method for inserting foreign genes into cells using pulsed radiofrequency
US5318514A (en) 1992-08-17 1994-06-07 Btx, Inc. Applicator for the electroporation of drugs and genes into surface cells
US6009345A (en) * 1992-08-17 1999-12-28 Genetronics, Inc. Method and apparatus for a combination of electroporation and iontophoresis for the delivery of drugs and genes
FR2703253B1 (en) 1993-03-30 1995-06-23 Centre Nat Rech Scient APPLICATOR OF ELECTRIC PULSES FOR TREATING BIOLOGICAL TISSUES.
US5439440A (en) 1993-04-01 1995-08-08 Genetronics, Inc. Electroporation system with voltage control feedback for clinical applications
US5993434A (en) 1993-04-01 1999-11-30 Genetronics, Inc. Method of treatment using electroporation mediated delivery of drugs and genes
US5707349A (en) * 1994-05-09 1998-01-13 Somnus Medical Technologies, Inc. Method for treatment of air way obstructions
US5983130A (en) * 1995-06-07 1999-11-09 Alza Corporation Electrotransport agent delivery method and apparatus
JPH09266954A (en) * 1996-04-03 1997-10-14 Meiwa Shoji Kk Therapy machine with electrode
US5869326A (en) * 1996-09-09 1999-02-09 Genetronics, Inc. Electroporation employing user-configured pulsing scheme
US5873849A (en) * 1997-04-24 1999-02-23 Ichor Medical Systems, Inc. Electrodes and electrode arrays for generating electroporation inducing electrical fields

Also Published As

Publication number Publication date
DE69923787D1 (en) 2005-03-24
DE69923787T2 (en) 2006-01-05
EP1504787A1 (en) 2005-02-09
JP2002532166A (en) 2002-10-02
CA2355051C (en) 2003-12-09
EP1140282A1 (en) 2001-10-10
DE69938013T2 (en) 2009-01-15
AU768451B2 (en) 2003-12-11
EP1504787B1 (en) 2008-01-16
AU2053600A (en) 2000-07-03
ATE289215T1 (en) 2005-03-15
WO2000035532A1 (en) 2000-06-22
DE69938013D1 (en) 2008-03-06
EP1140282B1 (en) 2005-02-16
US6314316B1 (en) 2001-11-06

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EEER Examination request
MKLA Lapsed

Effective date: 20161215